Кафедра інфекційних хвороб

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    Історія кафедри інфекційних хвороб харківського національного медичного університету в подіях і персоналіях. Погляд крізь століття
    (2023-11-21) Капустник, Валерій Андрійович; Юрко, Катерина Володимирівна; Козько, Володимир Миколайович; Градиль, Григорій Іванович; Меркулова, Ніна Федірівна; Ткаченко, Віталій Григорович; Соломенник, Ганна Олегівна; Могилинець, Олена Іванівна
    Висвітлено основні події та персоналії в історії кафедри інфекційних хвороб Харківського національного медичного університету за 100 років її існування.
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    External Respiratory Function, Inflammation Markers, and Life Quality Depending on the Volume of Tuberculosis Lung Lesion
    (2023) Shevchenko, Olga; Todoriko, Lilia; Matvyeyeva, Svitlana; Ovcharenko, Irina; Shvets, Olga; Pohorielova, Olha
    Tuberculosis is a common disease in many countries, so understanding of its impact on life quality and respiratory function as well as study of correlations of these parameters with biochemical markers of tuberculosis course and treatment effectiveness is important in evaluating new methods of treatment and prevention. Objective — to investigate the relationships between the function of external respiration, the level of Humanbeta-defensin-1, ferritin, interleukin-6, quality of life and the volume of tuberculosis lung lesions. Materials and methods. 100 patients with pulmonary tuberculosis were included in the study. Patients were divided into groups depending on the volume of tuberculous lesions: Group 1 (n = 36) had lesions within one lung, Group 2 (n = 64) had lesions of both lungs. Examination of patients was carried out according to the current standards of providing medical care to tuberculosis patients. In addition, patients underwent determination of ferritin, interleukin-6 (IL-6), and Human-beta-defensin-1 (HBD-1) levels in the blood by ELISA test. Spirography was performed to determine the parameters of the function of external breathing. Interviews were provided using SF-36 questionnaire with the determination of the main indicators of quality of life. Statistical data processing was carried out using the Statistica 8.0. Results and discussion. Comparison of spirometry parameters between groups showed significantly lower respiratory function parameters in patients with bilateral tuberculous lesions compared to patients with unilateral lesions. A decrease in external respiratory function indicators was accompanied by a corresponding significant decrease in the quality of life, which was more pronounced in Group 2. The described changes occurred against the background of a significant increase in the studied biochemical markers in Group 2 compared to Group 1. Thus, the level of HBD-1 in Group 1 was (8.11 ± 1.78) pg/ml, in Group 2 it was (30.14 ± 3.89) pg/ml (p < 0.05). Ferritin level in Group 1 was (94.19 ± 1.18) ng/ml, in Group 2 — (113.45 ± 4.77) ng/ml (p < 0.05). The level of IL-6 in Group 1 was (81.43 ± 1.14) pg/ml, in Group 2 — (103.34 ± 3.46) pg/ml (p < 0.05). When investigating the correlations between the levels of HBD-1, ferritin, IL-6 and quality of life indicators according to the SF-36 scale, reliable inverse relationships were found between all quality of life parameters and the levels of HBD-1 and ferritin. When investigating the correlations between the levels of HBD-1, ferritin, IL-6 and parameters of the function of external respiration, it was found that HBD-1 demonstrates negative reliable correlations with both volume and speed indicators (– 0.24…– 0.32). IL-6 shows negative relationships only in FVC (rs = – 0.42) and FEV1 (rs = – 0.41), however, these correlations are stronger compared to HBD-1. Conclusions. An increase in the volume of tuberculous lesions of the lungs leads to a more pronounced violation of the function of external breathing and, as a result, a decrease in the patients life quality. The described changes are accompanied by an increase in the levels of HBD-1, ferritin and IL-6, which makes the studied biomarkers promising predictors of deterioration of external respiratory function and quality of life. HBD-1 and ferritin demonstrated more pronounced correlations with parameters of life quality. The investigated markers have negative correlations with indicators of both restrictive and obstructive ventilation disorders.
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    Symptom‐based case definitions for COVID‐19: Time and geographical variations for detection at hospital admission among 260,000 patients
    (2022-08-07) Gavrylov, Anatoliy; Tieroshyn, Vadym
    Introduction: Case definitions are used to guide clinical practice, surveillance and research protocols. However, how they identify COVID-19-hospitalised patients is not fully understood. We analysed the proportion of hospitalised patients with laboratory-confirmed COVID-19, in the ISARIC prospective cohort study database, meeting widely used case definitions. Methods: Patients were assessed using the Centers for Disease Control (CDC), European Centre for Disease Prevention and Control (ECDC), World Health Organization (WHO) and UK Health Security Agency (UKHSA) case definitions by age, region and time. Case fatality ratios (CFRs) and symptoms of those who did and who did not meet the case definitions were evaluated. Patients with incomplete data and non-laboratory-confirmed test result were excluded. Results: A total of 263,218 of the patients (42%) in the ISARIC database were included. Most patients (90.4%) were from Europe and Central Asia. The proportions of patients meeting the case definitions were 56.8% (WHO), 74.4% (UKHSA), 81.6% (ECDC) and 82.3% (CDC). For each case definition, patients at the extremes of age distribution met the criteria less frequently than those aged 30 to 70 years; geographical and time variations were also observed. Estimated CFRs were similar for the patients who met the case definitions. However, when more patients did not meet the case definition, the CFR increased. Conclusions: The performance of case definitions might be different in different regions and may change over time. Similarly concerning is the fact that older patients often did not meet case definitions, risking delayed medical care. Whileepidemiologists must balance their analytics with field applicability, ongoing revision of case definitions is necessary to improve patient care through early diagnosis and limit potential nosocomial spread.
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    ISARIC-COVID-19 dataset: a prospective, standardized, global dataset of patients hospitalized with COVID-19
    (2022) Gavrylov, Anatoliy; Tieroshyn, Vadym
    The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 dataset is one of the largest international databases of prospectively collected clinical data on people hospitalized with COVID-19. This dataset was compiled during the COVID-19 pandemic by a network of hospitals that collect data using the ISARIC-World Health Organization Clinical Characterization Protocol and data tools. The database includes data from more than 705,000 patients, collected in more than 60 countries and 1,500 centres worldwide. Patient data are available from acute hospital admissions with COVID-19 and outpatient follow-ups. The data include signs and symptoms, pre-existing comorbidities, vital signs, chronic and acute treatments, complications, dates of hospitalization and discharge, mortality, viral strains, vaccination status, and other data. Here, we present the dataset characteristics, explain its architecture and how to gain access, and provide tools to facilitate its use.
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    Стан клітинних автоімунних реакцій у хворих на хронічний гепатит С
    (2022-05-10) Юрко, Катерина Володимирівна; Соломенник, Ганна Олегівна
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    Аналіз частоти поствакцинальних реакцій після вакцинації від нової коронавірусної хвороби
    (2022-04-19) Юрко, Катерина Володимирівна; Соломенник, Ганна Олегівна; Пелих, Іван миколайович; Винокурова, Ольга Миколаївна
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    Застосування сучасних інформаційних технологій як інструменту моніторингу якості медичної освіти
    (2022-08-02) Юрко, Катерина Володимирівна; Меркулова, Ніна Федорівна; Соломенник, Ганна Олегівна; Могиленець, Олена Іванівна
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    Ретроспективний аналіз частоти ураження органу зору в пацієнтів з новою коронавірусною хворобою за даними анонімного он-лайн анкетування
    (2022-10-21) Юрко, Катерина Володимирівна; Соломенник, Ганна Олегівна; Винокурова, Ольга Миколаївна; Сич, Діана Олександрівна