A Study of the Effect of Specific Antibacterial Therapy on the Course of Tuberculous Spondylitis in an Experiment

Abstract

Objective — to assess the impact of modern antibacterial therapy on the development of a specific destructive process in experimental tuberculous spondylitis in animals. Based on the histological examination of the vertebral bodies, it was established that the animals treated with specific first-line ABD showed clear morphological features of tuberculous inflammation. In animals treated with specific second-line ABD, inhibition of the pathological process. This study showed that the implementation of modern intensive specific antibacterial therapy in experimental conditions allows to achieve the delimitation of the destructive process in the relatively early stages of the disease development (4—5 weeks). The obtained new knowledge about the pathomorphological features of the course of TS against the background of carrying out specific antibacterial therapy allows radical surgical interventions on the musculoskeletal system without the risk of generalization of the tuberculosis process at an earlier time (compared with the generally accepted ones).