Estimation of mortality prognosis in patients with acute myocardial infarction and type 2 diabetes mellitus taking into account intercellular matrix parameters
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Date
2018
Authors
Котелюх, Марія Юріївна
Кравчун, Павло Григорович
Борзова, Олена Юріївна
Ринчак, Петро Іванович
Журавльова, Марина Ігорівна
Koteliukh, Mariia
Kravchun, Pavlo H.
Borzova, Olena
Rynchak, Petro
Zhuravleva, M.
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Abstract
Ischemic heart disease ranks first among cardiovascular disorders and is one of the
main causes of disability and mortality worldwide. The development and course of acute myocardial
infarction is known to be accompanied by changes in extracellular matrix. Today the impact of
hyperglycemia on intercellular matrix system in patients with acute myocardial infarction and type
2 diabetes still remains disputable.
The study demonstrated a statistically significant increase in matrix metalloproteinase-13 in
an insufficient increase in the level of tissue inhibitor of metalloproteinase-4 in patients with acute
myocardial infarction and type 2 diabetes, indicating an imbalance in intercellular matrix system. The
authors defined prognostic characteristics regarding matrix metalloproteinase-13 and tissue inhibitor
of metalloproteinase-4 in patients with acute myocardial infarction and type 2 diabetes as for
mortality of these patients.
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Keywords
acute myocardial infarction, matrix metalloproteinase-13, extracellular matrix, tissue inhibitor of metalloproteinase-4, type 2 diabetes mellitus
Citation
Estimation of mortality prognosis in patients with acute myocardial infarction and type 2 diabetes mellitus taking into account intercellular matrix parameters / M. Yu. Koteliukh, P. G. Kravchun, O. Yu. Borzova, P. I. Rynchak, M. I. Zhuravleva // Science Review. – 2018. – № 1 (8). – С. 45–50.