Clinical COPD Questionnaire results depending on the degree of the inflammatory response in patients with COPD combined with hypertension

Abstract

Little is known about the relationship between Clinical COPD Questionnaire (CCQ) score and degree of the inflammatory response in patients with COPD combined with hypertension (HT). We analyzed CCQ scores depending on the 6-min walk test (6MWT) and pulse oximetry data. An inverse correlation was found between the distance walked in 6MWT and the total CCQ score (r=-0,74; p<0,05); the functional state domain score (r=-0,75; p<0,05); the symptom domain score (r=-0,48; p<0,05) and the mental state domain score (r=-0,46; p<0,05). A direct correlation was found between desaturation and the total CCQ score (r=0,66; p<0,05); the functional state domain score (r=0,77; p<0,05) and the mental state domain score (r=0,41; p<0,05).We investigated serum IL-18 and IL-10 levels in 69 COPD (GOLD 2, group B) patients in remission in combination with HT stage II (57 males and 12 females; mean age 55,80±5,51 years). Patients were divided into three groups – tertiles, depending on the level of IL-18/IL-10 ratio. It was found that the growth of IL-18/IL-10 ratio significantly (p<0,001) associated with increasing the functional state domain score. The mean score of the functional state CCQ domain in patients of the 1st tertile was 2,38, 2nd - 2,50 and 3rd - 3,21.Thus, the functional state CCQ domain score significantly represented the imbalance between IL-18 and IL-10 in COPD with HT patients.