Маркери перебігу бронхолегеневої дисплазії при аналізі індукованого мокротиння в періоді ремісії захворювання

Abstract

The 620 samples of induced sputum examination preterm infants aged 1 month to 36 months: 491 examinations of children diagnosed with bronchopulmonary dysplasia (study group) and 129 observations preterm who had respiratory disorders, but did not form bronchopulmonary dysplasia (group). For children with bronchopulmonary dysplasia in remission was characterized by thick-induced sputum (KW H (n = 620) = 37.14, rank - 5.2, p = 0.0001) with a significant number of extracellular bacteria (λUilksa = 0.701; F (4,61) = 65,46; p = 0.0001), white blood cells and alveolar macrophages (λUilksa = 0,767; F (2,67) = 93,49; p = 0.0001). Microbiological markers of BPD were mixt infection opportunistic pathogens and pathogens (KW H (n = 620) = 27.8; rank - 4.49, p = 0.0001). Mixt infection affect the high frequency of bronchial obstruction syndrome (r = 0,382; p <0,05) and severity of bronchopulmonary dysplasia (r = 0,600; p <0,05), and persistence of Pseudomonas aeruginosa, Klebsiella pneumonia correlated with a high mortality rate of bronchopulmonary dysplasia (r = 0,301; p <0,05). These data lead to the need for macro-microscopic and microbiological studies to children in remission for bronchopulmonary dysplasia to identify early markers of acute disease and adverse course of BPD.