Наукові праці. Кафедра пропедевтики внутрішньої медицини № 1, основ біоетики та біобезпеки
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Item 8-isoprostane as the main marker of oxidative stress(2018-11) Herasymchuk, NinaЦель работы – обобщение данных экспериментальных и клинических исследований, которыми установлено, что в основе ведущих метаболических процессов человека лежат окислительно-восстановительные реакции. Среди них особую роль играют свободнорадикальные реакции, ведущие к образованию перекисных соединений. Таким образом, актуально определение параметров оксидативного стресса, его интенсивности, необходимой для адекватной оценки компенсаторных возможностей организма, прогноза течения заболевания и эффективности лечения. Материалы и методы. Представлено определение понятия оксидативный стресс, перечислены важнейшие оксиданты и механизмы их повреждающего действия. Обсуждена роль оксидативного стресса в патогенезе ряда сердечно-сосуди- стых, легочных и неврологических заболеваний, а также показана активация окислительных процессов при дозревании яйцеклетки в фолликулярной жидкости. Изопростаны – недавно обнаруженная группа изомеров простагландинов. Показан метаболизм арахидоновой кислоты как наиболее широко распространенного и важного предшественника эйкозаноидовItem Abdominal obesity and adipokines activity in patients with arterial hypertension(2013-06) Ashcheulova, Tetyana; Ambrosova, Tetyana; Kovalyova, Olga; Saed, Abbas MudzhahidItem Activation of immunoinflammation in patients with comorbid condition(European Society of Hypertension, 2013-06) Kochubiei, OksanaThe aim of the research: to study the levels of inflammatory cytokin interleukin-6 in conjunction with the parameters of lipid metabolism, in patients with hypertension depend on prediabetes presence. Methods. 94 hypertensive patients were examined. Common clinical investigations were provided. Interleukin-6 plasma level detected using ELISA (BSM). Data is represented as Me (Q25-Q75). Kruskal-Wallis and median test were used, р <0,05. Results. Patients were divided into two groups depend on the presence prediabetes. The 1 group consisted of hypertensive patients without prediabetes. The 2 group included hypertensive patients with prediabetes. Hypertensive patients were characterized by increased interleukin-6 activity (18,81 (13,14-26,69) pg/ml). In hypertensive patients with prediabetes decrease interleukin-6 activity (13,94 (11,00-16,94) pg/ml) were found. The hypertension is accompanied by dyslipidemia, characterized by increased levels of total cholesterol 5,67 (4,96- 7,11) mmol/L, triglyceride 2,75 (2,56-3,01) mmol/L, low-density lipoprotein-cholesterol 0,98 (0,83-1,35) mmol/L and decreased levels of highdensity lipoprotein-cholesterol 3,51 (2,77-4,54) mmol/L, it was most expressed in patients with hypertension of the 1 group. Conclusions. According to the obtained results, interleukin-6 plasma level is increased in patients with hypertension, suggesting that the haemodynamic stress caused by elevated blood pressure is sufficient incentive to the growth secretion of these cytokines. The hypertension is accompanied by dyslipidemia, characterized by increased levels of total cholesterol, triglyceride, low-density lipoprotein-cholesterol and decreased levels of highdensity lipoprotein-cholesterol,it was most expressed in patients with hypertension of the 1 group. Significant positive relationships between interleukin-6 and parameters of lipid metabolism in patients with hypertension and prediabetes were detected.Item Activity of the main no synthesis enzymes of the combined therapy of fosinopril and hydrochlorothiazide at overweight hypertensive patients(2014-11-27) Gerasimchuk, Nina; Safargalina-Kornilova, Nadia; Potabenko, SvetlanaThe aim of the study was to investigate the activity of the main NO synthesis enzymes (endothelial-NO (e-NOS) and inducible-NO (i-NOS) synthases) at overweight patients with arterial hypertension therapy on the dynamics combined fosinopril and hydrochlorthiazide.Item Adipokine apelin activity in patients with essential hypertension and central obesity(2014-06) Demydenko, Ganna; Kovalyova, OlgaObesity has been consistently associated with hypertension and increased cardiovascular risk. BMI as a measure of obesity is a good predictor of all-cause and cardiovascular mortality, cardiovascular mortality seems to be better predicted by abdominal or central obesity in addition to BMI. Aim of the study: to investigate apelin’s activity in patients with essential hypertension with obesity according to the type of obesity.Item Adipokines activity and cardiometabolic risk factors in patients with arterial hypertension(2012) Kovalyova, Olga; Zlyvka, LarisaItem Adipokines dysfunction as a risk factor of type 2 diabetes mellitus in patients with hypertension(2014-06) Ashcheulova, Tetyana; Ащеулова, Тетяна Вадимівна; Ащеулова, Татьяна Вадимовна; Vizir, Marina; Ambrosova, TetyanaItem Adipokines, glucometabolic disorders, abdominal obesity in hypertensive patients(2012) Ashcheulova, Tetyana; Ambrosova, TetyanaItem Adiponectine and metabolic disorders in patients with arterial hypertension(2013-06) Ambrosova, Tetyana; Ashcheulova, Tetyana; Kovalyova, Olga; Smyrnova, VictoriiaItem Antihypertensive treatment effects on systemic inflammation, oxidative stress and proinflammatory cytokines(2020-12) Ashcheulova, Tetyana; Gerasimchuk, Nina; Kovalyova, Olga; Kompaniiets, Kira; Honchar, OleksiiHypertension in its origin is a heterogeneous and multisystemic disease. Evaluatation of the oxidative stress activity based on the level of 8-iso-PgF2α, of proinflammatory cytokines based on tumor necrosis factor-α and its type I soluble receptor and C-reactive protein is relevant for further understanding of pathogenesis of hypertension and improvement of the early diagnostics of heart failure.186 hypertensive patients have been observed during the 2-months course of treatment, aged 30 to 65 years. The serum levels of 8-iso-PgF2α (n = 34), tumor necrosis factor-α and its type I soluble receptor were determined by ELISA before and after course of treatment. C-reactive protein level was determined by biochemical method. The control group included 16 practically healthy individuals, aged 27 to 55 years. Hypertensive patients enrolled into study had been randomized into 3 arms that received different protocols of combined anti-hypertensive therapy. I clinical group – а combination of a bisoprolol and indapamid, II – а combination of a lacidipine and candesartan, III – а combination of а fosinopril sodium and hydrochlorothiazide. On the background of combined antihypertensive therapy, we observed favorable dynamics of 8-iso-PgF2α, tumor necrosis factor-α and its type I soluble receptor and C-reactive protein. Taking into account the insignificance of the correlations revealed, a one-factor dispersion analysis was applied which allows to determine with certainty the influence of the grade and duration of hypertension on the dynamics of the studied indices levels. It has been found that the grade of hypertension is related to the increase in TNF-α and 8-iso-PgF2α serum levels, but not on to TNF-α type I soluble receptor, and the duration of hypertension is related to the increase in activity of the C-reactive protein, TNF-α and its type I soluble receptor, with no relation to the level of 8-iso-PgF2α. Thus, oxidative stress possibly promotes the activation of potentially damaging immune mechanisms mediated by pro-inflammatory cytokines, nonspecific inflammation and drives the further progression of the target organs lesions.Item Apelin activity in patients with essential hypertension with left ventriclе remodeling(2013-06-14) Kovalyova, Olga; Demydenko, GannaApelin activity in patients with essential hypertension with left ventriclе remodelingItem Apelin and myocardial remodeling types in patients with essential hypertension(2013-06-14) Kovalyova, Olga; Demydenko, GannaApelin and myocardial remodeling types in patients with essential hypertensionItem Apelin as a marker of an insulin resistance in patients with essential hypertension(2014-05-03) Demydenko, Ganna; Kovalyova, OlgaAim of investigation was to estimate a serum level of apelin in patients (pts) with essential hypertension and insulin resistance.Item Apelin as a marker of an insulin resistance in patients with essential hypertension(2014-05-16) Demydenko, Ganna; Kovalyova, OlgaAim of investigation was to estimate a serum level of apelin in patients (pts) with essential hypertension and insulin resistance.Item Apelin as a marker of cardiac remodeling in patients with essential hypertension with left ventricle remodeling(2014-06) Demydenko, Ganna; Kovalyova, OlgaObjective: apelin 12 plays an important role in cardiovascular homeostasis. However lots of pathogenetic links remain unclear. Aim: to investigate levels of apelin-12 and nitric oxide pool in patients with essential hypertension according to left ventricular mass index (LVMI).Item Apelin as a marker of insulin resistance in patients with essential hypertension(2014-06) Demydenko, Ganna; Kovalyova, OlgaAim of investigation was to estimate a serum level of apelin in patients with essential hypertension (EH) and insulin resistance (IR).Item Apelin as a marker of prediabetes in patients with essential hypertension(2014-06) Demydenko, Ganna; Kovalyova, OlgaHyperglycemia inhibits the activity of endothelial nitric oxide synthase (eNOS) reducing the production of NO and impairing endothelium-dependent vasodilatation. Consequently, the production of reactive oxygen species – especially the superoxide anion is increased, further ingibiting the acton of eNOS. Apelin is an adipokine, novel marker of vascular outcomes in patients with chronic heart diseases. But data are still controversial.Item Apelin expression in patients with essential hypertension and prediabetes(2013-06-14) Kovalyova, Olga; Demydenko, GannaApelin expression in patients with essential hypertension and prediabetesItem Beneficial effects of combined therapy with lacidipine and candesartan in obese hypertensive patients(2018-11) Ashcheulova, Tetyana; Gerasimchuk, Nina; Kovalyova, Olga; Honchar, OleksiiIntroduction Obesity is becoming one of the leading risk factors of coronary heart disease, hypertension, cerebrovascular disease. Despite the presence of a large number of antihypertensive agents and scientific substantiation of antihypertensive treatment principles it would be wrong to assume that the problem is completely solved. Development of endothelial dysfunction is one of the key pathogenic mechanisms in hypertension. This process is proven to be contributed by immune inflammation activation which is mediated by pro-inflammatory cytokines and oxidative stress. Aims: To investigate the additional benefits of the combined antihypertensive therapy with lacidipine and candesartan on the basis of studying their antioxidant properties, impact on endothelial function and pro-inflammatory cytokines activity in hypertensive patients with overweight and obesity. Methods A combination of a calcium channel blocker and angiotensin receptor blocker (lacidipine 2 mg, 4 mg, and candesartan 4mg, 8mg, 16mg) was prescribed to 30 patients with essential hypertension of grades 1-3, 30 to 65 years old (mean age – 54.7 ± 5.8 years), who previously have not been receiving regular antihypertensive therapy. Results During the course of combined antihypertensive therapy with lacidipine and candesartan, a significant reduction in i-NOS activity, TNF-α to its type I soluble receptor ratio (TNF-α/sTNF-αRI), and oxidative stress marker – 8-iso-PgF2α has been observed. Activity of e- NOS, levels of SOD and catalase, in contrast, have increased by the end of observation period. Conclusion The improvement of endothelial function due to lower level of oxidative stress and a significant decrease of immune activation has been observed in hypertensive patients with overweight and obesity under the influence of combined antihypertensive therapy with lacidipine and candesartan.Item Bioethical issues in transplantation(2017) Pytetska, Natalia; Sultan, Fadi