Active persistence of the epstein-barr virus worse prognosis esophagits in school children

Abstract

Aims: To study the effect of active persistence of EBV in school-age children with esophagitis and complicated variants of GERD, based on the results of a comprehensive study. Methods: 388 children aged 6-18 years with esophagitis were examined. The diagnosis was verified endoscopically and morphologically. Hр was determined histologically, the activity of EBV - by PCR of blood serum. The results were statistically processed. Results: The overall infection with Hp was 56%. Patients were divided into 2 groups: group 1 - 295 (76%) patients with catarrhal esophagitis, group 2 - 93 (24%) patients with erosive esophagitis. EBV in catarrhal esophagitis was detected in 12%, and in erosive esophagitis in 48% of patients (p<0.01). 24.5% of patients with erosive esophagitis had complications in the form of torpid slit-like erosions, ulcers and polyps of the esophagus. When analyzing the infection rate of this category of patients, it turned out that Hp-positive variants of complicated esophagitis accounted for only 28%, while active EBV infection was detected in 92% of patients (p<0.01). Conclusions: EBV is significantly more often detected in school-age children with erosive and complicated esophagitis. Active long-term persistence of EBV worsens the prognosis of esophagitis.