DSpace Repository

ISSN 2310-8363

Репозитарій Харківського національного медичного університету – це відкритий електронний архів академічних текстів, матеріалів наукового та навчально-методичного призначення, створених науковцями, викладачами, іншими працівниками університету та здобувачами

З усіх питань щодо Репозитарію ХНМУ звертайтеся до координатора Тетяни Павленко за адресою: repository@knmu.edu.ua

Communities in DSpace

Select a community to browse its collections.

Now showing 1 - 19 of 19

Recent Submissions

Європейський стандарт комп'ютерної грамотності: підручник
(2026) Зайцева, Ольга Василівна; Бондаренко, Марина Анатолівна; Солодовніков, Андрій Сергійович
The role of information and communication technologies in addressing current challenges in primary health care
(Харківський національний університет імені В. Н. Каразіна, 2026) Zhelezniakova, Natalia; Aleksandrova, Tetiana
Neutrophil Gelatinase-Associated Lipocalin (NGAL) As A Marker Of Renal Damage In Patients With Arterial Hypertension And Type 2 Diabetes Mellitus
(SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv, Ukraine, 2026) Kravchun, Nonna; Dunaeva, Inna; Kravchun, Pavlo; Tykha, I.; Kryvoshapka, Oleksandr; Doroshenko, Oksana; Pautina, Olena
Introduction. The combination of arterial hypertension (AH) and type 2 diabetes mellitus (T2DM) is as-sociated with an increased risk of target organ damage, particularly renal injury, which necessitates the search for early biomarkers of subclinical damage. Neutrophil gelatinase-associated lipocalin (NGAL) is considered a promising marker of early nephropathic and cardiometabolic changes; however, its relationships with clinical and metabolic parameters in AH, especially when combined with T2DM, remain insufficiently studied. Aim. To investigate clinical, laboratory, immunological, biochemical, and hemodynamic factors and to determine their association with NGAL levels in patients with arterial hypertension with and without type 2 diabetes mellitus. Materials and Methods. The study included 136 patients with AH, divided into two groups: the first group comprised patients with isolated AH (n = 64), and the second group comprised patients with AH combined with T2DM (n = 72). The control group consisted of 20 apparently healthy individuals. All participants under-went clinical, biochemical, immunological, and instrumental examinations, including assessment of lipid profile, HbA1c, insulin, cystatin C, leptin, NT-proBNP, and NGAL by ELISA; evaluation of lymphocyte subpopulations, renal function indices, and echocardiographic parameters. Statistical analysis was performed using correlation and stepwise multiple regression. Results. Patients with combined AH and T2DM demonstrated a more unfavourable metabolic profile, with increased BMI, total cholesterol, triglycerides, and atherogenic coefficient, as well as activation of the cel-lular immune response and more pronounced myocardial remodeling. NGAL levels did not differ significantly between the groups (p > 0.05). Stratification by the median NGAL level showed a significant increase in leptin (p = 0.011) and a decrease in insulin (p = 0.009) in patients with higher NGAL values. According to stepwise regression analysis, independent predictors of NGAL in patients with AH were HbA1c, urea level, insulin level, and diastolic blood pressure (R²=0.31; p<0.0139). In patients with AH + T2DM, the model demonstrated grea- ter explanatory power (R² = 0.37; p < 0.035) and included metabolic, immunological, and echocardiographic parameters. Conclusions. NGAL levels in patients with arterial hypertension are shaped by a complex set of metabolic, immunological, and hemodynamic factors. In the presence of concomitant type 2 diabetes mellitus, the spect-rum of determinants expands to include indicators of myocardial remodeling and immune activation. NGAL is associated with disturbances in adipokine regulation and insulin homeostasis and may be considered an inte-gral biomarker for early subclinical target-organ damage and for cardiometabolic risk stratification.Key words: arterial hypertension, type 2 diabetes mellitus, NGAL, cardiometabolic risk, HbA1c, insulin.
Contemporary legal issues in bioethics: genetic engineering and end-of-life decisions
(2026) Kapustnyk, Volodymyr; Vlad, Vadym; Klochko, lona; Lahodych, Mykola; Ternavska, Anastasiia
The rapid development of genetic engineering and the expansion of end-of-life decision-making practices generate complex legal and bioethical dilemmas that directly affect fundamental human rights. These developments create tensions between scientific progress, the state’s obligation to protect life, and the need to respect individual autonomy. The absence of unified legal approaches to regulating biomedical practices highlights the necessity for systematic analysis of international and supranational standards. This study aims to identify and characterize contemporary legal dilemmas in genetic engineering and euthanasia within a bioethical framework, while clarifying the limits of permissible regulation based on human dignity and personal autonomy. The research focuses on legal mechanisms governing biomedical interventions at international and supranational levels and applies theoretical-analytical and normative methods, including the examination of conventions, recommendations, and judicial practice. The findings demonstrate that regulation of genetic engineering operates as a multi-level system of substantive and procedural safeguards, with human dignity as a key limiting principle. Individual autonomy gains legal significance when exercised through structured procedures such as informed consent and ethical oversight. Furthermore, judicial practice increasingly frames autonomy as a procedural standard balancing the protection of life with self-determination, contributing to the development of coherent governance standards.
The Effect of Maternal Autonomic Regulation on fetal Hemodynamic Fluctuations and Growth
(Bucharest College of Physicians, 2026) Lakhno, Igor
Objective. The development of fetal autonomic regulation has a crucial influence on fetal hemodynamics. Heart rate variability (HRV) captures the continual changes in sympathetic and parasympathetic balance. The study was focused on the detection of the relationship between maternal HRV, fetal HRV, neonatal biometry, and Apgar score. Methods. This study was performed among 71 pregnant women at 22-36 weeks. Fetal HRV data were collected using non-invasive fetal electrocardiography (NI-FECG) with the “Cardiolab Baby Card” system, which registered RR-intervals from the maternal abdominal wall over 30–60 minutes. Additionally, the study recorded neonatal biometry (birth weight, body length, and head circumference) and the 1-minute Apgar score. Results. Maternal stress index (SI) demonstrated strong or moderate negative correlation with acceleration capacity (AC) maternal (r=-0.71; p<.001), deceleration capacity (DC) maternal (r=-0.78; p<.001), AC fetal (r=-0.42; p<.001), DC fetal (r=-0.37, p=.001), and STV (r=-0.27, p=.022). A positive moderate correlation was found in pairs Apgar score vs AC fetal (r=0.31; p=.009), DC fetal vs Apgar score (r=0.35, p=.003), STV (r=0.27; p=.024), and LTV (r=0.25; p=.038). A negative moderate correlation was detected between the SI fetal and Apgar score (r=-0.27; p=0.02). The multivariate logistic regression detected the relationship between maternal SI and neonatal body weight. Conclusion. Maternal stress-related sympathetic activity is intrinsically linked to fetal autonomic regulation and neonatal outcomes. Utilizing maternal SI as a prognostic marker could provide clinicians with a fundamental tool for developing models to predict fetal growth restriction and ensure timely intervention.