Changes in carbon exchange in patients with post-operative cognitive dysfunction

Abstract

The main blood cells involved in the transport of oxygen and carbon dioxide are erythrocytes [1-4, 8]. Basically, all factors that cause an increase in lactate content, as a rule, lead to an increase in the concentration of pyruvate in the blood, so lactate and pyruvate are recognized at the same time. Lactic acid (lactate) in the body is the end product of glycolysis (anaerobic oxidation of glucose) and glycogenolysis - the processes of glycogen oxidation. Lactate in energy exchange reactions is a metabolic ―dead end‖ because lactate can further be converted into gluconeogenesis reactions. Lactate does not accumulate as a final product and maintains equilibrium with pyruvate. The lactate concentration may depend on the concentration of pyruvate, the intracellular redox state, pH. The effect of the cumulative effect of these factors determines the concentration of lactate, in particular under general anesthesia.