The evaluations of exposure to Laprol-604 during pregnancy in wistar rats

Abstract

The high production volumes and widespread use of surfactants have been an environmental concern since the early 1960s. Surfactants are used in industry and agriculture and are also found in household and personal care products. The presence of surfactants and their biodegradation products in different environmental compartments can invoke a negative effect on the biota [11]. The toxicity of surfactants to living organisms has been summarized in the scientific literature. Nevertheless, some information is still lacking in relation to the reproductive effects of surfactants and interactions with hormonal system, also need to be understood in order to avoid unexpected adverse effects on future generations of people and the environment. Pregnant Wistar rats were administered 0,125; 1,25 and 12,5 mg/kg Laprol- 604 once daily by gavage from the second gestation day (GD) to the twenty first GD. Controls consisted of 20 intact pregnant Wistar rats without Laprol-604 administration. Time of parturition for each animal, number of live pups and their conditions have been examined. All of live pups were daily counted, tabulated and they have been weighed several times during postnatal period. retardation. The surviving young rats had significantly higher liver weight compared to the control animals.