Prognostic significance of non-specific systemic inflammation markers in patients with coronary heart disease

Abstract

To evaluate the prognostic significance of markers of nonspecific systemic inflammation as predictors of unfavorable prognosis in patients with coronary heart disease, data from 135 patients with uncomplicated disease and 27 with unfavorable outcomes were analyzed. A 2-year prospective study showed that unfavorable cardiovascular events were significantly more common in patients with coronary heart disease and elevated levels of biomarkers of nonspecific systemic inflammation compared with those with lower values. The presence of myocardial infarction at baseline, a decrease in left ventricular ejection fraction <50 %, and increased levels of markers of nonspecific systemic inflammation such as C-reactive protein, determined by a highly sensitive method, and tumor necrosis factor-α had significant predictive value for the likelihood of unfavorable events.