A parallel liquid-phase synthesis of 5-(1H-4-pyrazolyl)-[1,2,4]oxadiazole libraries
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Date
2009
Authors
Borisov, Aleksandr
Detistov, Oleksandr
Pukhovaya, Viktoriya
Zhuravel, Irina
Kovalenko, Sergei
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
Abstract
Combinatorial libraries of substituted 3-(methylthio)-5-(amino)-4-([1,2,4]oxadiazol-5-yl)-1H-pyrazoles 6,10, 13, 15 (395 members, yields 32-87%), 4-([1,2,4]oxadiazol-5-yl)-1H-3,5-pyrazolediamines 8, 11 (571 members, yields 25-83%), 2-(methylthio)-3-([1,2,4]oxadiazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-ones 17(85 members, yields 56-95%), and 2-(amino)-3-([1,2,4]oxadiazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-ones 18 (110 members, yields 56-95%) were synthesized by the parallel liquid-phase synthesis method.
Description
Keywords
[1,2,4]oxadiazoles, medicinal chemistry, parallel liquid-phase synthesis, pyrazoles, combinatorial libraries
Citation
A parallel liquid-phase synthesis of 5-(1H-4-pyrazolyl)-[1,2,4]oxadiazole libraries / A. V. Borisov, O. S. Detistov, V. I. Pukhovaya, I. O. Zhuravel, S. M. Kovalenko // J. Comb. Chem. – 2009. – Vol. 11. – P. 1023–1029.