The possible role of abnormal uterine bleeding in cardiovascular health during perimenopausal age

Abstract

The manifestation of cardiovascular disease (CVD) in women typically occurs during menopausal transition. Abnormal uterine bleeding (AUB) in perimenopausal women could capture the disaster settings during wartime.Aim – to study the possible pathogenic peculiarities of CVD in perimenopausal women with AUB in a frontline city.Material and methods. The 49 perimenopausal women were enrolled in the study. The 26 women without excessive menstrual loss were included in Group I. The 23 women with AUB were involved in Group II. The variables of body mass index (BMI), menopausal Cooperman’s score and anxiety and stress levels in the study groups were measured. The lipid and carbohydrate metabolism variables, C-reactive protein were detected.Results. The data obtained showed that the variables of BMI, Cooperman’s score, metabolic markers, and CRP were almost similar in the study groups. However, the level of anxiety and stress variables was significantly higher in women with AUB. The variable of BMI demonstrated weak or moderate correlation with HOMA index, blood serum insulin concentration, and CRP. The multivariate logistic regression supported the link between AUB and the Taylor scale score.Conclusion. The increased Spielberger scale score, Taylor scale scores, and perceived stress scale score were found in perimenopausal women with AUB. The logistic regression supported the link between AUB and the anxiety Taylor scale score. The disturbed psychological status could be a valuable addition to anti-aging programs during wartime.