Anti-Inflammatory Effect of Coxibs and their Compositions with Caffeine on the Level of Conjugated Dienes in the Formalin-Induced Edema Model
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Date
2022
Authors
Syrova, Ganna
Petiunina, Valentina
Savelieva, Olena
Tishakova, Tetyana
Lukianova, Larysa
Journal Title
Journal ISSN
Volume Title
Publisher
Turkish Chemical Society
Abstract
The development of novel pharmaceutical compositions, which are effective in the treatment of different inflammatory diseases and have a minimum number of side effects is very relevant. The aim of the present study was biochemical confirmation of anti-inflammatory activity of new pharmaceutical compositions comprising coxibs and caffeine. The level of conjugated dienes as primary products of lipid peroxidation has been evaluated in the plasma of rats at the acute inflammation caused by formalin. The white male rats of WAG line were used. The content of conjugated dienes was determined by spectrophotometric method. It was shown that combinations of caffeine and coxibs showed statistical significant decrease in the content of conjugated dienes in the rats’ blood plasma. Caffeine enriched anti-inflammatory action of coxibs effectively.
Description
Keywords
Celecoxib, rofecoxib, caffeine, conjugated dienes, non-steroidal anti-inflammatory drugs
Citation
Anti-Inflammatory Effect of Coxibs and their Compositions with Caffeine on the Level of Conjugated Dienes in the Formalin-Induced Edema Model / G. Syrova, V. Petiunina, O. Savelieva, T. Tishakova, L. Lukianova // Journal of the Turkish Chemical Society. – 2022. – Volume 9, issue 4. – Р. 1029–103.