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http://repo.knmu.edu.ua/handle/123456789/26908
Title: | Impact of percutaneous coronary intervention on markers of matrix degradation and endothelial-dependent mediators in patients with acute myocardial infarction and diabetes mellitus type 2 |
Authors: | Minukhina, Diana Zaikina, Tetiana Koteliukh, Mariia Tytova, Ganna Zolotaikina, Viktoriia |
Keywords: | matrix degradation endothelial-dependent mediators acute myocardial infarction diabetes mellitus type 2 percutaneous coronary intervention (PCI) |
Issue Date: | Feb-2020 |
Citation: | Impact of percutaneous coronary intervention on markers of matrix degradation and endothelial-dependent mediators in patients with acute myocardial infarction and diabetes mellitus type 2 / D. Minukhina, T. Zaikina, M. Koteliukh [et al.] // Georgian medical news. – 2020. – N 2 (299). – Р. 70–74. |
Abstract: | Aim of study ‒ assess an impact of percutaneous coronary intervention on markers of matrix degradation (MMP-13, TIMP-4) and endothelial-dependent mediators (sVE-cadherin, ADMA) in patients with acute myocardial infarction and diabe- tes mellitus type 2. 110 patients with AMI were enrolled in the study, 70 patients had concomitant diabetes mellitus type 2. They were addition- ally divided into two subgroups depending on the treatment (percutaneous coronary intervention or conservative therapy). According to the obtained results, misbalance of extracellular matrix degradation markers (MMP-13, TIMP-4) and endothelial dysfunction (sVE-cadherin, ADMA) were revealed in patients with acute myocardial infarction. Performing of PCI procedure contributes to the significant lowering of MMP-13, sVE-cad- herin, ADMA and increasing of TIMP-4 in diabetic patients. It was establishted that performing of percutaneous coro- nary intervention in patients with acute myocardial infarction and diabetes mellitus type 2 contributes to the maintenance of extracellular matrix that prevents myocardium remodeling and improvement of endothelial function. |
URI: | https://repo.knmu.edu.ua/handle/123456789/26908 |
Appears in Collections: | Наукові праці. Кафедра внутрішньої медицини № 2 і клінічної імунології та алергології ім. ак. Л.Т. Малої |
Files in This Item:
File | Description | Size | Format | |
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70-74 (1).pdf | 1,15 MB | Adobe PDF | View/Open |
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