Наукові праці. Кафедра інфекційних хвороб
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Item Історія кафедри інфекційних хвороб харківського національного медичного університету в подіях і персоналіях. Погляд крізь століття(2023-11-21) Капустник, Валерій Андрійович; Юрко, Катерина Володимирівна; Козько, Володимир Миколайович; Градиль, Григорій Іванович; Меркулова, Ніна Федірівна; Ткаченко, Віталій Григорович; Соломенник, Ганна Олегівна; Могилинець, Олена ІванівнаВисвітлено основні події та персоналії в історії кафедри інфекційних хвороб Харківського національного медичного університету за 100 років її існування.Item Діагностична перспективність оцінки вірулентного потенціалу штамів Blastocystis sp. за показниками рівнів утворення амебоїдних форм та протеазної активності(2022) Похил, С.І.; Тимченко, О.М.; Бодня, Ігор ПавловичItem Distribution and frequency of Blastocystis sp. by methods of microscopy and cultivation in faeces of residents of Kharkov region(2022-07) Bodnia, I.; Pokhil, S.; Bodnia, K.; Pavliy, V.; Skoryk, L.Item Symptom‐based case definitions for COVID‐19: Time and geographical variations for detection at hospital admission among 260,000 patients(2022-08-07) Gavrylov, Anatoliy; Tieroshyn, VadymIntroduction: Case definitions are used to guide clinical practice, surveillance and research protocols. However, how they identify COVID-19-hospitalised patients is not fully understood. We analysed the proportion of hospitalised patients with laboratory-confirmed COVID-19, in the ISARIC prospective cohort study database, meeting widely used case definitions. Methods: Patients were assessed using the Centers for Disease Control (CDC), European Centre for Disease Prevention and Control (ECDC), World Health Organization (WHO) and UK Health Security Agency (UKHSA) case definitions by age, region and time. Case fatality ratios (CFRs) and symptoms of those who did and who did not meet the case definitions were evaluated. Patients with incomplete data and non-laboratory-confirmed test result were excluded. Results: A total of 263,218 of the patients (42%) in the ISARIC database were included. Most patients (90.4%) were from Europe and Central Asia. The proportions of patients meeting the case definitions were 56.8% (WHO), 74.4% (UKHSA), 81.6% (ECDC) and 82.3% (CDC). For each case definition, patients at the extremes of age distribution met the criteria less frequently than those aged 30 to 70 years; geographical and time variations were also observed. Estimated CFRs were similar for the patients who met the case definitions. However, when more patients did not meet the case definition, the CFR increased. Conclusions: The performance of case definitions might be different in different regions and may change over time. Similarly concerning is the fact that older patients often did not meet case definitions, risking delayed medical care. Whileepidemiologists must balance their analytics with field applicability, ongoing revision of case definitions is necessary to improve patient care through early diagnosis and limit potential nosocomial spread.Item ISARIC-COVID-19 dataset: a prospective, standardized, global dataset of patients hospitalized with COVID-19(2022) Gavrylov, Anatoliy; Tieroshyn, VadymThe International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 dataset is one of the largest international databases of prospectively collected clinical data on people hospitalized with COVID-19. This dataset was compiled during the COVID-19 pandemic by a network of hospitals that collect data using the ISARIC-World Health Organization Clinical Characterization Protocol and data tools. The database includes data from more than 705,000 patients, collected in more than 60 countries and 1,500 centres worldwide. Patient data are available from acute hospital admissions with COVID-19 and outpatient follow-ups. The data include signs and symptoms, pre-existing comorbidities, vital signs, chronic and acute treatments, complications, dates of hospitalization and discharge, mortality, viral strains, vaccination status, and other data. Here, we present the dataset characteristics, explain its architecture and how to gain access, and provide tools to facilitate its use.Item Стан клітинних автоімунних реакцій у хворих на хронічний гепатит С(2022-05-10) Юрко, Катерина Володимирівна; Соломенник, Ганна ОлегівнаItem Аналіз частоти поствакцинальних реакцій після вакцинації від нової коронавірусної хвороби(2022-04-19) Юрко, Катерина Володимирівна; Соломенник, Ганна Олегівна; Пелих, Іван миколайович; Винокурова, Ольга МиколаївнаItem Застосування сучасних інформаційних технологій як інструменту моніторингу якості медичної освіти(2022-08-02) Юрко, Катерина Володимирівна; Меркулова, Ніна Федорівна; Соломенник, Ганна Олегівна; Могиленець, Олена ІванівнаItem Ретроспективний аналіз частоти ураження органу зору в пацієнтів з новою коронавірусною хворобою за даними анонімного он-лайн анкетування(2022-10-21) Юрко, Катерина Володимирівна; Соломенник, Ганна Олегівна; Винокурова, Ольга Миколаївна; Сич, Діана ОлександрівнаItem Порушення з боку нервової системи як наслідок перенесеної COVID-19 в осіб молодого віку(2022-11-09) Юрко, Катерина Володимирівна; Соломенник, Ганна Олегівна; Винокурова, Ольга Миколаївна; Коваленко, Анастасія Олександрівна; Базилєва, Юлія ГеннадіївнаItem Аналіз обізнаності щодо вакцинації проти сезонного грипу серед мешканців міста Харків залежно від віку респондентів(2022-10-16) Cоломенник, Ганна Олегівна; Винокурова, Ольга Миколаївна; Федоренко, Ольга ВалентинівнаItem Погляди на значення імуногенетичних факторів у патогенезі HCV-інфекції в історичному аспекті(2022) Юрко, Катерина; Соломенник, ГаннаItem Аналіз прихильності студентів навчального закладу вищої медичної освіти до вакцинації проти нової коронавірусної хвороби, спричиненої штамом Дельта(2022-04-26) Юрко, Катерина Володимирівна; Соломенник, Ганна Олегівна; Кравченко, Вікторія Олександрівна; Винокурова, Ольга МиколаївнаItem Dynamics analiysis of the measles incindence rate among the population of Ukraine in the period from 2015 to 2021(2022-06-10) Yurko, Kateryna; Solomennyk, Hanna; Vynokurova, Olha; Chebotenko, O.; Hladchenko, N.Item The value of open-source clinical science in pandemic response: lessons from ISARIC(2021-12) Gavrylov, A.; Tieroshyn, V.; Abbas, A.; Abdukahil, S.; Abdulkadir, N.The article presents an ISARIC international cohort analysis that describes demographic and clinical characteristics, as well as associations with outcomes, in a large international cohort of hospitalized patients.Item Особливості реалізації «перевернутого навчання» на етапі післядипломної медичної освіти(2021-05) Юрко, Катерина Володимирівна; Бондаренко, Андрій Володимирович; Тєрьошин, Вадим Олександрович; Сохань, Антон Васильович; Меркулова, Ніна Федорівна; Солоиенник, Ганна Олегівна; Могиленець, Олена Іванівна; Граділь, Григорій Іванович; Кацапов, Дмитро Володимирович; Бондар, Олександр Євгенійовия; Гаврилов, Анатолій Вікторович; Винокурова, Ольга Миколаївна; Ткаченко, Віталій ГригоровичItem Современный подход к проведению генотеста у больных хроническим гепатитом С(2021-03) Юрко, Екатерина Владимировна; Соломенник, Анна ОлеговнаItem Місце гепатопротекторів у лікуванні хронічних вірусних гепатитів на сучасному етапі(Scientific Publishing Center, 2021-05) Юрко, Катерина Володимирівна; Соломенник, Ганна ОлегівнаУ статті розглянуто питання застосування гепатопротекторів у комплексному лікуванні хворих на хронічні вірусні гепатити на сучасному етапі. Наведено їхню класифікацію, механізм дії та характер впливу на різні ланки патологічного процесу в печінці. Під час вибору препарату запропоновано враховувати стан показників ліпідного обміну.Item Assessment of the demyelinating process activity in patients with herpesviral meningitis and meningoencephalitis based on the level of myelin basic protein (MBP) in the cerebrospinal fluid(Aluna Publishing, 2021-03) Sokhan, Anton; Burma, Yaroslava; Pavlov2, Volodimir; Goidenko, Oleksandr; Markush, Larisa; Spitsyna, Hanna; Kolesnyk, LiudmylaThe aim: To study the peculiarities of demyelination by detection of changes in the levels of myelin basic protein (MBP) in CSF of patients with acute herpesviral meningitis (M) and meningoencephalitis (ME). Materials and methods: A total of 136 CSF samples from 68 patients with herpesviral M and ME were collected. The control group consisted of patients with acute respiratory infection and meningismus. MBP level in CSF was identified at the admission and after 10-12 days of treatment. Analysis of MBP concentrations in CSF was performed using an enzyme immunoassay. Results: Examination of patients on the first day of hospitalization showed the presence of a significant increase of MBP in the CSF in all patients with viral M/ME compared with the indicators of the comparison group (р<0.01). In all groups of patients with ME, the level of MBP in CSF was significantly higher than the indicators of comparison group and M groups of the suitable etiology of the disease (p<0.01). In patients with lethal outcome, the MBP level was significantly higher (p<0.01) than in all meningitis groups, but we did not find a significant difference with the patients with ME (p>0.05). Conclusions: The increase of MBP level identified in patients with acute M/ME confirms the presence of the demyelinating process that occurs in all patients, but it is more pronounced in patients with ME.Item Morphological efficacy evaluation of gel with carbon dioxide extract of hops in case of complicated wound infection acne vulgaris(Aluna Publishing, 2021-01) Moiseienko, Tetiana; Torianyk, Inna; Khrystian, Gennadiy; Rybak, Viktoria; Voronkina, Iryna; Melnyk, Anatoliy; Merkulova, Nina; Mohylenets, Olena; Solomennyk, Ganna; Popova, Natalia; Ivannik, Victoria; Myroshnychenko, MykhailoThe aim of the study is to reveal in the experiment the morphological features of the infected skin wounds healing, which are a manifestation of acne vulgaris severe and very severe forms, using a gel with carbon dioxide extract of hops. Materials and methods: An experimental study was carried out on 80 male WAG rats of three months of age. The animals were divided into 9 groups. Group 1 consisted of intact animals ( n = 6 ) . Group 2 was represented by animals ( n = 6 ) , which had hair epilation on the dorsal surface of the body in an area of 1 cm2, followed by application of 2 ml of placebo gel to this area. Group 3 included animals ( n = 6 ) , which were epilated on the dorsal surface of the body in an area of 1 cm2 and applied 2 ml of 1 % gel with carbon dioxide extract of hops. Group 4 included rats ( n = 6 ) , which were epilated on the dorsal surface of the body in an area of 1 cm2 and simulated thermal damage. Group 5 was represented by 10 rats, who were epilated on the dorsal surface of the body in an area of 1 cm2, simulated thermal damage, followed by applying 2 ml of placebo gel to the wound surface. Group 6 included rats ( n = 1 0 ) , who underwent measures similar to group 5, followed by application of 2 ml of 1 % gel with carbon dioxide extract of hops to the wound surface. In group 7, there were 6 rats, which were epilated on the dorsal surface of the body in an area of 1 cm2, thermal damage to the skin with underlying soft tissues was simulated, followed by application to the wound surface the reference strainsof Staphylococcus aureus, Streptococcus pyogenes, Proteus vulgaris, Propionibacterium acnes, Escherichia coli, Pseudomonas aeruginosa, Malassezia slooffiae, Malasseziapachydermatis, Candida albicans, Candidaparapsilosis. In groups 8 and 9, there were 15 rats each, which underwent measures similar to group 7, followed by applying 2 ml of placebo gel on its surface on the next day after infection of the wound in group 8, and in group 9 - 2 ml of 1 % gel with carbon dioxide extract hops. The material for the study was the skin with underlying soft tissues. It was used histological, histochemical, morphometric and statistical methods. Results: This experimentally created gel with carbon dioxide extract of hops activates separation processes of horny masses from the surface of the epidermis, cleaning the pores of the skin; stimulating the proliferative activity of the epidermis, which is located in the marginal sections of the wound or covers the surface of the regenerate; activating the processes of cleansing the wound from necrotic tissue; activating the growth and maturation of granulation tissue with its subsequent transformation into connective tissue. It has antiinflammatory, bactericidal and antimycotic effects, normalizing skin microbiocenosis. Conclusions: The complex morphological study has showed that gel with carbon dioxide extract of hops is a highly effective drug in treatment of severe and very severe acne vulgaris, characterized by the development of deep and infected wound defects.