Кафедра дитячих інфекційних хвороб
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Item Clinical and paraclinical features of the adverse course of infectious mononucleosis in children(2023-02) Lysak, Diana; Shapovalova, Yevgenia; Kolesnyk, Yana; Rudyashko, NataliyaHerpesvirus infections (HVI) remain an urgent problem in modern pediatrics. First of all, this is due to their widespread distribution, the ability to persist for life with periodic activation and the transition of latent forms into manifest and generalized ones. According to WHO experts (2018), we are currently talking about a pandemic of herpes virus infections: up to 90% of the adult and child population of the planet are infected with herpes viruses (HV), while 50% of them have manifest forms of infection. Infectious mononucleosis (IM) is the most common, characteristic clinical manifestation of herpesvirus infections. The difficulties of treating patients, the formation in some cases of unfavorable variants of the course and outcomes determine the medical and social significance of this pathology.Item Features of the structural and functional state of blood lymphocytes in patients with infectious mononucleosis with different course(2023-01) Kolesnyk, Yana; Olkhovska, Olga; Sorokina, OlgaThe relevance of the problem of infectious mononucleosis (IM) is determined by the high level of Epstein-Barr virus (EBV) infection in children, the possibility of developing an unfavorable course of the disease and, in some cases, the formation of long-term immunosuppression with a deficiency of T-cell and phagocytic immunity. The available literature clearly highlights the issues of etiology, pathogenesis and clinical manifestations of the disease. However, scientists' data on the early diagnosis of infectious mononucleosis are rather contradictory. Untimely diagnosis of active forms of EBV infection, and hence untimely treatment, can lead to uncontrolled proliferation of B-lymphocytes, which is a causative factor in the malignancy of EBV-infected cells with the development of lymphoproliferative diseases.Item Clinical and immunological features of rotovirus infection in children infected with Epstein-Barr virus(2022-05) Слєпченко, Маргарита Юрівївна; Кузнєцов, Сергій Володимирович; Колесник, Яна Володимирівна; Сорокіна, Ольга Генадіївна; Sliepchenko, Marharyta; Kuznetsov, Sergey; Kolesnyk, Yana; Sorokinа, OlgaThe aim: To identify clinical and immunological features of acute rotavirus gastroenteritis occurring against the background of Epstein-Barr virus infection. Materials and methods: The study involved examination of 56 children. Of them, 33 children (1 group) did not have a background infection and 23 patients (2 group) suffered from rotavirus infection on the background of the latent form of Epstein-Barr virus infection. Children in these groups were compared by gender, age, severity of the disease and other parameters. Quantitative data were presented as mean and standard deviation (M±SD). Differences at p <0.05 were considered statistically significant. Results: The data suggest that the presence of background Epstein-Barr virus in children with rotavirus infection leads to later hospitalization, lower temperature response rates, lower frequency of vomiting at the onset of the disease, and longer duration of fever and diarrhea. At the same time, in children infected with Epstein-Barr virus, the relative content of CD8+ T lymphocytes dominated both in the acute period of the disease and in the period of convalescence against the background of reduced relative content of CD16+, CD22+ T lymphocytes and IgM in the period of early convalescence. Conclusions: The study allowed to reveal the influence of latent EBV infection on the clinical and immunological parameters of rotavirus gastroenteritis.Item Latent EBV infection as an independent predictor affecting clinical and paraclinical parameters of rotavirus infection in children(2021-03-21) Kolesnyk, Yana; Sliepchenko, Marharyta; Sorokina, OlgaDespite the widespread use of vaccination aimed at the prevention of rotavirus infection (RVI), rotavirus still remains one of the main etiological factors of intestinal infections in young children. Among the available literature there is a large number of publications devoted to the study of clinical and immunological features of RVI. However, a number of authors point to the ability of herpes infection to affect the immune response of children and the course of infectious pathology in them. Thus, some scientists have found differences in the clinical picture and immune response of children with intestinal infections in the presence of concomitant herpesvirus infection. But their conclusions are somewhat different. According to some studies, infection with herpes viruses complicates the course of intestinal infection, contributes to the prolongation of its clinical symptoms. Other authors have found an immunomodulatory effect of herpesviruses, which contributes to an easier course of infectious pathology.Item Clinical polymorphism of yersinijsis in children(2020-10-08) Makarenko, Regina; Kolesnyk, YanaItem Modern understanding of diagnosis and treatment of infectious mononucleosisin children(2021-03-17) Kolesnyk, Yana; Zharkova, Tetiana; Gubar, SergiiItem Latent EBV infection as an independent predictor affecting clinical and paraclinical parameters of rotavrus infection in children(2021-03-21) Sliepchenko, Marharyta; Kolesnyk, Yana; Sorokinа, OlgaItem Clinical and laboratory predictors of herpesvirus infection of children with rotavirus gastroenteritis(2021-04-20) Sliepchenko, Marharyta; Kolesnyk, YanaItem Clinical polymorphism of yersiniosis in children(2020-10-20) Makarenko, Regina; Kolesnyk, YanaItem Clinical and laboratory features of infectious mononucleosis in children of early age(2020-05-08) Artyomenko, Mukola; Rudik, Natalia; Kolesnyk, Yana