Наукові праці. Кафедра пропедевтики внутрішньої медицини № 1, основ біоетики та біобезпеки
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Browsing Наукові праці. Кафедра пропедевтики внутрішньої медицини № 1, основ біоетики та біобезпеки by Author "Ashcheulova, Tetyana"
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Item Abdominal obesity and adipokines activity in patients with arterial hypertension(2013-06) Ashcheulova, Tetyana; Ambrosova, Tetyana; Kovalyova, Olga; Saed, Abbas MudzhahidItem Adipokines dysfunction as a risk factor of type 2 diabetes mellitus in patients with hypertension(2014-06) Ashcheulova, Tetyana; Ащеулова, Тетяна Вадимівна; Ащеулова, Татьяна Вадимовна; Vizir, Marina; Ambrosova, TetyanaItem Adipokines, glucometabolic disorders, abdominal obesity in hypertensive patients(2012) Ashcheulova, Tetyana; Ambrosova, TetyanaItem Adiponectine and metabolic disorders in patients with arterial hypertension(2013-06) Ambrosova, Tetyana; Ashcheulova, Tetyana; Kovalyova, Olga; Smyrnova, VictoriiaItem Antihypertensive treatment effects on systemic inflammation, oxidative stress and proinflammatory cytokines(2020-12) Ashcheulova, Tetyana; Gerasimchuk, Nina; Kovalyova, Olga; Kompaniiets, Kira; Honchar, OleksiiHypertension in its origin is a heterogeneous and multisystemic disease. Evaluatation of the oxidative stress activity based on the level of 8-iso-PgF2α, of proinflammatory cytokines based on tumor necrosis factor-α and its type I soluble receptor and C-reactive protein is relevant for further understanding of pathogenesis of hypertension and improvement of the early diagnostics of heart failure.186 hypertensive patients have been observed during the 2-months course of treatment, aged 30 to 65 years. The serum levels of 8-iso-PgF2α (n = 34), tumor necrosis factor-α and its type I soluble receptor were determined by ELISA before and after course of treatment. C-reactive protein level was determined by biochemical method. The control group included 16 practically healthy individuals, aged 27 to 55 years. Hypertensive patients enrolled into study had been randomized into 3 arms that received different protocols of combined anti-hypertensive therapy. I clinical group – а combination of a bisoprolol and indapamid, II – а combination of a lacidipine and candesartan, III – а combination of а fosinopril sodium and hydrochlorothiazide. On the background of combined antihypertensive therapy, we observed favorable dynamics of 8-iso-PgF2α, tumor necrosis factor-α and its type I soluble receptor and C-reactive protein. Taking into account the insignificance of the correlations revealed, a one-factor dispersion analysis was applied which allows to determine with certainty the influence of the grade and duration of hypertension on the dynamics of the studied indices levels. It has been found that the grade of hypertension is related to the increase in TNF-α and 8-iso-PgF2α serum levels, but not on to TNF-α type I soluble receptor, and the duration of hypertension is related to the increase in activity of the C-reactive protein, TNF-α and its type I soluble receptor, with no relation to the level of 8-iso-PgF2α. Thus, oxidative stress possibly promotes the activation of potentially damaging immune mechanisms mediated by pro-inflammatory cytokines, nonspecific inflammation and drives the further progression of the target organs lesions.Item Beneficial effects of combined therapy with lacidipine and candesartan in obese hypertensive patients(2018-11) Ashcheulova, Tetyana; Gerasimchuk, Nina; Kovalyova, Olga; Honchar, OleksiiIntroduction Obesity is becoming one of the leading risk factors of coronary heart disease, hypertension, cerebrovascular disease. Despite the presence of a large number of antihypertensive agents and scientific substantiation of antihypertensive treatment principles it would be wrong to assume that the problem is completely solved. Development of endothelial dysfunction is one of the key pathogenic mechanisms in hypertension. This process is proven to be contributed by immune inflammation activation which is mediated by pro-inflammatory cytokines and oxidative stress. Aims: To investigate the additional benefits of the combined antihypertensive therapy with lacidipine and candesartan on the basis of studying their antioxidant properties, impact on endothelial function and pro-inflammatory cytokines activity in hypertensive patients with overweight and obesity. Methods A combination of a calcium channel blocker and angiotensin receptor blocker (lacidipine 2 mg, 4 mg, and candesartan 4mg, 8mg, 16mg) was prescribed to 30 patients with essential hypertension of grades 1-3, 30 to 65 years old (mean age – 54.7 ± 5.8 years), who previously have not been receiving regular antihypertensive therapy. Results During the course of combined antihypertensive therapy with lacidipine and candesartan, a significant reduction in i-NOS activity, TNF-α to its type I soluble receptor ratio (TNF-α/sTNF-αRI), and oxidative stress marker – 8-iso-PgF2α has been observed. Activity of e- NOS, levels of SOD and catalase, in contrast, have increased by the end of observation period. Conclusion The improvement of endothelial function due to lower level of oxidative stress and a significant decrease of immune activation has been observed in hypertensive patients with overweight and obesity under the influence of combined antihypertensive therapy with lacidipine and candesartan.Item Biomarkers of immune inflammatory activity in hypertension associated with prediabetes and diabetes mellitus 2 type(2013-06) Ashcheulova, Tetyana; Ambrosova, Tetyana; Kovalyova, Olga; Ashcheulov, Vadim; Syed, Mujheed AbbasItem Biomarkers of left ventricle remodeling in overweight patients with essential hypertension(2015-06-12) Demydenko, Ganna; Ashcheulova, Tetyana; Kovalyova, OlgaThe aim of our investigation was studying of cytokines activity in overweight patients with essential hypertension depending on peculiarities of left ventricle remodelingItem Carbohydrate and lipid disorders and adipokines levels in relation to body mass index in hypertensive patients(Revista Mexicana de Cardiología, 2018) Ashcheulova, Tetyana; Demydenko, Ganna; Ambrosova, Tetyana; Kysylenko, Kateryna; Gerasimchuk, Nina; Kochubiei, OksanaObesity is considered as a valid risk factor for cardiovascular disease, due to the fact that the risk of morbidity and mortality from various causes in obese people is signifi cantly higher. Exact mechanisms of metabolic disorders in hypertension with obesity is still discussible. The aim of the study – to determine the peculiarities of carbohydrate, lipid metabolism changes and activity of adipokines and interleukin-22, in patients with hypertension according to nutritional status. Methods: 80 patients (37 males and 43 females) with essential hypertension (EH) of average age 60.17 years were examined. Carbohydrate, lipid profi les, apolipoprotein B (apo B), tumor necrosis factor-α (TNF-α), plasminogen activator inhibitor-1 (PAI-1), adiponectin, interleukin-22 (IL-22) were estimated. Results: In patients with EH and obesity was found carbohydrates metabolism abnormalities, that was manifested as hyperinsulinemia, glucose and HbA1c levels elevation and insulin resistance (according to HOMA index). Lipid metabolism disorders were observed as valid increasing of triglycerides and apo B. Body mass index elevation was associated with progressive increasing of TNF-α and PAI-1 concentration with reducing of adiponectin level in the patients with EH. Positive relationships between TNF- and HbA1c, apo B; PAI-1 with glucose levels: negative correlation adiponectin with body mass and waist to hip ratio were detected in the patients with obesity associated (BMI ≥ 30 kg/m2) EH. Positive signifi cant correlations between apo B and insulin levels, HOMA index, and TNF-α concentration were defi ned. IL-22 in overweigh and obese patients was signifi cantly higher, correlates negatively with HDL-C. Conclusion: In patients with EH and obesity the adipokine dysfunction was revealed, that correlates with carbohydrate and lipid parameters that indicate increased proinfl ammatory and prothrombogenic processes.Item Chemerin Serum Level and Insulin Resistancein Hypertensive Patients with Obesity(2017-08-21) Kovalyova, Olga; Ashcheulova, Tetyana; Ivanchenko, Svitlana; Honchar, OleksiiThe article presents data on serum chemerin levels and its relation to insulin resistance in hypertensive patients with obesity. The results show the increase in serum chemerin levels in patients with hypertension compared healthy subjects with the highest levels in early stages of obesity that may contribute to development of insulin resistance. Advanced grades of obesity that are characterized by already established hyperinsulinemia are characterized by lower serum chemerin levels compared to grade I obesity.Item Cytokines activity and components of the renin-angiotensin system at patients with arterial hypertension and disorders of carbohydrates metabolism(2014-06) Ashcheulova, Tetyana; Ащеулова, Тетяна Вадимівна; Ащеулова, Татьяна Вадимовна; Kulikova, MariiaItem Diastolic Dysfunction: from Discovery to the Last Updates(Zaporozhye medical journal., 2019-08) Ashcheulova, Tetyana; Demydenko, Ganna; Gerasimchuk, Nina; Rezunenko, Yuri; Kochubiei, Oksana; Ambrosova, TetyanaOver a long period, chronic heart failure was primarily associated with impaired contractility of the myocardium of the left ventricular, which is a manifestation of systolic dysfunction. Based on modern ideas about the pathophysiology of CHF syndrome, systolic dysfunction is considered as one of the etiological factors along with changes in wall tension and the structure of diastolic filling, i.e. everything that is included in the concept of "LV remodeling". The objective is to present a review of the key parameters of chronic heart failure and left ventricular diastolic dysfunction according to the last updates. Material and methods. The role and significance of diastolic dysfunction as the cause of chronic heart failure syndrome, have only been started to be determined over the past three decades, which can be explained by the difficulty of early diagnostics of diastolic dysfunction. The article describes the historical evolution of estimating heart failure and left ventricular diastolic dysfunction. It is important to note the high prevalence of diastolic dysfunction. The signs of myocardial diastolic dysfunction are detected in people with almost any heart disease. The universal review of the most important parameters which determine this disorder has been presented. It has been shown that nowadays Doppler echocardiography is the noninvasive “golden standard” for estimation of diastolic dysfunction. We have presented methods of treatment for diastolic dysfunction, based on updated recommendations of the American College of Cardiology / American Heart Association in treating patients with heart failure in 2017. Conclusions. The experimental studies show that the survival rate of patients with heart failure with a preserved ejection fraction depends not so much on its indices, but on the severity of diastolic dysfunction. Diastolic dysfunction in patients with heart failure is a more prognostic mortality rate than the ejection fraction, which needs further research for better treatment.Item Dislipidemia, definition, diagnostics and treatment(2017-12) Ashcheulova, Tetyana; Gerasimchuk, Nina; Demydenko, Ganna; Kompaniiets, Kira; Kochubiei, OksanaThe review article presents the pathogenetic role of atherosclerotic vascular lesions in the development of cardiovascular diseases. The relationship between atherosclerosis and inflammation, which is characterized by the identical mechanism in the early phases, which includes the enhancement of the interaction between the vascular endothelium and circulating leukocytes is shown. The definition of such concepts as dyslipidemia, hyperlipoproteinemia and hyperlipidemia is given. The classification of hyperlipoproteinemia by Fredrickson, the clinical classification of dyslipidemia, proposed by the Ukrainian Scientific Society of Cardiologists, 2007 is considered. The correction of dyslipidemia, by both non-medicamentous measures, and drug treatment according to different variants of dyslipidemia is shown. The main groups of lipid-lowering drugs are listed. Their main mechanisms of action to reduce blood lipid levels are noted, and their side effects are listed. General recommendations are given on the monitoring of lipids and liver enzymes in patients taking lipid-lowering therapy.Item Distant apoptosis markers - FasL (CD95L) and FasR (CD95, APO-1) at hypertensive patients with prediabetes and type 2 diabetes mellitus(2013-11) Ashcheulova, Tetyana; Hussein Hamse, Moh’d Al Sheih DeepItem Distant apoptosis markers in human hypertension(2014) Ashcheulova, Tetyana; Ащеулова, Тетяна Вадимівна; Ащеулова, Татьяна Вадимовна; Kovalyova, OlgaDISTANT APOPTOSIS BIOMARKERS IN HUMAN HYPERTENSION Ashcheulova T, Kovalyova O. The aim was to study plasma apoptosis markers (TNF-α, sTNF-R1, sFasL) levels in patients with arterial hypertension (AH) depend on degree of blood pressure elevation. We examined 78 patients with AH, which were divided into 3 groups depend on AH degree: 1 group (n=18) – 1 degree AH, 2 group (n=25) – 2 degree AH, 3 group (n=35) – 3 degree AH. Plasma tumor necrosis factor-α (TNF-α), soluble TNF receptors type 1 (sTNF-R1), and soluble Fas ligand (sFasL) levels by ELISA were detected. It was found that plasma TNF-α levels in all groups patients were higher than in healthy normotensives (p<0.05). Maximum mean was detected in 2 degree AH patients. Circulating sTNF-R1 levels of all groups patients were elevated vs normal means (p<0.05). In spite of detected increasing sTNF-R1 concentration, natural TNF-α inhibitor, and insignificant decreasing of TNF-α/sTNF-R1, cytokine level remained high, that confirm possibility of TNF-mediated apoptosis pathway in hypertensive patients. Obtained results indicate possibility of Fas-related apoptosis in patients with arterial hypertension. Conclusion. Result of our clinical study showed increased immuno-inflammatory and proapoptotic activity depends on presence and degree of arterial hypertension.Item Dyslipidemia and waist to height ratio in hypertensive patients from Ukraine(ESH, 2015-06) Kochubiei, Oksana; Kovalyova, Olga; Ashcheulova, Tetyana; Кочубєй, Оксана анатоліївна; Ковальова, Ольга Миколаївна; Ащеулова, Тетяна Вадимівна; Кочубей, Оксана Анатольевна; Ковалева, Ольга Николаевна; Ащеулова, Татьяна ВадимовнаOverweight and obesity are common pathological conditions in the adult population of Ukraine and are associated with other chronic diseases, including hypertension, diabetes and dyslipidemia. All these diseases are key factors modified risk for other diseases, such as cardiovascular and renal disease. Early detection of these conditions will help in controlling their strategy. The aim of our study was to investigate the association of waist to height ratio (WHtR) in conjunction with the parameters of lipid metabolism in hypertensive patients. Methods. 73 hypertensive patients were examined. All patients underwent complex clinical examination which included estimation of complaints, history taking, physical and additional methods of examination. Following anthropometric parameters (WHtR) and parameters of lipid metabolism were measured. Data is represented as Me (Q25-Q75). Kruskal-Wallis and median test were used, р <0,05. Results. The hypertensive patients are characterized by increased levels of total cholesterol 5,67 (4,96- 7,11) mmol/L, triglyceride 2,75 (2,56-3,01) mmol/L, low-density lipoprotein-cholesterol 0,98 (0,83-1,35) mmol/L and decreased levels of highdensity lipoprotein-cholesterol 3,51 (2,77-4,54) mmol/L. Obesity was observed in 86% of hypertensive patients as measured by WHtR ≥0,5, dyslipidemia was detected in 73% patients as measured by levels of total cholesterol. In correlation analysis positive relations between WHtR and levels of total cholesterol (R=0,42; р<0,05) in hypertensive patients were found. Conclusions. The hypertension is accompanied by dyslipidemia, characterized by increased levels of total cholesterol, triglyceride, low-density lipoprotein-cholesterol and decreased levels of highdensity lipoprotein-cholesterol. Significant positive relationships between WHtR and levels of total cholesterol in hypertensive patients were detected, which is another confirmation of the clinical significance of this measurement and substantiates the need for screening patients with WHtR in determining obesity, dyslipidemia and cardiovascular risk.Item Early repolarization syndrome in modern interpretation(2019-08) Ashcheulova, Tetyana; Gerasimchuk, Nina; Sytina, IrynaRelevance of the study of early repolarization syndrome is associated with a high degree of its occurrence among the general population, namely among young people and people doing sports. Objective is to generalize the data of experimental and clinical studies which have found that the early repolarization syndrome is an idiopathic electrocardiographic phenomenon, which is considered by various specialists ambiguously; to assess the state of the cardiovascular system in the subjects, both adults and children with early repolarization syndrome, and to propose a diagnostic algorithm for detecting this phenomenon on the ECG when admitting to physical exercise and sports. The history of the development of early repolarization syndrome has been shown since 1936 to present time, which was first described by R. Shipley and W. Halleran. Clinical interest in ERS appeared as a result of a clinically established relationship with lethal arrhythmias in healthy people without structural changes in the heart. According to existing recommendations, the opinions of leading experts, including members of Heart Rhythm Society (HRS), the European Heart Rhythm Association (EHRA), the Asia-Pacific Society for Heart Rhythm (2015), it should be distinguish between the pattern and the syndrome of early ventricular repolarization. The Shanghai scale for the diagnosis of early repolarization syndrome, as well as the etiology, electrophysiology of early repolarization syndrome, its modern classification and electrocardiographic signs are presented. The features of early repolarization syndrome in athletes and in children, as well as the features of its treatment and prevention are shown. Conclusions. Thus, the early repolarization syndrome is an important cardiac problem. Future clinical and experimental studies should focus on finding out the exact causes and mechanisms for the development of the early repolarization syndrome and, ultimately, on developing strategies to prevent premature death from cardiac causes in individuals with this electrocardiogram disorder.Item Fattori di rischio per il diabete diagnosi diabete di tipo 2 nei pazienti con ipertensione(2016-02) Kochubiei, Oksana; Кочубєй, Оксана Анатоліївна; Кочубей, Оксана Анатольевна; Ashcheulova, Tetyana; Ащеулова, Тетяна Вадимівна; Ащеулова, Татьяна Вадимовна; Kovalyova, Olga; Ковальова, Ольга Миколоївна; Ковалева, Ольга Николаевна; Vizir, Marina; Візір, Марина Олександрівна; Визир, Марина АлександровнаLa revisione ha esaminato i metodi esistenti di diagnosi, quando il diabete nei pazienti con ipertensione ed i risultati di una recente ricerca in questo settore. Offerte con i dati di letteratura e analisi delle loro osservazioni, nazionali ed esteri come l'esame, che include la valutazione del metabolismo dei carboidrati, sulla base del livello di glucosio e insulina glucosio nel sangue dopo test di glucosio-tolleranza orale, hlikozilovanoho emoglobina calcolo dell'indice di insulinoresistenza - HOMA .Item Features of carbohydrate metabolism, cytokines activity and I/D gene ACE polymorphism at patients with arterial hypertension and excess weight(2015-01-17) Ashcheulova, Tetyana; Ащеулова, Тетяна Вадимівна; Ащеулова, Татьяна Вадимовна; Kulikova, MariiaItem Gender peculiarities of plasma interleukin-18 levels depend on the hypertriglyceridemic phenotype(2014-12-05) Ащеулова, Тетяна Вадимівна; Ащеулова, Татьяна Вадимовна; Ashcheulova, Tetyana; Etukudo, Ime Ime