Features of lipid metabolism disorders in patients co-infected with HIV/HCV

Abstract

The content of lipid metabolism was determined in 107 patients: with chronic hepatitis C - 36 patients, with HIV infection - 35 and co-infection of HIV/HCV – 36 patients. In the investigated patients lipid metabolism disorders were identified such as an increase of the triglycerides, low density lipoprotein, very low density lipoprotein and a reduction of high density lipoprotein contents. Significantly higher levels of triglycerides (p<0.001) was observed in patients co-infected with HIV/HCV compared with patients with chronic hepatitis C and HIV-infection.Systematic data analysis suggests that in patients co-infected with HIV/HCV established a strong direct relationship between the level of CD4+ cells and the degree of increase in triglycerides (r=0,64, p<0.001), atherogenic coefficient (r=0,57, p<0.001).