Кафедра внутрішніх та професійних хвороб
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Item Clinical COPD Questionnaire results depending on the degree of the inflammatory response in patients with COPD combined with hypertension(2021-11-25) Melenevych, AnastasiiaLittle is known about the relationship between Clinical COPD Questionnaire (CCQ) score and degree of the inflammatory response in patients with COPD combined with hypertension (HT). We analyzed CCQ scores depending on the 6-min walk test (6MWT) and pulse oximetry data. An inverse correlation was found between the distance walked in 6MWT and the total CCQ score (r=-0,74; p<0,05); the functional state domain score (r=-0,75; p<0,05); the symptom domain score (r=-0,48; p<0,05) and the mental state domain score (r=-0,46; p<0,05). A direct correlation was found between desaturation and the total CCQ score (r=0,66; p<0,05); the functional state domain score (r=0,77; p<0,05) and the mental state domain score (r=0,41; p<0,05).We investigated serum IL-18 and IL-10 levels in 69 COPD (GOLD 2, group B) patients in remission in combination with HT stage II (57 males and 12 females; mean age 55,80±5,51 years). Patients were divided into three groups – tertiles, depending on the level of IL-18/IL-10 ratio. It was found that the growth of IL-18/IL-10 ratio significantly (p<0,001) associated with increasing the functional state domain score. The mean score of the functional state CCQ domain in patients of the 1st tertile was 2,38, 2nd - 2,50 and 3rd - 3,21.Thus, the functional state CCQ domain score significantly represented the imbalance between IL-18 and IL-10 in COPD with HT patients.Item Complement C3 and C-reactive protein in patients with moderate chronic obstructive pulmonary disease in remission in combination with hypertension(2024-07) Melenevych, AnastasiiaCardiovascular diseases remain the most common comorbid pathology among patients with chronic obstructive pulmonary disease (COPD). The prevalence of hypertension (HT) in COPD patients reaches 51,2%. Systemic inflammation, endothelial dysfunction, oxidative stress are common links in the pathogenesis of combined cardiopulmonary pathology that contribute to progression. Complement 3 (C3) is a key component of the complement system that plays an important role in the detection and elimination of pathogens. There is evidence for the protective role of C3 against oxidative stress, bronchial and myocardial apoptosis. The role of complement activation in relation to C-reactive protein (CRP) level in the pathogenesis of moderate COPD combined with HT has not been fully understood. We found that in moderate COPD patients combined with HT, C3 and CRP serum levels were significantly higher. C3 serum level predicted desaturation and emphysema in both groups, whereas CRP - in isolated COPD group only.Item Desaturation and IL-18/IL-10 ratio as prognostic predictors for adverse right ventricular remodeling(2021-09) Melenevych, Anastasiia; Melenevych, OlgaAdverse right ventricular (RV) remodeling leads to heart failure that represents an important determinant of outcome in patients with hypertension (HT) combined with chronic obstructive pulmonary disease (COPD). Chronic hypoxia and systemic inflammation contribute to tissue destruction and disruption normal repair and defense mechanisms, resulting in pulmonary vascular remodeling and pulmonary hypertension. We found that desaturation is associated with inflammatory activation and contributes to right heart chambers overload. The cut off level of IL-18/IL-10 ratio 26.64 is an independent prognostic predictor for RV pressure overload in patients with HT stage II in combination with moderate COPD.Item Diagnostic and prognostic role of markers of immune inflammation in chronic obstructive pulmonary disease in combination with hypertension(2016) Melenevych, AnastasiiaCurrently 210 million people have chronic obstructive pulmonary disease and it is predicted to become the third leading cause of death worldwide by 2030. In 2008, worldwide, approximately 40% of adults aged 25 and above had been diagnosed with hypertension. We have analyzed the most significant factors associated with increased cardiovascular risk in patients with COPD.Item Exercise-induced desaturation as an independent predictor of the occupational chronic obstructive pulmonary disease course in combination with hypertension(2023-05) Melenevych, Anastasiia; Kapustnik, Valeriy; Shelest, BorysWe found a significantly greater drop in the level of oxygen saturation (SpO2) during the 6-minute walk test (6MWT) in comorbid pathology compared to isolated COPD 62 (4,14±1,44 % vs. 3,39±1,31 %, p<0,05). Exercise-induced desaturation (EID), a 4 % drop in SpO2 during the 6MWT from the initial value, occurred significantly more often in comorbid pathology – in 56,5 % of patients, compared to 48,4 % in the isolated COPD group. In comorbid patients with EID, a significant (p<0,001) increase in pro-inflammatory interleukin (IL)-18 (3296,24 (2356,03; 3978,92) pg/ml vs. 2256,30 (1980,88; 2738,86) was found) pg/ml) and a decrease in anti-inflammatory IL-10 (61,12 (48,34; 79,63) pg/ml vs. 106,35 (89,45; 126,97) pg/ml) compared to patients without EID, which indicates a greater imbalance in the formation of the inflammatory response. EID in patients of the main group was associated with an increase in the right ventricular (RV) wall thickness (5,58±0,57 mm vs. 5,22±0,61, p<0,05), growth of the right atrium diameter (39,79±2,27 mm vs. 35,83±5,02 mm, p<0.05) and a decrease in the RV diameter (27,10±2,22 mm vs. 28,37±2,40 mm, p<0.05) in comparison with comorbid patients without EID. Patients with chronic obstructive pulmonary disease (COPD) and , hypertension (HT) with EID have more pronounced signs of RV pressure overload. Receiver-operating characteristic (ROC) analysis revealed the prognostic significance (p<0,001) of IL-18 level more than 3063,7 pg/ml (with a sensitivity of 61,5 % and a specificity of 90 %, area under the ROC curve (AUC) – 0,736) and the IL-18/IL-10 ratio value more than 39,9 (with a sensitivity of 76,9 % and a specificity of 83,3 %, AUC – 0,791) for EID in COPD patients combined with HT.Item Gender differences in exercise capacity and left ventricular geometry among patients with comorbid pathology – hypertension with chronic obstructive pulmonary disease(2023-09) Melenevych, AnastasiiaHypertension (HT) and chronic obstructive pulmonary disease (COPD) are one of the most common comorbid pathologies associated with the risk of cardiovascular events. As long as the ejection fraction (EF) remains preserved, it is quite challenging to establish signs of heart failure. Dyspnea and exercise intolerance in COPD can mask reduced heart function, especially in hypertensive patients. Our aim was to assess gender differences in exercise capacity using 6-min walk test (6MWT) and left ventricular (LV) geometry among patients with HT and COPD. We found that dyspnea level before and after the 6MWT, drop in SpO2 during the 6MWT as well as the distance walked in the 6MWT showed no significant (p > 0,05) gender differences. LV systolic function was preserved in all patients (EF > 55 %). LV diastolic function echocardiographic parameters didn’t show significant differences between men and women. At the same time, we found that all women had unfavorable types of LV geometry (concentric and eccentric hypertrophy), concentric hypertrophy was predominated. All four types of LV geometry were found among men. Thus, despite the lack of differences in clinical and functional data by gender, the predominance of LV concentric hypertrophy in women was reliably established among the patients with HT and COPD.Item IL-18 and IL-10 in patients with occupational COPD, depending on the presence or absence of hypertension(2018) Melenevych, AnastasiiaElevated levels of IL-18 and IL-10 in the serum of patients with occupational COPD in combination with HT indicate an increase in systemic low-grade inflammation in patients with comorbid pathology - COPD and HT.Item Impact of right ventricular diastolic function on exercise tolerance in patients with chronic obstructive pulmonary disease and hypertension(2023-07) Melenevych, AnastasiiaWe evaluated the impact of right ventricular (RV) diastolic function on exercise tolerance in patients with chronic obstructive pulmonary disease (COPD) and hypertension (HT). Analysis of RV diastolic function showed reduced early RV filling (p<0.05) and the ratio between early RV filling (E-wave) and late RV filling (A-wave) (E/A ratio) (p=0.007), elevated E-wave deceleration time (p<0.05) and isovolumic relaxation time (p<0.05) in the COPD with HT compared to the isolated COPD patients. It indicates a more pronounced relaxation disturbances and increased RV stiffness in patients with COPD combined with HT. We found RV diastolic dysfunction in the majority of comorbid patients – 78,2%, impaired relaxation (Grade I) was the predominant grade (50.7%), pseudo-normalized (Grade II) diastolic function was determined in 27,5%. In the isolated COPD group, normal diastolic function predominated (58.1%), pseudo-normalized - was less common (12,9%). Restricted (Grade III) RV diastolic dysfunction was not registered in our patients. Among patients with COPD and hypertension significant differences (p<0.05) were found in exercise tolerance parameters between patients with normal RV diastolic function (n=15) and RV diastolic dysfunction (n=54): the 6-min walk distance - 393.2±14.61 m vs. 380.69±13.85 m; exercise-induced dyspnea (Borg scale) - 3.4±0.63 vs. 3.98±1.0; exercise-induced oxygen desaturation - 3.4±1.3 vs. 4.35±1.42%. In the isolated COPD group reliable distinctions (p<0.05) were found in exercise tolerance parameters between patients with normal RV diastolic function (n=18) and RV diastolic dysfunction (n=13): the 6-min walk distance - 402.06±17.75 m vs. 386.85±17.6 m; exercise-induced dyspnea (Borg scale) -3.22±0.65 vs. 3.92±0.95. There was no significant difference in exercise-induced oxygen desaturation between COPD patients with normal RV diastolic function and RV diastolic dysfunction. Thus, RV diastolic dysfunction contributes to exercise intolerance and exercise-induced oxygen desaturation in patients with COPD and HT.Item Item Interleukin-18/interleukin-10 ratio in predicting the further course of chronic obstructive pulmonary disease combined with hypertension(2019) Kapustnik, Valeriy; Kostyuk, Inna; Melenevych, AnastasiiaThe article presents the results of analysis of main prognostically signifcant criteria depending on the values of interleukin-18/interleukin-10 (IL-18/IL-10) ratio in patients with chronic obstructive pulmonary disease (COPD) combined with hypertension (HT). Growth of IL-18/IL-10 ratio was associated with emphysematous changes in chest X-ray, increase in the degree of dyspnea, decreased exercise tolerance, increased levels of desaturation, lower body mass index, waist and mid-arm circumferences. The results of echocardiography revealed that all patients with comorbid pathology had signs of myocardial overload.Item Interleukin-18/interleukin-10 ratio in predicting the further course of chronic obstructive pulmonary disease combined with hypertension(General medicine, 2019) Kapustnik, Valeriy; Kostyuk, Inna; Melenevych, AnastasiiaThe article presents the results of analysis of main prognostically significant criteria depending on the values of interleukin-18/interleukin-10 (IL-18/IL-10) ratio in patients with chronic obstructive pulmonary disease (COPD) combined with hypertension (HT). Growth of IL-18/IL-10 ratio was associated with emphysematous changes in chest X-ray, increase in the degree of dyspnea, decreased exercise tolerance, increased levels of desaturation, lower body mass index, waist and mid-arm circumferences. The results of echocardiography revealed that all patients with comorbid pathology had signs of myocardial overload. Patients of the first tertile (IL-18/IL-10 < 23) had more pronounced signs of an overload of the left heart. Instead, patients of the third tertile (IL-18/IL-10 ≥ 59) had more pronounced signs of an overload of the right heart by pressure. Prognostically unfavorable types of left ventricular geometry (concentric hypertrophy and eccentric hypertrophy) were more common in patients of the first tertile.Item Particularities of inflammatory markers changes in patients with chronic kidney disease complicated with arterial hypertension(KhNMU, 2013-05) Shelest, Borys; Shatilova, Julia; Kycherenko, DanilThe aim was to study the dynamics of inflammatory markers CRP, IL-1β, IL-4, TNF-α − under the influence of hypertension in patients with CKD. Methods: Included in the study 56 patients with CKD, the first group (n=27) was represented by patients with high blood pressure (BP) systolic blood pressure> 140 mm Hg., BP diastolic <90 mm Hg., the second group - patients with CKD and normal values of BP. The control group consisted of 20 healthy individuals. Cytokines and CRP levels were determined by ELISA. Results and discussion. Revealed a significant increase of inflammatory markers CRP, IL-1β, TNF-α in patients with CKD compared with the control group, whereas anti-inflammatory IL-4 was reduced. For chronic kidney disease with hypertension were characterized by the increasing in CRP, TNF-α and IL-1β and decreasing of anti-inflammatory interleukin-4. It is important to note, that in comparison with the group of patients with normal pressure, patients with hypertension had significantly elevated levels of TNF-α (65,25 ± 4,57, p<0,05). Conclusions. Joining hypertension to CKD leads to greater activation of the inflammatory process in these patients. The level of anti-inflammatory IL-4 was almost equally low in both groups, compared with controls, regardless of the presence of hypertension.Item Right ventricular remodeling as an unfavorable feature in patients with chronic obstructive pulmonary disease combined with hypertension(2021-11) Melenevych, Anastasiia; Eshie, VictorWe investigated 69 patients with hypertension (HT) stage II in combination with chronic obstructive pulmonary disease (COPD) (GOLD 2, group B) in remission (57 males and 12 females ; mean age 55,80±5,51 years) who underwent 6-min walk test (6MWT), pulse oximetry, spirometry, chest X-ray, electrocardiography and echocardiography. IL-18 and IL-10 in the serum were determined by ELISA using a test system «Bender MedSystems, GmbH» (Austria). Worsening breathlessness, decreased tolerance to physical activity, reduction in oxygen saturation (SpO2) after 6MWT was associated with RV structural and functional impairment. Significant (p<0,05) differences in right heart chambers, indicating an increase in their overload, was found depending on the presence or absence of desaturation, i.e. decrease SpO2 during 6MWT more than 4% from baseline or below 90%: right atrial size - 39,79±2,27 mm vs. 35,83±5,02 mm; RV diameter - 27,10±2,22 mm vs. 28,37±2,40 mm; RV wall thickness - 5,58±0,57 mm vs. 5,22±0,61 mm; pulmonary artery to aorta ratio - 0,75±0,07 vs. 0,71±0,08. RV pressure overload (RV wall thickness > 5 mm and RV diameter < 30 mm) was associated with an imbalance of inflammatory response with increasing proinflammatory IL-18 and decreasing antiinflammatory IL-10. RV remodeling in response to pressure overload is often accompanied by maladaptive RV structural and functional impairment. Thus, RV remodeling with signs of overload by pressure was associated with increasing breathlessness, decreasing tolerance to physical activity, desaturation during 6MWT and imbalance of inflammatory response in patients with COPD combined with hypertension.Item Role of VEGF in development of chronic obstructive pulmonary disease in combination with hypertension(ХНМУ, 2015-05) Istomina, OlgaNowadays lot of attention is paid to issue of comorbid disease. On the basis of progressive humanity development, it is mentioned a decline of ecological situation, reduction of human motor activity, increasing of bad habits, poor nutrition and organism senilism. All these factors are lead to formation of several disease in humans at the same time. The prevalence of comorbid pathology averages 76,6%, 82% - for women, 72% - for men. One of the most common comorbid conditions is a chronic obstructive pulmonary disease (COPD) in combination with hypertension. According to the data WHO (newsletter #310, 2014) COPD and hypertension are included to the list of ten leading death causes in the world. Hypertension is found in COPD patients with varying frequency (from 6,8% to 76,3%) with average 34,3%. On this stage endothelial dysfunction can be considered as one of the most important independents risk factors for diabetes, atherosclerosis, COPD, hypertension, sepsis and growth of malignant neoplasms. One of the main endothelium functions is vascular growth regulations. One of the angiogenesis markers is vascular endothelial growth factor (VEGF). Among the angiogenic factors family, VEGF is considered to be a major one while neovascularization. Proteins which belong to the VEGF family group are glycoproteins that stimulate the formations of new blood and lymph vessels and also increase vascular permeability. One of the main factors for comobid pathology development is hypoxia and cells structure transformation under the mechanical factors influence that initiates VEGF production. By evaluation of GOLD 2014 revision COPD is characterized by a bronchial tubes affect (obstructive bronchiolitis) so as parenchymal distruction (emphysema). There are an extremely alveolar septa thinning and significantly reducing of their vascularization while progressive capillary endothelium loss and alveolar epithelium that leads to the substitution of lung tissue by the fibrous. Hypoxia promotes HIF-1a stabilization (hypoxia inducible factor-1a) which rapidly degraded at a sufficient oxygen concentration. HIF-1a and HIF-1βb is combined under hypoxia condition. Received complex is binded to a specific sensitive to the hypoxia region of the VEGF genes and increase its expression. Isolated mechanical stretching in a cell culture can contribute to VEGF realizing. Physical activity leading to the increasing of blood flow increasing shear stress and endothelial cells transformation followed by not only by increased VEGF level but also by increasing VEGFRs amount. A growth of shear stress and activation of the renin-angiotensin-aldosterone system while hypertension is also associated with increased VEGF content by mechanical influence on the vascular endothelial cells and angiotensin 2 interaction with angiotensin first type receptors which leads to the expression HIF-1a growth and increasing of VEGF synthesis. Thus VEGF and its receptors can be involved in many processes while COPD and hypertension, such as: airway walls remodeling, endothelial cell apoptosis and vascular remodeling.Item Special features of leukocyte indices in hypertensive patients with obesity(2016) Shelest, Borys; Шелест, Борис ОлексійовичItem Which patient characteristics are associated with exerciseinduced desaturation in COPD combined with hypertension?(2023-10) Melenevych, AnastasiiaWe analyzed associations between various patient characteristics and exercise-induced desaturation in chronic obstructive pulmonary disease (COPD) combined with hypertension. We found that the male sex, dyspnea, fatigue, the distance walked in the 6-min walk test, BODE index, quality of life (assessed using a Clinical COPD Questionnaire) are associated with exercise-induced desaturation in patients with COPD combined with hypertension stage II.Item Особенности динамики эндотелиальной дисфункции под влиянием терапии у больных хронической болезнью почек с артериальной гипертензией(2013-11-22) Капустник, Валерий Андреевич; Костюк, Инна Федоровна; Шелест, Борис Алексеевич; Полищук, Виктор Трофимович; Kapustnik, Valeriy; Kostyuk, Inna; Shelest, Borys; Polischyuk, ViktorОдним из важных постоянно присутствующих механизмов развития хронической болезни почек есть усиление вазоконстрикторных реакций за счет формирования дисфункции эндотелия. Остается не до конца изученным вопрос о наиболее эффективных воздействиях на эндотелиальную дисфункцию при ХБП с АГ. Цель сравнение эффективности лизиноприла с кандесартаном в отношении динамики фактора Вилллебранда и S–нитрозотиолов у пациентов с ХБП и АГ. Первая подгруппа получала лизиноприл 10 мг/сут, вторая − получала кандесартана по 8 мг/сут. Уровень S-нитрозотиолов у пациентов с ХБП и АГ при лечении лизиноприлом увеличился на 10,03% (р>0,1) до 0,139±0,038 ммоль/л. Применение кандесартана приводило к повышению содержания метаболитов оксида азота (S-нитрозотиолов) на 12,23% (р>0,1). Лизиноприл и кандесартан в течение 2-х месяцев приводили к снижению уровня фактора Виллибранда и повышению S-нитрозотиолов, таким образом, улучшая функцию эндотелия у обследованных больных. Одним из механизмов действия лизиноприла и кандесартана является способность уменьшать содержание фактора Виллебранда в крови, причем более выражено у лизиноприла. Increased vasoconstrictor reactions are the most important ever present mechanisms of chronic kidney disease and are developed due to the formation of endothelial dysfunction. The most effective therapeutic influences on endothelial dysfunction in CKD with hypertension remains an under-researched. The purpose is to estimate the effectiveness of candesartan vs lisinopril regarding the dynamics Willebrand factor and S-nitrosothiols in patients with chronic kidney disease and hypertension. The first subgroup was prescribed lisinopril 10 mg/day, the second one took candesartan 8 mg/day. The level of S-nitrosothiols increased on 10.03% (p>0.1) to 0,139±0,038 mg/dL in patients with chronic kidney disease and hypertension on lisinopril treatment. Usage of candesartan caused an increase in nitric oxide (S-nitrosothiols) to 12.23% (p>0.1). Treatment by lisinopril and candesartan for 2 months resulted in lower levels of von Willebrand factor and increased S-nitrosothiols, thereby improving endothelial function in the patients examined. One of the mechanisms of action of candesartan and lisinopril is the ability to reduce the content of von Willebrand factor in the blood.Item Сравнительный анализ корреляций между показателями метаболизма у больных при сочетанном течении вибрационной и гипертонической болезни(2014) Капустник, Валерій Андрійович; Капустник, Валерий Андреевич; Kapustnik, Valeriy; Сухонос, Наталія Костянтинівна; Сухонос, Наталия Константиновна; Sukhonos, NataliaЦелью исследования была оценка динамики напряженности иммунной и нейро-эндокринной систем у больных вибрационной болезнью (ВБ) в сочетании с гипертонической болезнью (ГБ) методом корреляционной адаптометрии. В исследование были включены n=107 больных с диагнозом ВБ от воздействия локальной вибрации I и II степени в сочетании с гипертонией (n=60) и без нее (n=47), которых распределили по 4 группам: ВБ-I (I гр., n=21); ВБ-II (II гр., n=26); ВБ-I+ГБ (III гр., n=26); ВБ-II+ГБ (IV гр., n=34). Контрольную группу составили 22 практически здоровых мужчин. В работе использованы 27 физиологических показателей метаболического состояния (иммунная, нейро-эндокринная системы) больных. Проведен анализ парной корреляции параметров по Спирману с помощью пакета прикладных программ SPSS v.13. Установлено наличие «эффекта группового стресса» у больных ВБ по сравнению с группой контроля: увеличенное количество достоверных корреляционных связей свидетельствует о существенной напряженности в деятельности иммунной, нейро-эндокринной систем и маркерных метаболических показателей у больных ВБ. Степень связанности анализируемых параметров оценивали с помощью веса корреляционного графа. Установлено однотипное поведение веса корреляционного графа для обследованных групп больных GВБ-I>GВБ-II>GВБ-I+ГБ>GВБ-II+ГБ. Результаты свидетельствуют о том, что ГБ как дополнительная нагрузка для организма усугубляет адаптационные возможности и приводит к срыву гомеостатических функций организма (структурные и функциональные нарушения нейро-эндокринной регуляции), причем у категории больных ВБ-II+ГБ происходит дополнительное подавление функциональной активности иммунной и нейро-эндокринной систем. Использование результатов корреляционной адаптометрии как информации об адаптационных перестройках в организме рабочих предприятий с вредными условиями представляется целесообразным в разработке профилактических мероприятий. Ціллю дослідження була оцінка динаміки напруженості імунної та нейро-ендокринної систем у хворих на вібраційну хворобу (ВХ) в поєднанні з гіпертонічною хворобою (ГХ) за методом кореляційної адаптометрії. У дослідження включено n=107 хворих з діагнозом ВХ від дії локальної вібрації I и II ступеня у поєднанні з ГХ (n=60) та без неї (n=47), які були розподілені на 4 групи: ВХ-I (I гр., n=21); ВХ-II (II гр., n=26); ВХ-I+ГХ (III гр., n=26); ВХ-II+ГХ (IV гр., n=34). Контрольну групу склали 22 практично здорових чоловіків. В роботі використовано 27 фізіологічних показників метаболічного стану (імунна, нейро-ендокринна системи) хворих. Проведено аналіз парної кореляції параметрів за Спирманом за допомогою пакета прикладних програм SPSS v.13. Встановлено наявність «ефекту групового стресу» у хворих на ВХ у порівнянні з контролем: збільшена кількість вірогідних кореляційних зв’язків свідчить про значну напруженість в діяльності імунної, нейро-ендокринної систем та маркерних метаболічних показників у хворих на ВХ. Ступінь пов’язанності аналізованих параметрів оцінювали за допомогою ваги кореляційного графа. Встановлено однотипову поведінку ваги кореляційного графа для обстежених груп хворих GВБ-I>GВБ-II> GВБ-I+ГБ>GВБ-II+ГБ. Результати свідчать про те, що ГХ як додаткове навантаження на організм послабляє адаптаційні можливості й призводить до зрушення гомеостатичних функцій організму (структурні та функціональні порушення нейро-ендокринної регуляції), причому у категорії хворих на ВХ-II+ГХ здійснюється додаткове пригнічення функціональної активності імунної та нейро-ендокринної систем. Використання результатів кореляційної адаптометрії як інформації про адаптаційні перебудови в організмі працівників підприємств зі шкідливими умовами здається доцільним у розробці профілактичних заходів. The estimation of the immune and neuro-endocrine systems tension dynamics in patients with vibrational disease (VD) in combination wsth hypertension (H) by a method of the correlation adaptometry is the aim of this investigation. There were n=107 patients with different stages (I; II) of VD in combination with (H) (n=60) and without it (n=47). Among these patients it was choosed 4 groups: I gr., n=21 – VD-I; II gr., n=26 – VD-II; III gr., n=26 – VD-I+H; IV gr., n=34 – VD-II+H. Control group had 22 apparently healthy men. In the work we used 27 physiological indices of the patients metabolic state (immune, neuro-endocrine systems). It was carried out analysis of the twin correlation of indices by Spirman with help of program SPSS v.13. It was determined the presence of the “group stress effect” in the patients with VD in comparison with control: increasable number of the reliable correlative connections testifies about significant tension in immune, neuro-endocrine systems and metabolic indices in VD patients. We estimated the degree of the binding of parameters by correlative graph weight. It was determined of the some kind behavior of the correlative graph weight for the different groups patients GVD-I>GVD-II>GVD-I+H>GVD-II+H. Hypertension as an additional load on organism reduces the adaptic possibilities and causes breach of the organism’s homeostatic functions (structural and functional disorders of the neuro-endocrine regulation), especially in VD-II+H group. Utilization of the correlation adaptometry results as information about adaptic changes in workers of unhealthy trade is expedient in disease-prevention service.