Наукові праці. Кафедра загальної практики – сімейної медицини та внутрішніх хвороб
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Item Predictors of cardiovascular risk of asthma combined with obesity(2015-04) Pasiieshvili T.; Zheleznyakova N.; Tymchenko, A.Item Renin-angiotensin system: a review of historical perspectives(Івано-Франківський національний медичний університет, 2023) Kovalyova, Olga; Ковальова, Ольга Миколаїівна; Zhuravlyova, Anna; Журавльова, Анна Костянтинівна; Ivanchenko, Svitlana; Іванченко, Світлана ВолодимирівнаThe article is a review of publications concerning historical perspectives of the renin-angiotensin system. The discovery of its components is presented in chronological order, beginning with the initial identification of renin and proceeding to the subsequent discoveries of angiotensin-converting enzyme 2, angiotensin-(1-7), Mas receptor. This paper presents a modern classification of the renin-angiotensin system, dividing it into classical and non-classical branches, based on the determination of the biological effects of its components. Significant attention is devoted to elucidating the biochemical cascade of the renin-angiotensin system, its physiological transformations, and its implications in human body processes. The detrimental cardiac effects of the classical renin-angiotensin system are highlighted, along with the crucial role played by its alternative axis in counteracting the development of cardiovascular diseases. The article presents data on the involvement of angiotensin-converting enzyme 2 and its receptors in coronavirus infections, susceptibility to infection, and disease progression.