Interleukin-18/interleukin-10 ratio in predicting the further course of chronic obstructive pulmonary disease combined with hypertension

Abstract

The article presents the results of analysis of main prognostically significant criteria depending on the values of interleukin-18/interleukin-10 (IL-18/IL-10) ratio in patients with chronic obstructive pulmonary disease (COPD) combined with hypertension (HT). Growth of IL-18/IL-10 ratio was associated with emphysematous changes in chest X-ray, increase in the degree of dyspnea, decreased exercise tolerance, increased levels of desaturation, lower body mass index, waist and mid-arm circumferences. The results of echocardiography revealed that all patients with comorbid pathology had signs of myocardial overload. Patients of the first tertile (IL-18/IL-10 < 23) had more pronounced signs of an overload of the left heart. Instead, patients of the third tertile (IL-18/IL-10 ≥ 59) had more pronounced signs of an overload of the right heart by pressure. Prognostically unfavorable types of left ventricular geometry (concentric hypertrophy and eccentric hypertrophy) were more common in patients of the first tertile.