Кафедра дитячих інфекційних хвороб

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    A current review of Ebola hemorrhagic fever
    (2016-05-15) Sorokina, Olga; Egwakhide, Adams; Zainab, Akanni
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    A current review of Ebola hemorrhagic fever
    (2016) Kucherenko, Olena; Egwakhide, Adams; Zainab, Akanni
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    Analysis of the effect of gene polymorphism on the course of Epstein-Barr infection
    (2017-05-24) Sorokina, Olga; Liadova, Tetiana; Kolesnyk, Yana
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    Analysis of viral hepatitis in the structure of the hepatobiliary system's diseases in children of early age
    (2020-01-20) Kolotilov, Oleksii; Tyrkin, Dmytro; Bezkrovna, Alina
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    Analysis of viral hepatitis in the structure of the hepatobiliary system`s dieseases in children of early age
    (2019-05-06) Kolotilov, Oleksii; Aleksandrovа, Kateryna; Kolesnyk, Yana
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    Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19
    (2023-08) Gavrylov, Anatoliy; Tieroshyn, Vadym; Wainstein, M.; Spyrison, Nicholas; Dai, Danyang; Ghadimi, Moji; Chávez-Iñiguez, Jonathan S.; Rizo-Topete, Lilia; Citarella, Barbara Wanjiru; Merson, Laura; Pole, Jason D.; Claure-Del, Granado Rolando; Johnson, David W.; Shrapnel, Sally
    Introduction: Acute kidney injury (AKI) has been identified as one of the most common and significant problems in hospitalized patients with COVID-19. However, studies examining the relationship between COVID-19 and AKI in low- and low-middle income countries (LLMIC) are lacking. Given that AKI is known to carry a higher mortality rate in these countries, it is important to understand differences in this population. Methods: This prospective, observational study examines the AKI incidence and characteristics of 32,210 patients with COVID-19 from 49 countries across all income levels who were admitted to an intensive care unit during their hospital stay. Results: Among patients with COVID-19 admitted to the intensive care unit, AKI incidence was highest in patients in LLMIC, followed by patients in upper-middle income countries (UMIC) and high-income countries (HIC) (53%, 38%, and 30%, respectively), whereas dialysis rates were lowest among patients with AKI from LLMIC and highest among those from HIC (27% vs. 45%). Patients with AKI in LLMIC had the largest proportion of community-acquired AKI (CA-AKI) and highest rate of in-hospital death (79% vs. 54% in HIC and 66% in UMIC). The association between AKI, being from LLMIC and in-hospital death persisted even after adjusting for disease severity. Conclusions: AKI is a particularly devastating complication of COVID-19 among patients from poorer nations where the gaps in accessibility and quality of healthcare delivery have a major impact on patient outcomes.
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    Central haemodynamic and splanchnic circulation in children with meningococcal septic shock
    (2017-05-25) Olkhovska, Olga; Korsunov, Vladimir; Georgiyants, Marine
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    Changes in immunogramme in patients with chlamydia pneumonia
    (2016-11-24) Kucherenko, Olena; Zadorozhna, Hanna; Kharun, Irina
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    Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19
    (2023-02-28) Gavrylov, Anatoliy; Tieroshyn, Vadym; Kartsonaki, C.; Baillie, J.K.; Barrio, N.G.; Zoufaly, A.; Zucman, D.; ISARIC Clinical Characterisation Group
    Background: We describe demographic features, treatments and clinical outcomes in the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) COVID-19 cohort, one of the world’s largest international, standardized data sets concerning hospitalized patients. Methods: The data set analysed includes COVID-19 patients hospitalized between January 2020 and January 2022 in 52 countries. We investigated how symptoms on admission, co-morbidities, risk factors and treatments varied by age, sex and other characteristics. We used Cox regression models to investigate associations between demographics, symptoms, co-morbidities and other factors with risk of death, admission to an intensive care unit (ICU) and invasive mechanical ventilation (IMV). Results: Data were available for 689 572 patients with laboratory-confirmed (91.1%) or clinically diagnosed (8.9%) SARS-CoV-2 infection from 52 countries. Age [adjusted hazard ratio per 10 years 1.49 (95% CI 1.48, 1.49)] and male sex [1.23 (1.21, 1.24)] were associated with a higher risk of death. Rates of admission to an ICU and use of IMV increased with age up to age 60 years then dropped. Symptoms, co-morbidities and treatments varied by age and had varied associations with clinical outcomes. The case-fatality ratio varied by country partly due to differences in the clinical characteristics of recruited patients and was on average 21.5%. Conclusions: Age was the strongest determinant of risk of death, with a 30-fold difference between the oldest and youngest groups; each of the co-morbidities included wasassociated with up to an almost 2-fold increase in risk. Smoking and obesity were also associated with a higher risk of death. The size of our international database and the standardized data collection method make this study a comprehensive international description of COVID-19 clinical features. Our findings may inform strategies that involve prioritization of patients hospitalized with COVID-19 who have a higher risk of death.
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    Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms
    (2024-05-04) Gavrylov, Anatoliy; Citarella, B.W.; Kartsonaki, C.; Ibáñez-Prada, E.D.; Zoufaly, A.; Zucman, D.
    Background: COVID-19 is primarily known as a respiratory illness; however, many patients present to hospital without respiratory symptoms. The association between non-respiratory presentations of COVID-19 and outcomes remains unclear. We investigated risk factors and clinical outcomes in patients with no respiratory symptoms (NRS) and respiratory symptoms (RS) at hospital admission. Methods: This study describes clinical features, physiological parameters, and outcomes of hospitalised COVID-19 patients, stratified by the presence or absence of respiratory symptoms at hospital admission. RS patients had one or more of: cough, shortness of breath, sore throat, runny nose or wheezing; while NRS patients did not. Results: Of 178,640 patients in the study, 86.4 % presented with RS, while 13.6 % had NRS. NRS patients were older (median age: NRS: 74 vs RS: 65) and less likely to be admitted to the ICU (NRS: 36.7 % vs RS: 37.5 %). NRS patients had a higher crude in-hospital case-fatality ratio (NRS 41.1 % vs. RS 32.0 %), but a lower risk of death after adjusting for confounders (HR 0.88 [0.83–0.93]). Conclusion: Approximately one in seven COVID-19 patients presented at hospital admission without respiratory symptoms. These patients were older, had lower ICU admission rates, and had a lower risk of in-hospital mortality after adjusting for confounders.
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    Chikenpox
    (2017-05-24) Kucherenko, Olena; Mohammad, Ahmed Mustafa Al Amayreh; Alaa, Ibrahim Mousa Alyasouri; Gaber, Daniel
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    Childhood vaccines
    (2017-05-24) Kucherenko, Olena; Ohiri, May Akuyoma
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    Chlamydia infection and respiratory disorders
    (Kharkiv National Medical University, 2014) Kuznetsov, Sergii; Kucherenko, Olena; Zharkova, Tatyana; Kucherenko, Marina
    Chlamydia infection and respiratory disorders Kuznetcov S., Kucherenko O., Zharkova T., Kucherenko M. Summery. Three chlamydial organisms are pathogenic to humans: C.pneumoniae, C.psittaci, and C.trachomatis. Clinical picture of chlamidiosis determine by species of the microbe. Efficiency of the treatment depends on timely and adequate Chlamydia infection and respiratory disorders Kuznetcov S., Kucherenko O., Zharkova T., Kucherenko M. Summery. Three chlamydial organisms are pathogenic to humans: C.pneumoniae, C.psittaci, and C.trachomatis. Clinical picture of chlamidiosis determine by species of the microbe. Efficiency of the treatment depends on timely and adequate therapy.
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    Clinical and immunological features of rotovirus infection in children infected with Epstein-Barr virus
    (2022-05) Слєпченко, Маргарита Юрівївна; Кузнєцов, Сергій Володимирович; Колесник, Яна Володимирівна; Сорокіна, Ольга Генадіївна; Sliepchenko, Marharyta; Kuznetsov, Sergey; Kolesnyk, Yana; Sorokinа, Olga
    The aim: To identify clinical and immunological features of acute rotavirus gastroenteritis occurring against the background of Epstein-Barr virus infection. Materials and methods: The study involved examination of 56 children. Of them, 33 children (1 group) did not have a background infection and 23 patients (2 group) suffered from rotavirus infection on the background of the latent form of Epstein-Barr virus infection. Children in these groups were compared by gender, age, severity of the disease and other parameters. Quantitative data were presented as mean and standard deviation (M±SD). Differences at p <0.05 were considered statistically significant. Results: The data suggest that the presence of background Epstein-Barr virus in children with rotavirus infection leads to later hospitalization, lower temperature response rates, lower frequency of vomiting at the onset of the disease, and longer duration of fever and diarrhea. At the same time, in children infected with Epstein-Barr virus, the relative content of CD8+ T lymphocytes dominated both in the acute period of the disease and in the period of convalescence against the background of reduced relative content of CD16+, CD22+ T lymphocytes and IgM in the period of early convalescence. Conclusions: The study allowed to reveal the influence of latent EBV infection on the clinical and immunological parameters of rotavirus gastroenteritis.
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    Clinical and laboratory features of infectious mononucleosis in children of early age
    (2020-05-08) Artyomenko, Mukola; Rudik, Natalia; Kolesnyk, Yana
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