Наукові праці. Кафедра клінічної фармакології та внутрішньої медицини
Permanent URI for this collectionhttps://repo.knmu.edu.ua/handle/123456789/4420
Browse
Recent Submissions
Item Arterial wall condition in women with hypertension and postmenopausal osteoporosis(2023) Kniazkova, Iryna; Bilovol, Alexander; Tsygankov, Alexander; Frolova, Tetyana; Zhadan, Andriy; Bogun, MarynaThe aim of the study was to investigate the indices of arterial stiff ness and central aortic pressure in women with hypertension in combination with osteoporosis. Design and method: The study included 68 females (mean age 62.7±3.8 years) with hypertension, grade 2 in postmenopause including 35 females with osteoporosis (group 1) and 33 females without signs of osteoporosis (group 2) ac cording to osteodensitometry investigation.Item Apelin-13 сoncentration in patients with essential hypertension, extrasystole and obesity.(2023) Kuzminova, Nataliia; Ivankova, Anastasiya; Romanova, Valentyna; Kalitai, Volodymyr; Kulchytska, Olena; Knyazkova, IrynaToday metabolic markers of cardiovascular risk are being actively studied. One of them is apelin-13. Objective: To assess the concentration of apelin-13 in patients with hypertension and extrasystole depending on obesity.Item Вплив похідних 2-окосндолін-3-гліоксилової кислоти на нейрофізіологічні реакції щурів у тесті «чорно-біла камера»(2023) Біловол, О.М.; Луценко, Р.В.; Князькова, І.І. ; Колісник, С.В. ; Шакіна, Е.Г.Уведення сполуки ІК вірогідно подовжувало латентний період першого визирання та виходу й вірогідно зменшувало кількість болюсів порівняно з контролем. 100% тварин визирало в освітлений відсік камери. Похідні 2-оксоіндоліну з лабораторними шифрами 18, Г та ІК змінювали нейрофізіологічні реакції тварин подібно до класичного анксіолітика діазепаму.Item Вплив комбінованої терапії з додаванням еплеренону та триметазидину на діастолічну функцію, вміст SST2 та NT-proBNP у пацієнтів з ГХ та ЦД 2-го типу(2023-09) Біловол, О.М.; Князькова, I.I.; Kірієнко, O.M.; Циганков, О.І.; Абрамова, Л.П.Включення комбінації еплеренону з триметазидином в комплексну терапію хворих на ГХ з ЦД 2 типу протягом 3 місяців сприяло покращенню показників діасто лічної функції, а також позитивно впливало на біомаркер міокардіального стресу і фіброзу – вміст sST2 та дисфункції міокарда – концентрацію NT-proBNP в сироватці крові, поряд з безпечністю і хорошою переносимістю.Item Gender features of the pathogenesis of diabetes mellitus type 2 comorbidity with hypertension(2023-09) Nesen, A.; Kirienko, A.; Semenovykh, P.; Shkapo, V.Nowadays 425 million people suffer from diabetes mellitus (DM). Diabetes mellitus is one of the most common diseases that affect all segments of population. The number of people with diabetes aged 20–79years was predicted to rise to 642 million (uncertainty interval: 521–829 million) by 2040.Item Gender features of the pathogenesis of diabetes mellitus type 2 combined with hypertension(2023) Nesen, A.; Kirienko, A.; Semenovykh, P.; Shkapo, V.; Kirienko, D.; Tovazhnianska, V.The purose of this investigation is to study individual clinical and diagnostic characteristics in patients with type 2 diabetes mellitus with comorbid essential hypertension (DM + HD) with consideration for sex difference. Participants and methods. We examined 41 patients with comorbidity of type 2 diabetes and hypertension (21 men and 20 women) and 30 patients without diabetes, but having a history of hypertension (14 men and 16 women) and 20 healthy individuals. Results. Systolic and diastolic blood pressure (SBP), (DBP) is significantly higher in patients with comorbidity of DM+HD compared with HD (in men, only DBP), while the heart rate did not change. The protein content in urine was below normal values that indicates an early stage of the pathological condition. Women showed a high level of creatinine compared to normal value in both groups, although this indicator is lower compared to men and is statistically significant in DM + HD. In both groups, there were high numbers of left atrium size, end diastolic size (EDS) compared to normal value, while sex differences were noted: EDS was higher in men. The increased size of left atrium directly correlated with the end-diastolic size (higher in men), the thickness of the interventricular septum (TIVS), and thickness of posterior wall (TPW) (with DM + HD, higher in men). In men with DM + HD, the E / A was lower and the thickness of the intima-media complex (IMC) of the right common carotid artery (CCA) was higher than in the HD group. There were no statistically significant differences in the state of right and left common carotid arteries. The ejection fraction was lower compared to normal values. Conclusion. In patients with diabetes mellitus + hypertension and hypertension, the semi-dimorphic differences of TIVS, TPW, E / A, IMC of right CCA can be used to predict the development of pathological process. A decrease in level of protein in urine indicates absence of proteinuria, glomerular filtration disorders, which is due to early stage of formation of DM + HD pathological state in this category of patients. Absence of changes in urea is associated with a sufficient excretory function of kidneys.Item Особливості структурно-функціональних змін в серці і судинах у пацієнтів на цукровий діабет ІІ типу з нефропатією(2023-01) Несен, Андрій; Кірієнко, Олександр; Шкапо, Володимир; Кірієнко, ДенісItem Cardiotrophin-1 as a prognostic biomarker of cardiovascular complications in comorbid patients with hypertension and concomitant type 2 diabetes mellitus and obesity(2023-07) Dunaieva, InnaBackground. Since cardiovascular diseases (CVD) still occupy a leading place in the structure of mortality, the study of biomarkers that can be key in the diagnosis of early signs of the development of cardiovascular pathology continues. One such promising molecule is cardiotrophin-1 (CTF-1). The purpose of this study is to determinate of the circulating level of CTF-1 in comorbid patients with hypertension, and comparative analysis of its serum concentration in the presence of various comorbidities. Materials and methods. 111 patients with hypertension (men/women - 50/61) aged 54.37±1.18 and 20 persons of the control group were examined. In the process of careful examination and supervision of patients, they were divided into 4 groups depending on the presence of comorbid pathology in them: patients with AH- group 1 - 22 people; patients with AH + OB - group 2 - 30 people; AH+T2DM – group 3 – 31 people; patients with AH+T2DM + OB - group 4 - 28 people. Results. A direct correlation of CTF-1 level with weight, BMI, glycated hemoglobin level, SBP and DBP was established (p<0.001). The data we obtained prove that CTF-1 can be a trigger for the occurrence of cardiovascular complications, since its level progressively increases with increasing severity of comorbid pathology, and its highest serum concentration is found in patients with hypertension with concomitant T2DM and obesity. Conclusions. The level of CTF-1 was significantly higher in patients with AH, T2DM, OB compared to patients with AH, patients with AH and OB, as well as with this indicator in the control group. The study of the relationship between the serum level of CTF-1 and metabolic and hormonal indicators in comorbid patients is a promising direction for further research.Item Універсальні можливості лікування кардіоренального синдрому у хворих на цукровий діабет(2023) Кравчун, Павло Павлович; Дунаєва, Інна ПавлівнаЦД 2 типу, який становить більшість усіх випадків ЦД, є серйозною проблемою для охорони здоров’я світової спіль ноти. Очікується, що до 2045 року кількість людей із ЦД зросте із 536,6 до 783,2 млн. Через останні події, пов’язані з пандемією COVID-19, війною в Україні та зміною клімату, які загрожують постачанню продовольства і логістиці, прогнозована ситуація стає ще песимістичнішою. Однак майбутні передбачення вчених щодо збільшення маси тіла населення, ожиріння та випадків ЦД 2 типу є невизначеними.Item Impairment of renal function determined by creatinine and cystatin C levels in patients with hypertension and frequent extrasystoles(2023) Ivankova, A.; Kuzminova, N.; Lozinsky, S.; Knyazkova, I.; Kulchytska, O.; Shkarivsky, Yu.; Romanova, V.156 patients with essential hypertension stage II were examined, among them 124 had frequent extrasystoles, and 32 did not have heart rhythm disorders. Another 30 practically healthy individuals entered the control group. All participants of the study underwent a complete clinical, laboratory, and instrumental examination, including the level of microalbuminuria, electrolytes, creatinine, and cystatin C with the calculation of the glomerular filtration rate. In patients with hypertension, the level of cystatin C was significantly higher compared to the control group (p<0.001). In patients with essential hypertension and extrasystoles, the average level of cystatin C was significantly higher than in patients without extrasystoles (p<0.05). The highest level of cystatin C was noted in patients with hypertension and ventricular extrasystoles. It was significantly higher compared to patients with supraventricular extrasystoles (p<0.05), patients without arrhythmias (p<0.001), and practically healthy subjects (p<0.001). In patients with stage II essential hypertension, the extrasystoles of ventricular origin were associated with an increase in the frequency of microalbuminuria, the highest level of cystatin C, the decrease in the glomerular filtration rate (both creatinine and cystatin), and an increase in the number of patients with a glomerular filtration rate of less than 60 ml/min/1.73 m2. The mean values of the glomerular filtration rate calculated with cystatin C were higher than the corresponding values of the glomerular filtration rate calculated by creatinine.Item Parameters of left ventricular diastolic dysfunction in patients with hypertension disease with concomitant type 2 diabetes mellitus(2023) Bilovol, Olexandr; Knyazkova, Iryna; Dunaieva, Inna; Kiriienko, OlexandrThe aim: To study the parameters of the left ventricular (LV) diastolic function in patients with HT with concomitant T2DM and without it before and after complex treatment with the inclusion of Eplerenone 50 mg per day and Trimetazidine 80 mg per day during 3 months. Materials and methods: The study included 50 patients, aged 45–54 years (mean age 51.3±1.5 years), women – 24 and men 26 with HT stage II. All patients were divided into 2 groups: 1 group (n=25) – patients with HT stage II (HbA1c level of 5.01±0.13%) and 2 group (n=25) – patients with HT stage II and concomitant T2DM (HbA1c level of 7.6±0.34%). The control group consisted of 20 healthy individuals (HbA1c level of 4.68±0.49%). Results: When analyzing the findings on left atrial volume index (LAVI), the highest indicators were observed in patients with HT with T2DM, but slightly lower in HT, and even lower in the control group, but the differences at this stage were not significant. This suggests that functional changes in cardiomyocyte kinetics, which develop in patients with comorbid pathology and are caused by metabolic and hemodynamic disorders, can progress steadily. Conclusions: After a three-month course of treatment with Eplerenone and Trimetazidine, the rate of myocardial relaxation in diastole likely increased in both groups of those examined. The prescribed treatment with Eplerenone and Trimetazidine has led to a decrease in the rate of progression of heart failure and a reduction in cardiovascular risks.Item Dependence of cardiotrophin-1 on biochemical and hormonal factors in patients with comorbid pathology: arterial hypertension, type 2 diabetes mellitus and obesity(ДУ "Інститут проблем ендокринної патології ім. В.Я Данилевського НАМН України", 2023-03) Дунаєва, Інна Павлівна; Біловол, Олександр Миколайович; Dunaieva, I.; Bilovol, O.The prevalence of arterial hypertension, type 2 diabetes mellitus (type 2 DM), and obesity is constantly in-creasing worldwide. Today, a complex of factors, which primarily include chronic emotional stress, pandemics of infectious diseases, military conflicts, have led to a significant increase in chronic noncommunicable diseases. The aim of the study. To determine the dependence of Cardiotrophin-1 on a number of biochemical and hormonal indicators in patients with arterial hypertension, type 2 DM, and obesity, representatives of the Ukrainian population. Materials and methods. The study included 211 patients aged 49 to 65 years, who were divided into groups depending on the pathology: patients with arterial hypertension — 49 persons, Group I; patients with arterial hypertension in combination with class 1 obesity — 54 persons, Group 2; patients with arterial hyper-tension in combination with type 2 DM — 57 persons, Group 3; patients with arterial hypertension, type 2 DM, class 1 obesity — 51 persons, Group 4; as well as 20 persons — the Control group. Determination of the content of Cardiotrophin-1, catestatin, leptin, cystatin C, neutrophil gelatinase-asso-ciated lipocalin (NGAL), Nterminal brain natriuretic peptide (NTproBNP), 25OH vitamin D (Vitamin D3), blood levels was carried out by enzyme immunoassay on Labline90 analyzer (Austria), using commercial test systems manufactured by FineTest (ELISA, China), BT LAB (ELISA, China), DBC (ELISA, China), Elabscience (ELISA, Canada), Monobind Inc. (ELISA, USA).Statistical data analysis was performed, using the statistical software package Statistica, 12 (Stat Soft Inc, USA), Microsoft Office Excel 2013. Data are shown as mean (M) and standard deviations (δ). An error of less than 5 % was considered to be significant (p < 0.05). Stepwise regression analysis was used to determine the ex-tent of exposure of the studied indicators to the CTF-1 level, with its effectiveness assessed by one-way analysis of variance (ANOVA).Results. Thus, the study indicates that comorbid patients with arterial hypertension, type 2 DM, and obesity are predicted to develop complications from the cardiovascular system and Cardiotrophin-1 is a marker of their development. In the examined patients as a whole, the level of Cardiotrophin-1 is closely related to the peptide-hormonal complex: catestatin, leptin, cystatin C, brain natriuretic peptide, and lipocalin associated with neutrophil gelatinase. Conclusions: The serum concentration of Cardiotrophin-1 in patients with arterial hypertension in-creases significantly in a progression with the rate of accession of comorbid pathology and its severity.The Cardiotrophin-1 level in patients with comorbid pathology is affected by catestatin, leptin, cystatin C, NT-pro BNP, as well as the level of triglycerides, HDLC, creatinine, and BMI.Cardiotrophin-1 can be considered as a universal biomarker for the development and progression of cardiovascular disorders in patients with comor-bid pathology of arterial hypertension, type 2 DM, and obesityItem Cardioprotective and metabolic effects of antihypertensive therapy in patients with such comorbidities as arterial hypertension, type 2 diabetes mellitus, and obesity.(2023-05) Дунаєва, Інна Павлівна; Кравчун, Нонна Олександрівна; Ільченко, Ірина Анатоліївна; Dunaieva, I.; Kravchun, N.; Ilchenko, І.Today, high rates of growth of such chronic diseases as hypertension, type 2 diabetes mellitus and obesity are noted in the world. The combination of these pathologies increases the risk of developing fatal cardiovascular complications and cardiac mortality tenfold. A reduction in systolic blood pressure of every 10 mmHg, as shown in the UKPDS study (1998), was associated with a 15% reduction in mortality. The most expedient and justified for now is the appointment for complex treatment of patients with comorbid pathology, antihypertensive drugs that inhibit excessive activation of the ranin-angiotensin-aldosterone system (RAAS), in particular, ACE inhibitors and ARB II. This article highlights the main cardioprotective and metabolic properties of these groups of drugs and the specifics of their appointment, taking into account concomitant pathology.Item Markers of endothelial dysfunction as criteria for destabilization of the disease course in patients with coronary artery disease(2023) Romanova, V.; Kuzminova, N.; Romanova, L.; Lozynskyi, S.; Kniazkova, I.; Kulchytska, O.; Shkarovskyi, Y.To determine the presence and severity of vascular endothelial dysfunction in patients with coronary artery disease and the possibility of diagnosing exacerbation of the atherosclerotic process in such patients by determining markers of endothelial dysfunction, 173 patients with different variants of the disease were examined. It was found that patients with unstable coronary artery disease were characterized by a more pronounced impairment of vascular endothelial function, as evidenced by a significant increase in biochemical markers of endothelial dysfunction (ET-1, sVCAM, and PAPP-A) not only compared to the control group but also to the patients with stable coronary artery disease. Therefore, such markers can be considered criteria for destabilizing the atherosclerotic process. Based on determining the threshold values of endothelial dysfunction in patients with coronary artery disease, groups with definite and possible (“grey zone”) destabilization and without destabilization were identified. Values of ET- 1 ≥10.43 ng/mL, sVCAM ≥1320.0 ng/mL, and PAPP-A ≥10.10 mIU/L were the basis for including patients in the group of patients with a destabilization of the disease even in the absence of clinical manifestations.Item Influence of ethylmethylhydroxypyridine succinate inclusion in antihypertensive therapy on the condition of the arterial wall in young patients with hypertension(2023) Bilovol, O.; Kniazkova, I.; Mishchenko, V.; Kuzminova, N.; Starenkyi, V.; Zhadan, A.; Bogun, M.The purpose of the study was to evaluate the impact of combined antihypertensive therapy including ethylmethylhydroxypyridine succinate on blood pressure levels, arterial stiffness and quality of life in young patients with hypertension. A total of 60 patients (mean age, 41.7±1.3 years) with grade 2 hypertension who were not taking regular antihypertensive therapy were examined. After baseline data collection, 30 patients (group 1) were administered basic therapy with antihypertensive drugs and ethylmethylhydroxypyridine succinate, and 30 patients (group 2) were administered basic therapy, which included a combination of lisinopril 10–20 mg/day and amlodipine 5–10 mg/day for 8 weeks. After the treatment, a decrease in systolic and diastolic blood pressure levels in groups 1 and 2 by 23.3 mm Hg and 17.5 mm Hg and 14.3 mm Hg and 8.4 mm Hg, respectively, was observed (all p<0.05). It was found that average daily levels of systolic and diastolic blood pressure were 7.1 % and 10.8 % (p<0.05) lower in the patients of group 1 compared to group 2 and had a positive effect on daily BP profiles. A more significant decrease in the pulse wave velocity in the aorta was observed (2.1±0.5 m/s, p<0.05) in group 1, while in group 2 this parameter decreased by (1.5±0.5 m/s, p<0.05). There was an improvement in the scale scores representing physical health, working capacity, psychological abilities, degree of severity of negative psychological state, as well as the ability to social contacts more expressed in group 1. Therefore, inclusion of ethylmethylhydroxypyridine succinate in the therapeutic complex in young patients with hypertension increases efficacy of antihypertensive therapy, improves daily blood pressure profiles and positively affects the quality of life in this category of patients.Item Differences in cystatin C level depending on parameters of daily blood pressure monitoring in patients with essential hypertension and frequent extrasystoles(2023-01) Kuzminova, N.; Ivankova, A.; Lozinsky, S.; Knyazkova, I.; Ivanov, V.; Kulchytska, O.; Shkarivsky, Yu.156 patients with stage II essential hypertension were examined, among them, 124 had frequentsymptomatic extrasystole and 32 patients did not have any heart rhythm disorders. Another 30 healthy persons were included in the control group. Complete clinical, laboratory and instrumental examinations were applied to all study participants, including daily blood pressure monitoring and cystatin C serum concentration. It was found that the level of cystatin C was significantly higher in hypertensive patients compared to controls (р<0.001). In turn, in the presence of extrasystoles, the mean cystatin C was significantly higher than in patients without extrasystoles (p<0.05). The highest level of cystatin C was noticed in patients with essential hypertension and ventricular extrasystole. It was significantly different from the patients with extrasystole of supraventricular origin (p<0.05) and patients without arrhythmias (p<0.001) or healthy individuals (p<0.001). Also, higher values of blood pressure and a relatively high level ofserum cystatin C were found in patients with hypertension, which allows us to suspect the common pathophysiological mechanisms of an increase in the cystatin C level, values of blood pressure and the occurrence of frequent extrasystoles (especially of the ventricular origin).Item Dynamics of SST2 and NT-PROBNP in patients with arterial hypertension and type 2 diabetes mellitus based on combined therapy with eplerenone and trimetazidine addition(2023) Bilovol, O.; Kniazkova, I.; Kirienko, O.; Kuzminova, N.; Sushetska, A.; Starenkiy, V.; Abramova, L.The purpose of our study was to investigate the effect of complex therapy with the addition of eplerenone and trimetazidine on the state of left ventricular diastolic function, as well as levels of soluble growth-stimulatingreceptor expressed by gene 2 and N-terminal fragment of brain natriuretic propeptide in patients with arterial hypertension with type 2 diabetes mellitus. After registration baseline data were recorded, 42 patients (group 1) were prescribed baseline therapy and 38 patients (group 2) were prescribed eplerenone 25-50 mg once daily and trimetazidine 80 mg once daily in addition to antihypertensive therapy for 3 months. The control group consisted of 20 practically healthy individuals. After the treatment, a significant decrease in the level of soluble growth-stimulatingreceptor expressed by gene 2 in the blood of patients in both groups was found, but in group 2 this indicator did not differ from the control group, while in group 1 it remained significantly higher than in healthy individuals. At the same time, the level of N-terminal fragment of brain natriuretic propeptide significantly decreased by 1.3 times and 1.6 times in groups 1 and 2, respectively, but remained significantly higher than in the control group. A significant decrease E/e`mean was determined in both groups of patients, but in group 2 by 8.9 % less than in group 2 and a decrease in the geometric parameters of the left atrium, more pronounced in group 2. Thus, the addition of eplerenone and trimetazidine to the complex therapy of patients with arterial hypertension and type 2 diabetes mellitus during 3 months improved diastolic function, and also had a positive effect on the biomarker of myocardial stress and fibrosis soluble growth-stimulatingreceptor expressed by gene 2 level and myocardial dysfunction N-terminal fragment of brain natriuretic propeptide concentration in serumItem Parameters of left ventricular diastolic dysfunction in patients with hypertension disease with concomitant type 2 diabetes mellitus(2023-12) Dunaieva, Inna; Bilovol, OlexandrTo conduct analyzes of the peculiarities of left ventricular (LV) diastolic function in patients with hypertension disease with concomitant T2DM and without it before and after complex treatment with the inclusion of Eplerenone 50 mg per day and Trimetazidine 80 mg per day.In patients with hypertensive disease of the II stage and hypertensive disease with concomitant type 2 diabetes mellitus, the values of the kinetics of the diastolic movement of the fibrous ring of mitral valve were significantly lower compared to similar indicators of the control group, and these changes were more expressive in comorbid patients. After a three-month course of treatment with Eplerenone and Trimetazidine, the rate of myocardial relaxation in diastole likely increased in both groups of those examined.The prescribed treatment with Eplerenone and Trimetazi dine has led to a decrease in the rate of progression of heart failure and a reduction in cardiovascular risks.Item Effect of anti-hypertensive therapy on arterial wall stiffness in patients with arterial hypertension(2023) Bilovol, O.; Kniazkova, I.; Mishchenko, V.; Zhadan, A.; Kuzminova, N.; Starenky, A.; Bogun, M.The purpose of the study was to conduct a comparative analysis of the effect of 3-month therapy with a fixed combination of lisinopril dihydrate and amlodipine besylate on the clinical status, indicators of the daily profile of blood pressure, central aortic pressure and vascular stiffness, as well as the structural and functional state of the heart in patients with arterial hypertension with obesity and without it. 60 patients (average age 56.7±2.1 years) with stage 2 arterial hypertension were examined, 34 of which were diagnosed with Class 1 obesity (group 1) and 26 patients (group 2) without obesity who did not take regular antihypertensive therapy. After registration of baseline data, a fixed combination of lisinopril dihydrate and amlodipine besylate 10–20/5–10 mg/day was prescribed to the patients of both groups for 3 months. The control group consisted of 20 practically healthy people. After therapy, a significant improvement was found not only in the office systolic and diastolic blood pressure levels, but also in the daily profile of peripheral blood pressure and central blood pressure in both groups of patients. It was also established that the pulse wave propagation speed decreased by (1.0±0.2 m/s; p<0.01) in group 1 and by (1.5±0.2 m/s; p<0.01) in group 2. A significant decrease in the left ventricular myocardial mass index was found in both groups of patients. An increase in the E/A ratio was established by 33.3 % (p<0.001) in group 1 and by 26.3 % (p<0.01) in the patients of group 2. Thus, the long-term use of a fixed combination of lisinopril dihydrate and amlodipine besylate in arterial hypertension patients with obesity and without it, allows to control blood pressure effectively according to office measurement and daily blood pressure monitoring, has a positive effect on daily blood pressure profiles and indicators of arterial stiffness, as well as structural and functional parameters and status of diastolic function of the left ventricle, along with good tolerability of therapy.Item Role of cystatin C in the diagnosis and prognosis of the development of cardiorenal syndrome in comorbid patients with arterial hypertension(2023-07) Dunaieva, InnaThe purpose of our study was to determine of diagnostic and prognostic role of cystatin C in the development of cardiorenal syndrome in the case of arterial hypertension syndrome and maximum comorbid conditions. 111 patients and 20 persons of the control group were examined. In the current examination process, they were divided into 4 groups depending on the presence of comorbid pathology in them: patients with arterial hypertension – 1 group – 22 people; patientswith arterial hypertension in combination with obesity – group 2 – 30 people; arterial hypertension in combination with type 2 diabetes – group 3 – 31 people; patients with hypertension, type 2 diabetes and obesity – group 4 – 28 people. The level of cystatin C in the examined cases with arterial hypertension and various comorbidities was significantly higher compared to individuals of the control group. Significant effect of the cardiotrophin-1 residue on cystatin C. An increased level of cystatin C is associated with an increase in blood pressure, the level of cardiotrophin-1, catestatin, which ensures its role in the early development of nervous and cardiovascular complications in patients with arterial hypertension with various hormonal comorbidities and confirms the significance of the activity of adipose tissue in the development of kidney dysfunction.