Accordance of clinical and instrumental profile to cystatin c level in patients with stage ii hypertension and frequent extrasystole

Abstract

156 patients with essential arterial hypertension of the II stage were examined, 124 of them had frequent symptomatic extrasystoles: 74 – of supraventricular and 50 – of ventricular origin. Another 32 patients had no arrhythmias and were a comparison group. The control group included 30 practically healthy normotensive persons. All patients underwent a complete clinical and laboratory and anthropometric examination, blood pressure measurement, daily blood pressure monitoring, daily electrocardiogram monitoring, echocardiography, and serum cystatin C determination. The value of glomerular filtration rate and the presence of paired ventricular extrasystole showed the greatest predicting level of serum cystatin C in patients with hypertension (OR 5.32 and 3.22, respectively, p<0.0001). It is proved that relatively high levels of cystatin C in patients with stage II hypertension are accompanied by the electrical instability of the left ventricular myocardium and can be considered as a marker of frequent and paired ventricular extrasystoles in these patients. Patients with hypertension with relatively high cystatin C are characterized by higher blood pressure, more severe structural remodelling of the left ventricle, and impaired renal function.