Parameters of left ventricular diastolic dysfunction in patients with hypertension disease with concomitant type 2 diabetes mellitus

Abstract

To conduct analyzes of the peculiarities of left ventricular (LV) diastolic function in patients with hypertension disease with concomitant T2DM and without it before and after complex treatment with the inclusion of Eplerenone 50 mg per day and Trimetazidine 80 mg per day.In patients with hypertensive disease of the II stage and hypertensive disease with concomitant type 2 diabetes mellitus, the values of the kinetics of the diastolic movement of the fibrous ring of mitral valve were significantly lower compared to similar indicators of the control group, and these changes were more expressive in comorbid patients. After a three-month course of treatment with Eplerenone and Trimetazidine, the rate of myocardial relaxation in diastole likely increased in both groups of those examined.The prescribed treatment with Eplerenone and Trimetazi dine has led to a decrease in the rate of progression of heart failure and a reduction in cardiovascular risks.