Accordance of clinical and instrumental profile to cystatin c level in patients with stage ii hypertension and frequent extrasystole
Date
2022
Authors
Kuzminova, N.
Ivankova, A.
Lozinsky, S.
Knyazkova, I.
Ivanova, E.
Kulchytska, O.
Shkarivsky, Yu.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
156 patients with essential arterial hypertension of the II stage were examined, 124 of them had frequent symptomatic extrasystoles: 74 – of supraventricular and 50 – of ventricular origin. Another 32 patients had no arrhythmias and were a comparison group. The control group included 30 practically healthy normotensive persons. All patients underwent a complete clinical and laboratory and anthropometric examination, blood pressure measurement, daily blood pressure monitoring, daily electrocardiogram monitoring, echocardiography, and serum cystatin C determination. The value of glomerular filtration rate and the presence of paired ventricular extrasystole showed the greatest predicting level of serum cystatin C in patients with hypertension (OR 5.32 and 3.22, respectively, p<0.0001). It is proved that relatively high levels of cystatin C in patients with stage II hypertension are accompanied by the electrical instability of the left ventricular myocardium and can be considered as a marker of frequent and paired ventricular extrasystoles in these patients. Patients with hypertension with relatively high cystatin C are characterized by higher blood pressure, more severe structural remodelling of the left ventricle, and impaired renal function.
Description
Keywords
essential hypertension, extrasystole, cystatin C, cystatin ratio, cystatin background
Citation
Accordance of clinical and instrumental profile to cystatin c level in patients with stage ii hypertension and frequent extrasystole / N. V. Kuzminova, A. V. Ivankova, S. E. Lozinsky, I. I. Knyazkova, E. I. Ivanova, O. M. Kulchytska, Yu. L. Shkarivsky // World of Medicine and Biology. – 2022. – № 2 (80). – P. 89–93.