Please use this identifier to cite or link to this item:
http://repo.knmu.edu.ua/handle/123456789/3302
Title: | Metabolic abnormalities in colorectal cancer patients |
Authors: | Zhukov, Viktor Vinnik, Yuriy Perepadya, S. Moiseenko, A. Gramatiuk, S. |
Keywords: | HOMA-IR lipid metabolism colorectal cancer patients cancer |
Issue Date: | Jan-2013 |
Citation: | Metabolic abnormalities in colorectal cancer patients / V. I. Zhukov, Y. A. Vinnik, S. V. Perepadya, A. S. Moiseenko, S. N. Gramatyuk // American Journal of Nursing Science. – 2013. – Vol. 2 (2). – P. 18–20. |
Abstract: | Normally, cells grow, divide and produce more cells as they are needed to keep the body healthy and functioning properly. Cancer cell growth is different from normal cell growth. Instead of dying, cancer cells continue to grow and form new, abnormal cells. Aim of the research. The aim of the study was to estimate of the association between the anthropometric obesity, fasting serum concentration of glucose, glycosylated hemoglobin, insulin, total cholesterol, HDL/LDL fractions, triglycerides, a homeostasis model of assessment (HOMA-IR) colorectal cancer patients. Colon cancer was diagnosed in 239 patients aged from 35 to 76 years. For each patient, the following data were considered: anthropometric measurements (weight, height, waist circumference values), fasting serum concentration of glucose, glycosylated hemoglobin, insulin, total cholesterol, HDL/LDL fractions, triglycerides. Also, three index: BMI (Body Mass Index; kg/m2) HOMA-IR (Homeostasis Model of Assessment - Insulin Resistance; fasting glucose (mmol/L) x fasting insulin (mU/L)/22.5). The average fasting serum concentration of glucose, glycosylated hemoglobin, insulin, total cholesterol, HDL/LDL fractions, triglycerides and HOMA-IR index were statistically significantly higher in patients transverse colon cancer (P < 0.001). Triglycerides increased with the appropriate forms of CRC by 58.8%, 47%, 52.9% and 64.7%. Studies have shown a violation of the protein and lipid metabolism in patients with colon carcinogenesis, which should be assumed to prevail over anabolic processes. |
URI: | https://repo.knmu.edu.ua/handle/123456789/3302 |
Appears in Collections: | Наукові праці. Кафедра біологічної хімії |
Files in This Item:
File | Description | Size | Format | |
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10.11648.j.ajns.20130202.12.pdf | 155,04 kB | Adobe PDF | View/Open |
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