Browsing by Subject "2023а"

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Acute myocardial infarction in patients with type 2 diabetes mellitus
(ХНМУ, 2023-02) Blahodyr, Anhelika; Martynenko, Maksym
Acute myocardial infarction in patients with type 2 diabetes mellitus
Acute respiratory distress syndrome in trauma patients: is the risk of its development determined by the number of blood transfusions or the severity of injury, blood loss and shock?
(LLC UKRLOGOS Group, 2023-10-27) Nikonov, Vadym; Kursov, Serhii; Bitchuk, Mykolai
A blunt thoracic injury is a serious basis for the development of such a dangerous complication as acute respiratory distress syndrome (ARDS). ARDS more often formed against the background of significant blood loss, severe decompensated hemorrhagic shock against the background of trauma, as well as due to pulmonary contusion. Clinically, ARDS manifested by the development of severe acute respiratory failure. All patients necessarily need complex respiratory support. Many scientists studying this problem claim that the risk of developing ARDS increases with the number of blood transfusions. And these experts associate the number of blood transfusions with the risk of developing ARDS. The authors of the publication claim that hemotransfusions are a mandatory component of intensive therapy in a patient with massive blood loss and shock on the background of trauma, without which it is impossible to save the patient. Transfusion of blood and its components have an advantage over the use of plasma exchange solutions against the background of severe shock and lung damage. Therefore, it is incorrect to consider the number of hemotransfusion as an independent predictor of the development of ARDS. On the contrary, the severity of trauma, blood loss and shock determine the high risk of ARDS.
Acute respiratory distress syndrome in trauma patients: is the risk of its development determined by the number of blood transfusions or the severity of injury, blood loss and shock?
(2023-10) Nikonov, Vadym; Kursov, Serhii; Bitchuk, Mykolai
Adaptive mechanisms of neuroplasticity in the recovery of motor functions after ishemic stroke
(International Science Group, 2023-11-14) Riznychenko, Olena; Panasenko, Yulia; Ibrahimova, Olena; Khokhlov, Mikhail
The aim of this study was to prove the effectiveness of early physical rehabilitation for restoring motor functions in paretic limbs in patients with ischemic stroke (IS) with hemiparesis .As the results of the study showed, neglect of the physical aspect led to very unfavorable consequences: the terms of bed rest, inpatient treatment were unreasonably prolonged, leading to the formation of contractures, which leads to temporary disability of patients. Undoubtedly, early motor activation of patients contributes to a better recovery of motor functions and reduces the risk of post-stroke complications. Thus, it is better to start treatment of post-stroke spasticity as early as possible, since the shorter the period from the onset of a stroke, the greater the likelihood of improvement.
Algorithm of a differentiated approach to management of persistent pulmonary hypertension in premature infants
(Буковинський державний медичний університет, Всеукраїнська громадська організація «Асоціація неонатологів України», 2023) Клименко, Тетяна Михайлівна; Klymenko, Tetiana; Кононович, Марія Ігорівна; Konononych, Mariia
В статті наданий алгоритм диференційованого підходу до менеджменту персистуючої легеневої гіпертензії у передчасно народжених дітей, які перенесли оксидативний стрес при народженні.
Analysis of resistance of opportunistic cocci to antibiotics in infectious diseases of the lower respiratory tract
(2023) Cherkasova, Victoriia; Vovk, Oleksandra; Kovalenko, Natalia
Analysis of the epidemic situation of the COVID-19 coronavirus infection in Ukraine
(2023-04-30) Podavalenko, Alla; Malysh, Nina; Zadorozhna, Viktoriya; Zhuk, Kateryna; Zaitseva, Galina; Chorna, Inna
The epidemic process of COVID-19 in the world developed rapidly. The situation with mor bidity, despite the establishment of quarantine, the introduction of restrictive anti-epidemic measures, and vaccination, remains difficult. The results of research on the influence of meteorological factors on the dynamics of the incidence of COVID-19, hospitalization, and mortality are ambiguous and contradictory. The purpose of this study is to analyze the indicators of morbidity, hospitalization, and mortality from COVID-19 in Ukraine, and to establish the level of influence of meteorological factors on them. A high variation in morbidity, hospitalization, and mortality rates was observed in Ukraine, in 2020‒2021. A total of 3 waves of disease growth were established. The curve of hospitalization indicators of patients with COVID-19 had a correlation dependence on the incidence curve r= 0.766 (р <0.05), the maximum rates of hospitalization and mortality were registered in September–December 2021. A direct strong correlation was established between the frequency of registration of cases of COVID-19 and mortality — r= 0.899 (р <0.05). Most cases of COVID-19 were registered in the cold season, the least in June–August. Inverse correlations of moderate strength were established between the indicators of morbidity, hospitalization, and mortality and air temperature levels (–0.370< r <–0.461). Direct correlations of average strength (0.538< r <0.632) were established with the levels of relative air humidity
Analysis of the species composition and sensitivity to antibiotics of opportunistic microorganisms in bronchitis
(2023) Kovalenko, N.; Vovk, O.; Novikova, I.; Krasnikova, L.
Anatomical variability of parathyroid glands in the fetal period of human development
(Центр фінансово-економічних наукових досліджень, 2023) Lopushniak, Lesia; Honcharenko, V.; Sukhonosov, Roman
The study was conducted on 50 preparations of human fetuses without external signs of anatomical deviations or developmental anomalies using a complex of morphological research methods. The age of the subjects of the study was determined according to the consolidated tables of B.M. Patten (1959), B.P. Khvatova, Y.N. Shapovalova (1969) based on the measurement of parietal-coccygeal length (PCL). During the research, preparations of human fetuses from the museums of the Department of Human Anatomy named after M.G. Turkevich and the Department of Anatomy, Clinical Anatomy and Operative Surgery of Bukovinian State Medical University. Preparations of fetuses weighing more than 500.0 g were studied directly at the Chernivtsi Regional Communal Medical Institution «Pathological Anatomical Bureau» in accordance with the cooperation agreement.
Apelin-13 сoncentration in patients with essential hypertension, extrasystole and obesity.
(2023) Kuzminova, Nataliia; Ivankova, Anastasiya; Romanova, Valentyna; Kalitai, Volodymyr; Kulchytska, Olena; Knyazkova, Iryna
Today metabolic markers of cardiovascular risk are being actively studied. One of them is apelin-13. Objective: To assess the concentration of apelin-13 in patients with hypertension and extrasystole depending on obesity.
Application of coordination approach to change management in medical industry Agile transformation projects
(2023) Dotsenko, N.; Husieva, Y.; Chumachenko, I.; Galkin, A.; Kuchuk, H.; Padalko, H.; Bondrenko, A.
Applied problems of information systems operation
(2023) Dotsenko, Nataliia; Chumachenko, Igor; Bondarenko, Andriy; Chumachenko, Dmytro
Arterial wall condition in women with hypertension and postmenopausal osteoporosis
(2023) Kniazkova, Iryna; Bilovol, Alexander; Tsygankov, Alexander; Frolova, Tetyana; Zhadan, Andriy; Bogun, Maryna
The aim of the study was to investigate the indices of arterial stiff ness and central aortic pressure in women with hypertension in combination with osteoporosis. Design and method: The study included 68 females (mean age 62.7±3.8 years) with hypertension, grade 2 in postmenopause including 35 females with osteoporosis (group 1) and 33 females without signs of osteoporosis (group 2) ac cording to osteodensitometry investigation.
Assessment of Systematic Inflammation and Asthma Control in Asthma Patients with Elevated BMI
(2023-06) Yeryomenko, Galyna; Bezditko, Tetyana; Lawrence, DuBuske
Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19
(2023-08) Gavrylov, Anatoliy; Tieroshyn, Vadym; Wainstein, M.; Spyrison, Nicholas; Dai, Danyang; Ghadimi, Moji; Chávez-Iñiguez, Jonathan S.; Rizo-Topete, Lilia; Citarella, Barbara Wanjiru; Merson, Laura; Pole, Jason D.; Claure-Del, Granado Rolando; Johnson, David W.; Shrapnel, Sally
Introduction: Acute kidney injury (AKI) has been identified as one of the most common and significant problems in hospitalized patients with COVID-19. However, studies examining the relationship between COVID-19 and AKI in low- and low-middle income countries (LLMIC) are lacking. Given that AKI is known to carry a higher mortality rate in these countries, it is important to understand differences in this population. Methods: This prospective, observational study examines the AKI incidence and characteristics of 32,210 patients with COVID-19 from 49 countries across all income levels who were admitted to an intensive care unit during their hospital stay. Results: Among patients with COVID-19 admitted to the intensive care unit, AKI incidence was highest in patients in LLMIC, followed by patients in upper-middle income countries (UMIC) and high-income countries (HIC) (53%, 38%, and 30%, respectively), whereas dialysis rates were lowest among patients with AKI from LLMIC and highest among those from HIC (27% vs. 45%). Patients with AKI in LLMIC had the largest proportion of community-acquired AKI (CA-AKI) and highest rate of in-hospital death (79% vs. 54% in HIC and 66% in UMIC). The association between AKI, being from LLMIC and in-hospital death persisted even after adjusting for disease severity. Conclusions: AKI is a particularly devastating complication of COVID-19 among patients from poorer nations where the gaps in accessibility and quality of healthcare delivery have a major impact on patient outcomes.
Association of Myocardial Changes and Gene Expression of the NFATC1 and NFATC4—Calcineurin Signaling Pathway in Children with Bicuspid Aortic Valve /
(2023) Kamenshchyk, Andrii; Gonchar, Margaryta; Oksenych, Valentyn; Kamyshnyi, Aleksandr
Background: The role of NFATC gene expression in bicuspid aortic valve (BAV) progression is not fully understood. The aim of this study is to determine the significance of NFATC1 and NFATC4 gene expression for myocardial changes in children with BAV. Methods: In 47 children with BAV, the standard Doppler echocardiographic characteristics were detected, and the expression of the NFATC1 and NFATC4 genes was studied. Results: Posterior wall thickness in diastole (PWTd) and aortic valve peak pressure gradient (AoPPG) in BAV patients were significantly higher compared to healthy controls (PWTd median (min–max), 9 (7–10) mm vs. 7 (6–8) mm; and AoPPG median (min–max), 7.79 (2.98–15.09) mm Hg vs. 2.94 (2.42–3.72) mm Hg). The expression of the NFATC1 gene in BAV children was significantly higher compared to NFATC4 (NFATC1 median (min–max); 70.88 (8.79–106.51) e.u. vs. 7.72 (1.74–22.67) e.u., respectively p < 0.05). A significant correlation of NFATC1 expression with Ao found (R = +0.53, p < 0.05). In BAV patients with PWTd > 8 mm and Ao > 21 mm the NFATC1 expression was significantly higher compared to those with PWTd ≤ 8 mm and Ao ≤ 21 mm (NFATC1 median (min–max); 45.49 (5.01–101.52) e.u. vs. 15.53 (2.36–44.40) e.u., p < 0.05 and 81.11 (20.27–101.10) e.u. mm vs. 12.16 (2.40–45.49) e.u., p < 0.05, respectively). Conclusion: In children with BAV the high expression of the NFATC1 calcineurin signaling pathway gene is associated with elevated PWTd and Ao.
Awareness of medical students about the factors and characteristics of bacterial food poisoning
(2023-04-16) Gerasymenko, Olga; Герасименко, Ольга Ігорівна; Stelmakh, Anastasiia
Biochemical blood indicators in patients with diabetes mellitus type I and II
(sci-conf.com.ua, 2023-09-21) Marchenko, Anastasiia; Марченко, Анастасія Сергіївна; Viun, Tetiana; В'юн, Тетяна Іванівна; Vialyk, Viktoriia; Вялик, Вікторія Володимирівна; Bezsusidnia, Sofia; Безсусідня, Вікторія Володимирівна
Diabetes mellitus (DM) is a consequence of a disruption in the insulin regulation functions of a range of cells in the body. The regulation disruption can be associated with a decrease in insulin production or damage to the insulin signal transduction mechanisms. According to the World Health Organization experts’ assessment, the number of individuals with diabetes worldwide is increasing and has already become a significant medical and social issue for the populations of many countries [2]. This is characterized by the development of micro- and macrovascular complications, leading to the occurrence of heart attacks and strokes. According to the Ministry of Health (MOH) data, Ukraine has approximately 1,3 million individuals with diabetes, with the vast majority, more than 90,0%, being patients with type II diabetes.
The bioethical principles of the benefit-risk assessment of new drugs
(НФаУ, 2023-11-16) Kovalyova, Olga; Ковальова, Ольга Миколаїівна
The bioethical principles of the benefit-risk assessment of new drugs
Breast cancer relapses considering molecular biological characteristics
(Journal of medicine and life, 2023) Smolanka, Ivan; Movchan, Oleksii; Bagmut, Irina; Sheremet, Michael; Kolisnyk, Igor; Dosenko, Irina; Lyashcnko, Andriy; Ivankova, Oksana; Loboda, Anton; Shidlovsky, Oleksandr
We aimed to analyze the frequency of breast cancer relapses and their relationship with molecular and biological tumor characteristics. We studied 6,136 breast cancer patients, including 146 with relapses (Group 1) and 455 without relapses (Group 2). We divided the patients based on age, menstrual function, disease stage, histology form and grade, and molecular-biological subtype. The 5-year relapse-free rate for Group 1 was longer for Lum A and TN subtypes (60% and 40%, respectively) but shorter for Lum B and HER-2/neu-amplified subtypes (38% and 31%, respectively). Disease stage, tumor histology, and grade did not significantly affect relapse frequency in these patients. Relapses were more common in premenopausal patients and the Lum B subtype.