Кафедра загальної та клінічної патологічної фізіології імені Д.О. Альперна
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Browsing Кафедра загальної та клінічної патологічної фізіології імені Д.О. Альперна by Subject "2024а"
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Item Determination of markers of liver damage in pregnant rats with a constant dietary intake of nutrient deficient food(2024) Kuznetsova, Milena; Bibichenko, Viktoriia; Kuznetsova, Irena; Sarapulova, SnizhanaItem Determination of the strength of the rabbits' femu bones after osteosynthesis of simulated fractures with bone plates(2024) Pavlov, Oleksiy; Pavlova, OlenaItem The effects of smoking cigarettes and electronic cigarettes on the reproductive system in conditions of military conflict(2024) Vasylieva, Sopfiia; Kuznetsova, MilenaItem Epithelial-mesenchymal transformation as a mechanism of sclerosis development in the kidneys, ureters and bladder of fetuses and newborns from mothers, whose pregnancy was complicated by iron deficiency anemia and preeclampsia(2019) Sorokina, I; Danylchenko, S; Myroshnychenko, Mykhailo; Kapustnyk, N; Lytvynenko, OA comprehensive analysis of the immunohistochemical reactions revealed the sign of epithelial-mesenchymal transformation in the kidneys, ureters and bladder of fetuses and newborns, characterized by loss of the cells epithelial phenotype and acquisition of mesenchymal phenotype, which were more pronounced in the cases of their development in conditions of maternal preeclampsia and less pronounced in maternal iron deficiency anemia, increased from the fetus to the newborn and with the maternal pathology degree of severity enlargement. Epithelial-mesenchymal transformation, which takes an active part in the development of such irreversible process as sclerosis, in the urinary system organs of fetuses and newborns, which developed in conditions of maternal preeclampsia and iron deficiency anemia, must be given due attention that in future will help to find new methods of prevention and treatment.Item Excess nutrients in the diet as a risk factor for the development of liver pathology in the mother-fetus system(2024) Kuznetsova, Milena; Bibichenko, Viktoriia; Kuznetsova, Irena; Sarapulova, SnizhanaItem Features of apoptotic and proliferative processes in experimental infected radiation-induced skin ulcer under conditions of photodynamic therapy and the use of platelet-rich plasma(2024) Pushkar, Olena; Myroshnychenko, Mykhailo; Koliada, OlehAim: The purpose of the study was to identify the features of apoptotic and proliferative processes in experimental Staphylococcus aureus-infected radiation skin ulcer under conditions of photodynamic therapy and the use of platelet-rich plasma. Materials and Methods: An experimental study was conducted on 95 six-month-old male rats of the WAG population, which were divided into three groups. Group 1 included 25 animals that were simulated a radiation ulcer of the skin in the thigh area with subsequent application to its surface on the 7th day after irradiation with 0.2 ml of a suspension of the Staphylococcus aureus (ATCC 25923) reference strain (0.5 million microbial cells/cm2 ). Group 2 included 25 animals with Staphylococcus aureus-infected radiation skin ulcer, which were subjected to photodynamic therapy a day after infection. Group 3 included 45 animals with Staphylococcus aureus-infected radiation skin ulcers, which, 1 day after infection, received photodynamic therapy in the first half of the day, and in the second half of the day the periphery of the wound defect was injected with platelet-rich plasma. The material for the study was skin with underlying soft tissues from the area of radiation exposure. Histological, immunohistochemical, morphometric and statistical methods were used. Results: In cases of simultaneous use of photodynamic therapy and platelet-rich plasma, compared with photodynamic therapy alone, the processes of apoptosis and proliferation were more balanced, active, with a shift in the proliferative-apoptotic ratio towards proliferation processes and met the needs of the regenerative process. From the 10th to the 22nd day of the experiment these processes increased, which indicated active healing processes, that, during survey microscopy on the 22nd day, were manifested by the complete filling of the wound cavity with granulation and connective tissues with the presence of an epithelial layer on the surface of the regenerate. From the 22nd to the 45th day of the experiment, a decrease in the rate of regeneration was recorded, as evidenced by a decrease in the intensity of apoptotic and proliferative processes. The intensity of the latter was sufficient, which led to the healing of Staphylococcus aureus-infected radiation skin ulcer on the 45th day with complete restoration of the original structure of the skin. Conclusions: Photodynamic therapy in combination with the use of platelet-rich plasma balancedly activates apoptotic and proliferative processes with a predominance of the latter in granulation and connective tissues filling the lumen of Staphylococcus aureus-infected radiation skin ulcer, which on the 45th day of the experiment leads to wound healing with complete restoration of the original structure of the skin.Item Morphological damage to the endocrine apparatus of the pancreas of newborn offspring as a result of prenatal exposure to hypercaloric nutrition in rat mothers(2024) Kovaltsova, Maryna; Buha, Viktoriya; Huliieva, VisalaItem Morphological damage to the endocrine apparatus of the pancreas of newborn offspring as a result of prenatal exposure to hypercaloric nutrition in rat mothers(2024) Kovaltsova, Maryna; Buha, Viktoriya; Huliieva, VisalaItem Prevelence of sedentary lifestyle among medical university students and doctors(2024) Buha, Viktoria; Hromko, Yevheniia; Huliieva, Visala; Sliusarenko, DaniloItem Role of immune function of intestinal barrier in cancer(2024) Tsinkevych, Yuliia; Kuznetsova, MilenaItem Social and economic basis of promotion of a healthy lifestyle among employees of higher medical education institutions(2024) Kuznetsova, Milena; Bibichenko, Viktoria; Shmulich, OlesiyaIn recent years, there has been a sharp decline in the population of Ukraine. That is why the promotion of measures aimed at preserving and strengthening health is gaining more and more relevance. Its implementation requires financial and social support from the state, which is extremely necessary. The purpose of this study was to establish the influence of economic and social factors on the observance of a healthy lifestyle by employees of medical education institutions and future doctors. Materials and methods. 73 respondents in the age groups of 22-24 years and 25-35 years were involved in the study, of whom 37 were 4th-6th-year students of KhNMU; 26 teachers of KhNMU and 10 teachers of V.N. Karazin KhNU. A sociological study was conducted by means of a survey. The questionnaire was distributed using Google-forms in the relevant groups in social networks Viber, Telegram and Instagram. Results. When analyzing the data of the study, the following data were obtained: the observance of a healthy lifestyle was mostly influenced by the lack of financial support, the absence of preferential conditions for the purchase of season tickets or sports equipment. In addition, it is a lack of safe places for mass sports and/or physical culture. Another factor that significantly affects the observance of a healthy lifestyle is insufficient health education, since none of the interviewees mentioned the implementation of educational activities to clarify the importance and benefits of preserving and strengthening one's health and the degree of responsibility that the individual bears. At the same time, the obtained data outline a number of issues that require resolution, firstly, it is necessary to improve the legal framework to ensure adherence to a healthy lifestyle, and secondly, to implement measures to support and promote health preservation, in particular, giving up bad habits. It is also necessary to provide funding for the creation of safe places for mass sports/physical culture and assistance in providing subscriptions and necessary sports equipment on preferential terms. Conclusion. Thus, summarizing the above information, we can conclude that the issue of maintaining a healthy lifestyle requires close attention from the state, substantiating the involvement of economic resources and society as a whole. The obtained data create a prerequisite for the development of measures to support a healthy lifestyle, in particular its promotion and clarification of the positive consequences of observing and preserving health, with mandatory visual confirmation and clear reasoning of this statement. At the same time, for the implementation of this line of activity, it is necessary to take into account the experience of the countries of the European Union, especially in improving the regulatory and legal framework.Item Special at-rich sequence-binding protein 2 and its role in healing of the experimental mandible bone tissue defect filling with a synthetic bone graft material and electrical stimulation impact(2024) Huseynov, Agil; Malanchuk, Vladislav; Myroshnychenko, Mykhailo; Kapustnyk, Nataliia; Sukharieva, Liliia; Selivanova, LarisaAim: The purpose of the study was to identify the role of SATB2 in healing of the experimental mandible bone tissue defect filling with a synthetic bone graft material and electrical stimulation impact. Materials and Methods: An experiment was carried out on 48 mature male rats of the WAG population, which were divided into 4 groups. Each group included 12 experimental animals. Group 1 included rats that were modeled with a perforated defect of the lower jaw body. Group 2 included animals that were modeled with a perforated defect similar to group 1. In animals, a microdevice for electrical action was implanted subcutaneously in the neck area on the side of the simulated bone defect. The negative electrode connected to the negative pole of the battery was in contact with the bone defect. The battery and electrode were insulated with plastic heat shrink material. Group 3 included rats that were modeled with a perforated defect similar to previous groups, the cavity of which was filled with synthetic bone graft “Biomin GT” (RAPID, Ukraine). Group 4 included animals that were modeled with a perforated defect similar to groups 1-3, the cavity of which was filled with synthetic bone graft “Biomin GT” (RAPID, Ukraine). The simulation of electrical stimulation was the same as in group 2. The material for the morphological study was a fragment of the body of the lower jaw from the zone of the perforated defect. Immunohistochemical study was performed using rabbit anti-human SATB2 monoclonal antibody. Results: In the regenerate filling the defect in the bone tissue of the lower jaw of rats, there was an increase in SATB2 expression under conditions of electrical stimulation; filling the defect with a synthetic bone graft material; simultaneous filling the defect with a synthetic bone graft material and electrical stimulation. The most pronounced expression of SATB2 was observed under conditions of simultaneous filling the defect with a synthetic bone graft material and electrical stimulation; minimally expressed – in conditions of filling the defect with a synthetic bone graft material; moderately expressed – under conditions of electrical stimulation. In the regenerate, in cases of all treatment methods, SATB2 was expressed by immune cells, fibroblastic differon cells, osteoblasts, and in case of electrical stimulation, also by adipocytes, vascular pericytes and endothelial cells, epidermis. Conclusions: The activation of SATB2 expression identified by the authors is one of the mechanisms for stimulating reparative osteogenesis under the conditions of electrical stimulation; filling the defect with a synthetic bone graft material; simultaneous filling the defect with a synthetic bone graft material and electrical stimulation. Мета: Мета дослідження – визначити роль SATB2 у загоєнні експериментального дефекту кісткової тканини нижньої щелепи, заповненому синтетичним кістковим трансплантатом та електростимуляційним впливом. Матеріали і методи: Експеримент проведено на 48 статевозрілих щурах-самцях популяції WAG, які були поділені на 4 групи. Кожна група включала 12 піддослідних тварин. До 1 групи увійшли щури, яким моделювався перфорований дефект тіла нижньої щелепи. До групи 2 увійшли тварини, яким моделювали перфораційний дефект, подібний до групи 1. Тваринам імплантували мікропристрій для електричної дії підшкірно в ділянку шиї з боку імітованого дефекту кістки. Негативний електрод, підключений до негативного полюса батареї, контактував з дефектом кістки. Акумулятор і електрод були ізольовані пластиковим термоусадковим матеріалом. 3 група включала щурів, яким моделювали перфорований дефект, подібний до попередніх груп, порожнину якого заповнювали синтетичним кістковим трансплантатом «Біомін ГТ» (РАПІД, Україна). До 4 групи увійшли тварини, яким моделювався перфорований дефект, подібний до груп 1-3, порожнину якого заповнювали синтетичним кістковим трансплантатом «Біомін ГТ» (РАПІД, Україна). Моделювання електростимуляції проводилося так само, як і в 2 групі. Матеріалом для морфологічного дослідження був фрагмент тіла нижньої щелепи із зони дірчастого дефекту. Імуногістохімічне дослідження проводили з використанням кролячих моноклональних антитіл проти людини SATB2. Результати: При заповненні регенератом дефекту кісткової тканини нижньої щелепи щурів спостерігалося підвищення експресії SATB2 в умовах електростимуляції; заповнення дефекту синтетичним кістково-трансплантаційним матеріалом; одночасне заповнення дефекту синтетичним кістковим трансплантатом і електростимуляція. Найбільш виражена експресія SATB2 спостерігалась за умов одночасного заповнення дефекту синтетичним кістковим трансплантатом та електростимуляції; мінімально виражені – в умовах заповнення дефекту синтетичним кістково-трансплантаційним матеріалом; помірно виражені – в умовах електростимуляції. У регенераті при всіх методах лікування SATB2 експресувався імунними клітинами, фібробластичними дифероновими клітинами, остеобластами, а при електричній стимуляції також адипоцитами, судинними перицитами та ендотеліальними клітинами епідермісу. Висновки: Виявлена авторами активація експресії SATB2 є одним із механізмів стимуляції репаративного остеогенезу в умовах електростимуляції; заповнення дефекту синтетичним кістково-трансплантаційним матеріалом; одночасне заповнення дефекту синтетичним кістковим трансплантатом і електростимуляція.Item Stress as a trigger factor for civilization diseases(2024) Hughes, Zlata; Kuznetsova, MilenaItem Аssessment of the effect of biodegradable implants based on polylactide on the organism animals by analysis of the dynamics of biochemical indicators of the blood at different periods of research(2024) Pavlov, Oleksiy; Pavlova, OlenaIn experimental conditions, at different times (14th, 30th, 90th, 180th, and 360th day), with the help of modern methods, the general effect on the body of rats of implants for osteosynthesis based on polylactide and calcium phosphate was investigated ceramics In comparison with the control, it was established that: the composite material, in general, does not affect the somatic status of the animals in all terms of the experiment. The content and activity of biochemical markers of the regenerative-inflammatory process (glycoproteins, chondroitin sulfates, alkaline phosphatase) in the blood serum of rats on the 30th day after implantation (composite based on polylactide) indicate an easier course of the process of restoring the injured bone, and indicators of the functional state of the liver ( ALT, AST, GHTP, bilirubin) and kidneys (creatinine, urea) after implantation in both studied groups of rats, indicates the absence of nephro- and hepatotoxicity of the implants in all periods of observation.experiment,