The influence of psychoemotional disorders on the thickness parameters of the intima-media of carotid arteries and tumor necrosis factor-α in young men with arterial hypertension

Abstract

The purpose of the study was to establish the peculiarities of changes in the parameters of the structural state of the common carotid arteries, as well as the content of tumor necrosis factor-α in blood serum depending on psycho-emotional status in young men with arterial hypertension. We examined 76 men (mean age 36.4±3.5 years) with grade 1 hypertension, including 55 patients with moderate and high anxiety (group 1) and no disorders of psychoemotional status (group 2). The control group consisted of 20 healthy men. It was established that in group 1, the levels of systolic and diastolic blood pressure during office measurement and daily monitoring exceeded (p<0.05) the data of group 2. Also, in group 1, the serum levels of tumor necrosis factor-α and the thickness of the intima-media of the carotid arteries were higher (p<0.05) than the indicators of group 2. Thus, in young patients with arterial hypertension, there is an increase in the serum content of tumor necrosis factor-α and signs of structural changes in the carotid arteries, more pronounced in the group with anxiety disorders.