Association between 25-hydroxyvitamin D and metabolic disorders in patients with arterial hypertension and associated comorbidities
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The results of several studies suggest a close relationship between 25-hydroxyvitamin D (25(OH)D) deficiency and the development of metabolic disorders. Given the global increase in the prevalence of cardiometabolic diseases, identifying the role of 25(OH)D as a potential predictor of carbohydrate and lipid metabolism is particularly relevant and warrants further investigation.
Therefore, the present study aimed to assess the relationship between 25-hydroxyvitamin D (25(OH)D) levels and metabolic disorders in patients with arterial hypertension (AH), type 2 diabetes mellitus (T2DM), and obesity (OB). The study included 250 patients, divided into four clinical groups based on the combination of pathologies, as well as a control group. It was demonstrated that patients with comorbid pathology had statistically significantly lower 25(OH)D levels compared to healthy individuals.
Correlation and regression analyses were performed, revealing inverse relationships between serum 25(OH)D levels and markers of insulin resistance, including body mass index (BMI) and glycated haemoglobin (HbA1c). The most pronounced changes were observed in patients with concomitant AH, T2DM, and obesity.
The identified associations confirm the role of vitamin D deficiency in the pathogenesis of metabolic imbalance, insulin resistance, and disturbances of carbohydrate and lipid metabolism. The findings of the study underscore the need to include serum 25(OH)D level assessment in cardiometabolic risk screening programmes for individuals with comorbidities and highlight the potential importance of correcting this deficiency in the management of this patient group.
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Dunaieva I. P. Association between 25-hydroxyvitamin D and metabolic disorders in patients with arterial hypertension and associated comorbidities / I. P. Dunaieva // Bulletin of problems in biology and medicine. – 2025. – Issue 2 (177). – P. 169–175.