Кафедра інфекційних хвороб
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Item A lethal case of viral-bacterial pneumonia with relative lymphopenia: retrospective evaluation(Харківський національний медичний університет, 2019) Gradil, GrigoryThe author presents a clinical case of a fatal course of community acquired viral-bacterial pneumonia in a patient without underlying risk factors but with atypical course. Lymphopenia and neutropenia development is considered a prognostic factor for severe course and the probability of a fatal outcome. Morphology demonstrated impairment of vascular endothelial cells, hypoplasia of the lymphoid follicles in the spleen, massive necrosis of the liver parenchyma with hemorrhages. At present such case should be differentiated with pneumonia caused by mycoplasmas, legionella, rickettsias, chlamydia, pneumocystis, as well as, in the presence of epidemiological data, with influenza A (H1N1) California 2009, influenza H5N1, coronaviral infection (MERS-CoV), that is infections complicated with acute respiratory distress syndrome (ARDS). The mechanisms of neutropenia and lymphopenia development in viral lesions of the respiratory system require further inverstigation.Item Acute appendicitis on background of antiviral therapy of chronic hepatitis C(Kharkiv National Medical University, 2013-05-16) Lisanec, K.; Kopylov, N.; Bondar, O.Item Acute intestinal infections(2007) Kozko, Volodymyr; Bondarenko, A.; Gradil, G.; Katsapov, D.; Krasnov, M.; Nikitina N.Острые кишечные инфекции: учебник для иностранных студентов медицинских вузовItem Acute respiratoryinfections(2009) Kozko, Volodymyr; Bondarenko, A.; Katsapov, Dmytro; Krasnov, M.; Gradil, G.; Nikitina, N.; Kopeychenko J.Острые респираторные инфекции: учебное пособие для иностранных студентов медицинских вузовItem Analysis clinical data, clinical status values key proinflammatory cytokine IL-1β and leukocyte index of intoxication in the initial period of influenza and other respiratory(2015-05-15) Tertyshnyy, V.; Berezhna, A.; Bibik, V.; Iemets, T.Item Analysis of clinical and laboratory parameters and efficiency of treatment of acute purulent meningitis in Kharkov's(2014-05) Pavlova, O.; Sokhan, A.Item Analysis of clinical and laboratory parameters and efficiently of treatment of acute purulent meningitis in Kharkov’s regional clinical hospital of infectious diseases in 2011–2013(2014) Sokhan, A.; Pavlova, O.; Isaeva, A.; Zoc, Y.; Kalugniy, V.; Solomennik, A.; Goydenko, A.; Markush, Larisa; Pavlov, V.; Kononenko, A.; Gavrylov, AnatoliyItem Analysis of T-cell immunity in patients co-infected with HIV/HCV(2015-03-30) Kozko, Volodymyr; Iurko, Kateryna; Solomennik, G.; Adeiami, A.Item Anaplasmosis: experimental immunodeficient state model(2019) Bondarenko, Andriy; Pokhil, Sergey; Lytvynenko, Marianna; Bocharova, Tetiana; Gargin, VitaliyIntroduction: The recently described anaplasmosis infection is widespread but concerns to the insufficiently known group of diseases. The aim of our research is the development of uniform biological model for reproducing of artificial immunodeficient state by experimental anaplasmosis. Materials and methods: Algorithm of experimental anaplasmosis reproducing, consisted of such consecutive stages: 1) artificial forming of the immunodeficient state at nonlinear white mise (Mus musculus L.); 2) preparation of the tested biological material samples; 3) inoculation by prepared samples of the laboratory animals with the artificially formed immunodeficient state; 4) sampling from the dead or slaughtered (by the method of chloroformed anesthesia) experimental animals of sectional material (organs and targets tissues); 5) verification of aetiology by express detection of causative agents by the method of PCR in the selected samples of sectional material. Results: Biological model of experimental anaplasmosis have been created suitable for realization of both diagnostic and epidemiological, epizootic, ecobiological and other researches of different origin biological material samples, including samples of solid and liquid consistency material. Formed model realised in premature death of experimental animals in 17.4 % cases; resulted in an onset of disease clinical signs without death during the term of supervision in 43.8 % cases; coursed in the absence of the expressed symptoms of infection in 31.3 % cases. Conclusions: Developed biological model of experimental anaplasmosis consists in that as laboratory animals with the increased sensitiveness to the infection and accumulation of causative agent are used white nonlinear mice with the artificially formed immunodeficient state.Item Application of apri index for noninvasive evalution of liver fibrosis activity in patients with chronic hepatitis C(2018-04-24) Kozko, Volodymyr; Vinokurova, O.; Baichykova, A.; Pavlova, A.seventy-nine patients, age from forty to forty-five years old, with chronic hepatitis C were examined in the clinic. All the patients studied determined the stage o f fibrosis and the severity o f the disease with the help o f the GenoFibroTest system, an expert system o f biochemical blood indices. Modern statistical methods were used to determine the dependence between the stages o f fibrosis and APRI. It was found that the APRI value from 0 to 1 corresponds to F0 - F1, more than 1 to F2-F4, respectively.Item Assessment of the demyelinating process activity in patients with herpesviral meningitis and meningoencephalitis based on the level of myelin basic protein (MBP) in the cerebrospinal fluid(Aluna Publishing, 2021-03) Sokhan, Anton; Burma, Yaroslava; Pavlov2, Volodimir; Goidenko, Oleksandr; Markush, Larisa; Spitsyna, Hanna; Kolesnyk, LiudmylaThe aim: To study the peculiarities of demyelination by detection of changes in the levels of myelin basic protein (MBP) in CSF of patients with acute herpesviral meningitis (M) and meningoencephalitis (ME). Materials and methods: A total of 136 CSF samples from 68 patients with herpesviral M and ME were collected. The control group consisted of patients with acute respiratory infection and meningismus. MBP level in CSF was identified at the admission and after 10-12 days of treatment. Analysis of MBP concentrations in CSF was performed using an enzyme immunoassay. Results: Examination of patients on the first day of hospitalization showed the presence of a significant increase of MBP in the CSF in all patients with viral M/ME compared with the indicators of the comparison group (р<0.01). In all groups of patients with ME, the level of MBP in CSF was significantly higher than the indicators of comparison group and M groups of the suitable etiology of the disease (p<0.01). In patients with lethal outcome, the MBP level was significantly higher (p<0.01) than in all meningitis groups, but we did not find a significant difference with the patients with ME (p>0.05). Conclusions: The increase of MBP level identified in patients with acute M/ME confirms the presence of the demyelinating process that occurs in all patients, but it is more pronounced in patients with ME.Item Bartonellosis: epidemiology aspects among HIV- infected(2013-10-03) Bondarenko, A.; Katsapov, DmytroItem Biochemical manifestations of liver affection in patients with infectious mononucleosis(2014-03) Mohylenets, Olena; Kozko, Volodymyr; Merkulova, Nina; Bondarenko, A.; Solomennik, G.; Iurko, Kateryna; Nikitina, V.; Vinokurova, O.Item Biochemical parameters of cerebrospinal fluid in patients with acute viralmeningitis and meningoencephalitis(2018) Kozko, Volodymyr; Sokhan, A.; Burma, Ya.; Kuznetsova, Anastasiia; Gavrylov, AnatoliyThe aim. Determination of the diagnostic value of lactate, lactate dehydrogenase, cholinesterase, acid phosphatase and cholinesterase in CSF for early diagnosis and prognosis of acute viral meningitis and meningoencephalitis. Materials and methods. 92 patients with a confirmed viral etiology of the disease were examined. Among them – 20 patients with HSV 1,2 neuroinfection, 19 patients with EBV, 15 with VZV, 14 with HHV-6 and 24 patients with enterovirus neuroinfection. Patients were divided into groups depending on the etiology and severity of the disease. In addition to analyzing the clinical course of the disease, we conducted a CSF study to determine the level of lactate, lactate dehydrogenase, creatinine kinase, cholinesterase and acid phosphatase on admission to hospital and after 10-12 days of treatment. Results of the study. The highest mean age was observed in patients with VZV meningitis – 38.27±18.24 years, the youngest were patients with enterovirus infection – 24.05±5.72 (р˂0.001). The number of women and men was the same in almost all groups, but among patients with HSV 1, 2 neuroinfection women were significantly prevalent – 16 (80 %) out of 20 cases. The most severe course was observed in groups of EBV and HHV-6 neuroinfections. Neuroinfections of enterovirus etiology had the most favorable course. The obtained data indicate the dependence of the levels of indicators, which were determined primarily from the severity of the disease. So the level of creatinine kinase and acid phosphatase in patients with moderate severity was significantly higher in comparison with severe patients (p<0.05). The lactate level was higher in patients with severe neuroinfection (p<0.05). The highest levels of lactate were detected in patients with HHV-6 meningoencephalitis (p<0.05). The level of cholinesterase was significantly lower in severe patients. Conclusions. The obtained data confirm the presence of deep metabolic disturbances in the brain tissues in all patients with acute viral neuroinfections both at the onset of the disease and in the dynamics of treatment. Determination of levels of creatinine kinase, acid phosphatase, lactate and cholinesterase in CSF of patients with acute viral neuroinfection has a high diagnostic value, but cannot be used to predict an unfavorable course of the diseaseItem Biogenic amines in patients with acute hepatitis B(2014) Vinokurova, O.; Mohylenets, Olena; Dulembova, V.; Onoprienko, E.Item Catarrhal-respiratory syndrome in clinic of infectious diseases(2013-02-19) Bondarenko, A.Item Cerebral toxoplasmosis in HIV-infected persons(2015-01-20) Gavrylov, Anatoliy; Sokhan, A.; Zots, Ya.; Hvozdetska, M.; Berezhnoy, B.Item Cerebrospinal fluid levels ofneurospecific markers in adult patients with bacterial meningitis(Тбилисский государственный медицинский университет, 2017) Sokhan, A.; Zots, Y.; Gavrylov, Anatoliy; Iurko, Kateryna; Solomennik, A.; Kuznetsova, AnastasiiaAt present, the great attention is given to the neurospecific markers as their elevated level in the cerebrospinal fluid corresponds to the degree of destruction of relevant CNS cells. Therefore, actual direction of the studies of the pathogenesis and diagnosis of CNS diseases is to determine levels of neurospecific markers in the cerebrospinal fluid (CSF). The purpose of the study was to evaluate the diagnostic and prognostic role of NSE, S-100 protein, GFAP and MBP levels in CSF of patients with acute bacterial meningitis. S-100 protein, NSE, GFAP and MBP levels in CSF of patients with acute pneumococcal and meningococcal meningitis were determined during admission and after 10-12 days of treatment. Patients were divided into groups depending on the etiology and severity of the disease. 60 cases of acute bacterial meningitis, as a study group, and 12 cases with acute respiratory infection and meningism, as a control group, were analyzed. It is shown that CSF levels of NSE, S-100 protein, GFAP and MBP on the first day of admission were significantly increased (P<0,05), depending on the severity of the disease. The highest levels of neurospecific markers have been identified in non-survivors (P<0,001). The concentration changes of CSF neurospecific markers are found to be helpful as a diagnostic and prognostic marker in acute bacterial meningitis.Item Chronic hepatitis c: research of topical biochemical aspects in patients(2020) Yurko, K.; Solomennyk, G.; Vinokurova, O.; Verzunova, V.; Hladka, I.80 patients with chronic hepatitis C were examined. Non-invasive evaluation of the necro-inflammatory process of the liver was performed using ActiTest. It is revealed that with high necro-inflammatory activity of the liver, the most likely are changes ofsuch biochemical parameters as f-glutamyltranspeptidase, alanine aminotransferase, haptoglobin, apolipoprotein A1, alpha2-macroglobulin.Item Clinical and epidemiological aspects of yersinioses in kharkiv region(2015) Mohylenets, Olena; Могиленець, Олена Іванівна