Features of neurotrophic control and correlation with eosinophils and CD2- receptors of peripheral blood t-lymphocytes in patients with posttraumatic gunshot and non-gunshot injuries of nerves and plexuses of limbs.

Abstract

Introduction: Peripheral nerve injuries are common conditions with a broad spectrum of symptoms depending on the severity and nerves involved. Although a large amount of knowledge about the mechanisms of damage and regeneration has been accumulated, but the number of reliable methods of treatment that ensure full functional recovery is not enough. Materials and Methods: The study included 93 men aged 21 to 59 years with neuropathies and plexopathies, which were divided into 3 groups. All patients underwent neurological, electroneuromyographic, and ultrasound examination. Immunological research was carried out during 12 to 24 months after the onset of the disease. Results: In our study, we found a statistically significant correlation between the content of Beta-NGF and the level of peripheral blood eosinophils (R=0.41, p=0.0191) in patients with post-traumatic gunshot neuropathies and plexopathies. A correlation between the content of Beta-NGF and the CD2+ indicator levels (R=0.56, p=0.00105) in patients with post-traumatic non-gunshot neuropathies and plexopathies was revealed. Conclusion: The analysis of the received research data and literature resources demonstrates an important correlation between the neurotrophins and immunological indicators, which opens up further promising opportunities in the development and use of complex pathogenetic therapy of post-traumatic neuropathies and plexopathies in order to improve the restoration of impaired functions and the quality of life of patients.