Age-related peculiarities of change in content of free radical oxidation products in muscle during stress
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Date
2014-08
Authors
Davydov, Vadim
Hamdallah, Amjad
Grabovetskaya, Evgeniya
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Abstract
The age-dependent peculiarities of stimulation of free radical processes in subcellular fractions of skeletal muscle of rats subjected to long-term immobilization stress were studied in order to improve knowledge about changes of muscular tissue during ontogenesis. It is found that adult animals do not show accumulation of proteins carbonyls, TBA-reactive substances, and Schiff bases in subcellular fractions of the thigh muscle when immobilized. Long-term immobilization causes apparent manifestation of oxidative stress only in mitochondrial fraction in pubertal rats. Mitochondrial oxidative stress defense systems are sufficiently effective, however, direction of pathways of free radical oxidation carbonyl products catabolism alters in the cytoplasm of myocytes in old rats under long-term immobilization conditions.
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Keywords
ontogenesis, stress, skeletal muscle, free radical oxidation
Citation
Davydov V. V. Age-related peculiarities of change in content of free radical oxidation products in muscle during stress / V. V. Davydov, A. Hamdallah, E. R. Grabovetskaya // Frontiers in Biology. – 2014. – Vol. 9, issue 4. – P. 283–286.