Наукові праці. Кафедра медичної та біоорганічної хімії
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Item 1,3,7-trimethylxanthine – known adjuvant of non-steroidal anti-inflammatory drugs of different chemical structures(European Academy of Science, 2018-11-30) Syrovа, Ganna; Lukianova, Larysa; Chalenko, NataliaItem 4'-карбетоксіанілід 4,6-дибром-2-карбоксисукцинанілової кислоти, який проявляє нейролептичну, антигіпоксичну, протизапальну, анальгетичну, діуретичну та фунгістатистичну активність(2014-06-10) Ісаєв, Сергій Григорович; Гриценко, Іван Семенович; Алферова, Діана Олександрівна; Яременко, Віталій Дмитрович; Сирова, Ганна Олегівна; Жегунова, Галина Петрівна; Алексєєва, Тетяна МихайлівнаItem 5,11,17,23-тетра(n-ациламідо)-25,26,27,28-тетраалкоксикалікс[4]арени з біофорними фрагментами 2,4-дихлорбензойної та 2-(4-ізобутилфеніл)пропіонової кислоти(2018-05-10) Родік, Роман Васильович; Чаленко, Наталія Миколаївна; Сирова, Ганна Олегівна; Кальченко, Віталій ІвановичItem 6-нітро- та 4,5-диметокси-N-(2'-карбокси-4'-бромфеніл) антранілові кислоти, які проявляють протизапальну, анальгетичну, діуретичну та протигрибкову активність(2014-06-10) Ісаєв, Сергій Григорович; Девяткіна, Анна Олександрівна; Єрьоміна, Ганна Олександрівна; Бризицький, Олексій Аркадійович; Сирова, Ганна Олегівна; Жигунова, Галина ПетрівнаItem A parallel liquid-phase synthesis of 5-(1H-4-pyrazolyl)-[1,2,4]oxadiazole libraries(American Chemical Society, 2009) Borisov, Aleksandr; Detistov, Oleksandr; Pukhovaya, Viktoriya; Zhuravel, Irina; Kovalenko, SergeiCombinatorial libraries of substituted 3-(methylthio)-5-(amino)-4-([1,2,4]oxadiazol-5-yl)-1H-pyrazoles 6,10, 13, 15 (395 members, yields 32-87%), 4-([1,2,4]oxadiazol-5-yl)-1H-3,5-pyrazolediamines 8, 11 (571 members, yields 25-83%), 2-(methylthio)-3-([1,2,4]oxadiazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-ones 17(85 members, yields 56-95%), and 2-(amino)-3-([1,2,4]oxadiazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-ones 18 (110 members, yields 56-95%) were synthesized by the parallel liquid-phase synthesis method.Item Academic integrity in higher education(Potere della ragione Editore. Rome, 2021-02) Levashova, Olga; Tishakova, TetyanaItem Age-dependent change in aldo-keto reductases composition in the blood of rats(Science Publishing Group, 2014-08-20) Davydov, Vadim; Bozhkov, Anatoliy; Grabovetskaya, EvgeniyaResistance of the organism to the stress injury changes during ontogenesis. In this regard, the incidence of cardiovascular, central nervous, endocrine systems, etc. increases at certain stages of individual development. Taking into account the fact that the development of stress-caused lesions is associated with accumulation of carbonyl products of free radical oxidation in cells, we have suggested that the one of the reasons for this phenomenon is age-related changes in the efficiency of the scavenging of endogenous aldehydes in the organism. In view of this fact, spectrum of aldo-keto reductases in blood serum of rats at different stages of ontogenesis was investigated by means of electrophoresis. Identical changes in the composition of aldo-keto reductases spectrum of blood in early immature age and in aging have been shown. Change in aldo-keto reductases spectrum modulates the role of reductive pathway of endogenous aldehydes scavenging in the organism. Thus, in child age and aging efficiency of scavenging of carbonyl products of free radical oxidation in cells is limited and especially when they are intensively produced. This results in increase of the susceptibility of the organism to oxidative stressItem Age-dependent peculiarities modulation of activity of aldehyde scavenger enzymes in mitochondria of rat thigh muscle during stress(2016) Davydov, Vadim; Grabovetskaya, Evgeniya; Hamdallah, AmjadThe purpose of this study was a comparative investigation of activity of aldehyde scavenger enzymes in mitochondrial fraction of a thigh muscle in intact and immobilized rats of different ages. It has been shown that 12-month-old (adult) rats have high basal levels of aldehyde dehydrogenase, aldehyde reductase and glutathione transferase activity in mitochondrial fraction of thigh muscle. Aldehyde dehydrogenase activity increases during immobilization stress in adult rats. This change promote to enhance the effectiveness of utilization of carbonyl products of free radical oxidation in mitochondria of skeletal muscle of 12-month-old rats during stress. Immobilization of old and pubertal rats is accompanied by metabolic preconditions leading to accumulation of endogenous aldehydes in mitochondria, and, as a result, to the injury of muscular fibers and intensification of sarcopenia manifestations.Item Age-related peculiarities of change in content of free radical oxidation products in muscle during stress(2014-08) Davydov, Vadim; Hamdallah, Amjad; Grabovetskaya, EvgeniyaThe age-dependent peculiarities of stimulation of free radical processes in subcellular fractions of skeletal muscle of rats subjected to long-term immobilization stress were studied in order to improve knowledge about changes of muscular tissue during ontogenesis. It is found that adult animals do not show accumulation of proteins carbonyls, TBA-reactive substances, and Schiff bases in subcellular fractions of the thigh muscle when immobilized. Long-term immobilization causes apparent manifestation of oxidative stress only in mitochondrial fraction in pubertal rats. Mitochondrial oxidative stress defense systems are sufficiently effective, however, direction of pathways of free radical oxidation carbonyl products catabolism alters in the cytoplasm of myocytes in old rats under long-term immobilization conditions.Item Allostatic response of the living organism on the toxic influence of Hydroxyethylated Alkyl- and Isononylphenols(2012) Nakonechnaya, Svetlana; Zovsky, Vyacheslav; Naglov, AleksandrThe effect of neonols АФ 9-12 and АФС 9-6 КМ on peculiarities of response of the animal organism to the toxic stress in a subacute experiment on white Wistar rats has been studied. A pronounced effect on the dynamics of catecholamines and their precursors, and also significant decrease in blood cell composition are discovered. Leukocytes are found to be the most damaged system for both xenobiotics. The toxic doses are set at 1/10 and 1/100 DL50. The long-term administration of toxicants causes allostatic response type as a sustainable stabilization of the functional state of the organism starting from 30 days.В работе изучено влияние неонолов марок АФ 9-12 и АФС 9-6 КМ на особенности ответа животного организма на токсическую нагрузку в условиях подострого эксперимента на белых крысах популяции Вистар. Обнаружено выраженное действие токсикантов на динамику катехоламинов и их предшественников, а также существенное уменьшение клеточного состава крови. Наиболее чувствительной системой для обоих марок ксенобиотиков являются лейкоциты. Действующие дозы, определеные на уровнях 1/10 и 1/100 DL50, вызывают при длительном введении аллостатический тип ответа в виде устойчивой стабилизации функционального состояния организма, начиная с 30 суток.Item Analys of hydroxycinnamic acids pulsatilla pratensis (l.) mill(Medical University Varna, Bulgaria, 2017-10-27) Savelieva, Elena; Vladymyrova, Inna; Levashova, Olga; Shumova, GannaItem Anti-Inflammatory Effect of Coxibs and their Compositions with Caffeine on the Level of Conjugated Dienes in the Formalin-Induced Edema Model(Turkish Chemical Society, 2022) Syrova, Ganna; Petiunina, Valentina; Savelieva, Olena; Tishakova, Tetyana; Lukianova, LarysaThe development of novel pharmaceutical compositions, which are effective in the treatment of different inflammatory diseases and have a minimum number of side effects is very relevant. The aim of the present study was biochemical confirmation of anti-inflammatory activity of new pharmaceutical compositions comprising coxibs and caffeine. The level of conjugated dienes as primary products of lipid peroxidation has been evaluated in the plasma of rats at the acute inflammation caused by formalin. The white male rats of WAG line were used. The content of conjugated dienes was determined by spectrophotometric method. It was shown that combinations of caffeine and coxibs showed statistical significant decrease in the content of conjugated dienes in the rats’ blood plasma. Caffeine enriched anti-inflammatory action of coxibs effectively.Item Application of carboxytherapy in dermatology(Pharmocologyonline, 2021) Drogovoz, Svitlana; Kononenko, Anna; Syrova, Ganna; Stoletov, Yu.; Glushchenko, A.; Kucherenko, E.; Sirenko, O.; Ostapets, M.Item Application of Conservative Therapy and Prediction of its Efficiency in Patients with Adhesive Peritoneum Disease Complicated with Acute Intestinal Impairment(Scholars Research Library, 2017-06) Boyko, Valeriy; Evtushenko, Denis; Mаkаrov, Vitaliy; Mаkаrov, Vladimir; Syrovaya, Anna; Kozub, Svitlana; Petunina, ValentinaConservative methods of treatment were conducted for 110 patients. Naso-intestinal endoscopic intubation of the small intestine for decompression of the gastrointestinal tract was performed to 68 patients. The estimation of the risk group for the effectiveness of conservative measures in patients with adhesive peritoneum disease complicated by acute intestinal impairment, provides an objective choice of the type of treatment. The justification and amounts of conservative measures involving endoscopic nasointestinal intubation (ENII) of the gastrointestinal tract were determined. The resolution period of the acute intestinal impairment affected by adhesive peritoneum disease in the small risk group was 9.8 ± 3.4 h; in the group of average risk – 18.6 ± 4.4 h; all high-risk patients should be urgently operated after short-term preoperative preparation. The analysis of clinical-anamnestic instrumental data following by the determination of the effectiveness of conservative measures has allowed to reduce the lethality of patients with adhesive peritoneum disease complicated by acute intestinal impairment to 1.8%.Item Application of direct coulometry for rapid assessment of water quality in Krasno-Oskol Reservoir (Kharkiv Region, Ukraine)(2016) Loboichenko, Valentyna; Tishakova, Tatyana; Vasyukov, AleksandrRegulatory regional and international requirements concerning water quality, particularly mineralization (TDS), have been considered in this article. Analysis of water Krasno-Oskol Reservoir (Kharkiv oblast, Ukraine) has been performed by applying conductometric method. It has been demonstrated that water of Krasno-Oskol Reservoir is physiologically full and conform to the international and national standards in respect to mineralization.Item Application of direct coulometry for rapid assessment of water quality in Krasno-Oskol Reservoir (Kharkiv Region, Ukraine)(2016-11-22) Loboichenko, Valentyna; Tishakova, Tatyana; Vasyukov, VasyukovRegulatory regional and international requirements concerning water quality, particularly mineralization (TDS), have been considered in this article. Analysis of water Krasno-Oskol Reservoir (Kharkiv oblast, Ukraine) has been performed by applying conductometric method. It has been demonstrated that water of Krasno-Oskol Reservoir is physiologically full and conform to the international and national standards in respect to mineralization.Item Application of log-logistic distribution for calculations of thermodynamic parameters(2019-04-19) Kozub, Pavlo; Migunov, V.; Kozub, SvitlanaItem Assessment of the biological effect of Cu nanoparticles impregnated in polyethylene medical devices combined with the effect of LED radiation of the red and violet spectra on the ability of microorganisms to form biofilms and on daily biofilms(Journal of Education, Health and Sport., 2021) Mishyna, Maryna; Hopta, Olha; Syrova, Ganna; Avramenko, Vyacheslave; Mozgova, Yuliya; Malanchuk, Svitlana; Makarov, Volodymyr; Dubovik, Olena; Marchenko, Irina; Mishyn, YuriyItem Bioactive Components of Soybean as a Source of Medicinal Products(2017-07) Levashova, Olga; Gaponenko, Valentina; Syrovaya, Anna; Gontova, TetianaThis article presents the results of qualitative and quantitative composition of biologically active substances of green mass 6 recognized varieties of soybean, soybean seeds, soybean meal after oil extraction and biologically active complex of soy. The presence of 21 amino acids, 7 flavones, 6 isoflavones, 2 coumarin, 4 phenolcarbonic acid, tannins, vitamins (E, K, P, B), polysaccharides was determined. The resource-saving technology of oil production, biologically active complex and protein were developed.Item Biochemical and planimetric investigations of hydrophilic creams containing ceramides or dexpanthenol on the model of chemical burns(2023-04-14) Butko, Yaroslava; Tishakova, Tetyana