The state of glutathione system in rats’ liver with sodium fluoride in subtoxic doses

Abstract

On 60 white Wistar rats' population subacute experiment was investigated to determine the effects of small doses of subtoxic chemical substance belonging to sodium fluoride liver detoxication system. There were 5 experimental groups and one control with 10 animals in each (N=60). Content glutathione reduced and enzyme activity glutathione system investigated parameters of liver homogenate of rats. Studies increase liver glutathione's content within 10 days of action at a dose of sodium fluoride 1/10 LD50 and within 30 days of the action of sodium fluoride in 1/100 LD50 dose can be considered as the activation of defense reactions, and further decrease as maladjustment organism rats. The revealed changes in the content of reduced glutathione and antioxidant enzymes activity glutathione dependent antioxidant enzymes rat liver indicate destabilization glutathione system, which may contribute to violations of adaptation in response to the development of oxidative stress as a result of fluoride intoxication.