Changes in central aortic pressure and arterial stiffness in young men with arterial hypertension and chronic kidney disease

Abstract

The purpose of the study was to investigate changes in central aortic pressure and arterial stiffness in young patients with hypertension and chronic kidney disease and to identify factors influencing these changes. We examined 74 men (mean age 27.3±3.6 years) with hypertension of the 1st and 2nd degree. Depending on the presence of chronic kidney disease, 2 groups were identified: 20 patients without chronic kidney disease (group 1) and 54 patients with chronic kidney disease of stages 1-3 (group 2). The control group included 20 men (mean age 27.1±2.3 years). It was found that in young patients with hypertension, central aortic pressure and pulse wave velocity in elastic arteries are increased compared to the control group; moreover, they are more pronounced in the presence of chronic kidney disease. It was also shown that the daily non-dipper profile and left ventricular hypertrophy were significantly more common in young patients with hypertension and chronic kidney disease compared to the group without renal disease and the control group.