Кафедра фізіології
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Browsing Кафедра фізіології by Author "Bagmut, I."
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Item The evaluations of exposure to Laprol-604 during pregnancy in wistar rats(2017) Popova, T.; Bagmut, I.; Titkova, A.; Rezunenko, Yu.; Marakushyn, DmytroThe high production volumes and widespread use of surfactants have been an environmental concern since the early 1960s. Surfactants are used in industry and agriculture and are also found in household and personal care products. The presence of surfactants and their biodegradation products in different environmental compartments can invoke a negative effect on the biota [11]. The toxicity of surfactants to living organisms has been summarized in the scientific literature. Nevertheless, some information is still lacking in relation to the reproductive effects of surfactants and interactions with hormonal system, also need to be understood in order to avoid unexpected adverse effects on future generations of people and the environment. Pregnant Wistar rats were administered 0,125; 1,25 and 12,5 mg/kg Laprol- 604 once daily by gavage from the second gestation day (GD) to the twenty first GD. Controls consisted of 20 intact pregnant Wistar rats without Laprol-604 administration. Time of parturition for each animal, number of live pups and their conditions have been examined. All of live pups were daily counted, tabulated and they have been weighed several times during postnatal period. retardation. The surviving young rats had significantly higher liver weight compared to the control animals.Item The influence of phosphorus complex organic mixtures on the content of sexual hormones and gonadotropins in the serum with violations in the reproductive system(2017-12) Zharova, A.; Bagmut, I.; Titkova, A.; Marakushyn, Dmytro; Rezunenko, Yu.At 100 Wistar rat population in subacute experiment the effect of small doses of subtoxical phosphorus detergents (Efasol, Polifos, Syntaf) on the level of sex hormones in the blood serum of females - estrogen and gonadotropins was investigated by radioimmunoassay. There were 9 research groups and one control, 10 animals in each (N=100). Estrogen and gonadotropins were studied in rat serum. Significant inhibition of gonadotropin secretion may be combined with the permeability of the haemato-encefalic barrier for phosphorus complex organic compounds and their direct influence on the hypothalamic-pituitary neuroendocrine complex.Item The state of glutathione system in rats’ liver with sodium fluoride in subtoxic doses(Oxford University Press, 2017-12) Kolisnyk, Igor; Bagmut, I.; Titkova, A.; Resunenko, Yu.; Marakushyn, DmytroOn 60 white Wistar rats' population subacute experiment was investigated to determine the effects of small doses of subtoxic chemical substance belonging to sodium fluoride liver detoxication system. There were 5 experimental groups and one control with 10 animals in each (N=60). Content glutathione reduced and enzyme activity glutathione system investigated parameters of liver homogenate of rats. Studies increase liver glutathione's content within 10 days of action at a dose of sodium fluoride 1/10 LD50 and within 30 days of the action of sodium fluoride in 1/100 LD50 dose can be considered as the activation of defense reactions, and further decrease as maladjustment organism rats. The revealed changes in the content of reduced glutathione and antioxidant enzymes activity glutathione dependent antioxidant enzymes rat liver indicate destabilization glutathione system, which may contribute to violations of adaptation in response to the development of oxidative stress as a result of fluoride intoxication.Item Usage of wobenzym in complex therapy of lyme disease(2017-12) Shepylieva, N.; Bagmut, I.; Titkova, A.; Marakushyn, Dmytro; Sulhdost, I.Duration of main clinical attributes and frequency of recurrent and chronic forms occurrence during the use of wobenzym in complex therapy were ana- lyzed in 87 patients with fixed diagnosis of Lyme disease. It was established that their duration shortened in 2,2 times (р<0,05). Accounting the data received the usage of wobenzym which potentiates the effect of antibiotics in complex therapy of Lyme dis- ease was validated.