Breast cancer relapses considering molecular biological characteristics
Date
2023
Authors
Smolanka, Ivan
Movchan, Oleksii
Bagmut, Irina
Sheremet, Michael
Kolisnyk, Igor
Dosenko, Irina
Lyashcnko, Andriy
Ivankova, Oksana
Loboda, Anton
Shidlovsky, Oleksandr
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of medicine and life
Abstract
We aimed to analyze the frequency of breast cancer relapses and their relationship with molecular and biological tumor characteristics. We studied 6,136 breast cancer patients, including 146 with relapses (Group 1) and 455 without relapses (Group 2). We divided the patients based on age, menstrual function, disease stage, histology form and grade, and molecular-biological subtype. The 5-year relapse-free rate for Group 1 was longer for Lum A and TN subtypes (60% and 40%, respectively) but shorter for Lum B and HER-2/neu-amplified subtypes (38% and 31%, respectively). Disease stage, tumor histology, and grade did not significantly affect relapse frequency in these patients. Relapses were more common in premenopausal patients and the Lum B subtype.
Description
Keywords
breast cancer, relapse, molecular-biological properties of tumors, risk factors, 2023а
Citation
Breast cancer relapses considering molecular biological characteristics / I. I. Smolanka, O. V. Movchan, I. L. Kolisnyk [et al.] // Journal of medicine and life. ─ 2023. ─ Vol. 16, № 1. ─ P. 70─75.