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ISSN 2310-8363

Репозитарій Харківського національного медичного університету – це відкритий електронний архів академічних текстів, матеріалів наукового та навчально-методичного призначення, створених науковцями, викладачами, іншими працівниками університету та здобувачами

З усіх питань щодо Репозитарію ХНМУ звертайтеся до координатора Тетяни Павленко за адресою: repository@knmu.edu.ua

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Medical aspects of bacterial stigmergy
(2026) Morozova, Nelli; Marievskyi, Victor; Korobkov, Irina; Golovchak, Grigory; Popov, Oleksandr; Balko, О.; Balko, О.
Th e article highlights current data on the medical aspects of bacterial stigmergy problem, which is considered a phenomenon of collective self-organization of bacterial communities in response to the infl uence of adverse environmental factors. Th e transformation of bacteria into various adaptive forms is a phenomenon that is not only repeated in in vitro experiments but also is quite oft en a form of bacterial existence in the human body. A number of forms of bacterial stigmergy are discussed, such as biofi lm formation, uncultivated forms of bacteria, microorganisms with a defect in cell wall synthesis, and a motile colony morphotype that can exist in the patient’s organism at diff erent stages of the infectious process. Analysis of clinical data shows that under most diseases, pathogens can acquire certain forms of resistance, while in some cases, for example, in typhoid fever, the origin of multifactorial protection is observed with the formation of uncultivated and L-forms, as well as a “motile” morphotype of colonies. Th e role of adaptively modifi ed forms in the development of chronic and recurrent infections is considered.
Regulation of tissue insulin sensitivity as a mechanism of functional priority: implications for adaptation, survival, and rehabilitation
(2026) Biletska, Olga; Garyachiу, Yevgeniy; Shevchenko, Alexander
Background. Insulin Resistance (IR) is traditionally regarded as one of the key mechanisms underlying metabolic syndrome, type 2 diabetes mellitus, and associated cardiovascular complications. However, alterations in insulin sensitivity also occur during fasting, physical exercise, pregnancy, acute stress, trauma, and inflammation, suggesting their potential adaptive role in the regulation of energy metabolism. Aim. To summarize current evidence on the role of tissue insulin sensitivity in systemic immunometabolic adaptation and to substantiate the concept of its regulation as a mechanism of functional priority. Materials and Methods. A literature search for the narrative review was conducted in PubMed, Scopus, Web of Science, and Google Scholar. Data synthesis was performed using conceptual and integrative approaches. The study was carried out as a private initiative of the authors, without grant support and state registration of the topic. Research Ethics. Only sources that complied with current bioethical standards were selected for the analysis. Results. Available evidence indicates that alterations in insulin sensitivity are tissue-specific and may serve adaptive functions. During acute inflammation, activation of the cytokine network, the hypothalamic-pituitary-adrenal axis, the sympathoadrenal system, and other counter-regulatory mechanisms is accompanied by stress hyperglycemia, mobilization of energy substrates, and selective reduction of insulin sensitivity in skeletal muscle and adipose tissue. These changes increase the availability of energy resources for innate immune cells, the central nervous system, and other vital structures. Regulation of tissue insulin sensitivity is proposed as a mechanism of functional priority that ensures redistribution of resources according to the organism's adaptive needs. The concept of immunometabolic allostasis is substantiated, according to which insulin resistance may represent not only a manifestation of metabolic pathology but also a component of a coordinated adaptive response. Acute post-traumatic and low-grade sterile inflammation associated with metabolic syndrome appear to share common mechanisms of neuroendocrine regulation. Conclusions. Tissue insulin sensitivity may be regarded as an important component of systemic immunometabolic adaptation. The proposed concept of functional priority provides a basis for considering the regulation of insulin sensitivity as one of the mechanisms involved in the redistri-bution of energy resources among functional systems according to their importance for adaptation, survival, and recovery.
Соціальна робота в державних та недержавних соціальних інституціях
(2026) Могилка, Олександр Петрович; Костіна, В.В.; Тєрьошина, Ірина Федорівна
Залучення здобувачів освіти до заходів університету - подолання викликів війни
(2026) Томіліна, Тетяна Вікторівна; Старкова, Ірина Володимирівна; Троценко, Алексей Владимирович; Старкова, Виолетта Дмитриевна
Виклик, що надає війна, обмежуючи соціалізацію майбутніх лікарів при навчанні, можливо подолати при залученні здобувачів освіти до заходів, які відбуваються у закладі вищої освіти.
Incidence and outcomes of postoperative complications after liver cirrhosis - related surgery
(2026) Petiunin, Oleksii; Syplyviy, Vasyl; Al Mashni, Kamel Jbarah Hammad; Myroshnychenko, Dmytro; Makarov, Vitaly; Novikova, Anna; Porovai-Nevoit, Bohdan