The influence of phosphorus complex organic mixtures on the content of sexual hormones and gonadotropins in the serum with violations in the reproductive system
Date
2017-12
Authors
Zharova, A.
Bagmut, I.
Titkova, A.
Marakushyn, Dmytro
Rezunenko, Yu.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
At 100 Wistar rat population in subacute experiment the effect of small doses of subtoxical phosphorus detergents (Efasol, Polifos, Syntaf) on the level of sex hormones in the blood serum of females - estrogen and gonadotropins was investigated by radioimmunoassay. There were 9 research groups and one control, 10 animals in each (N=100). Estrogen and gonadotropins were studied in rat serum. Significant inhibition of gonadotropin secretion may be combined with the permeability of the haemato-encefalic barrier for phosphorus complex organic compounds and their direct influence on the hypothalamic-pituitary neuroendocrine complex.
Description
Thus, complex organic phosphorus compounds - Efasol, Polifos-72, Syntaf 10- 18 at doses of 1/10 and 1/100 LD50 at long subtoxical action can inhibit the synthesis and secretion of gonadotropins (FSH, LH, PL) and hormones (ED, PG). Under such circumstances the genital dysfunction, disorders of the formation of secondary sexual characteristics, violation of ovarian-menstrual cycle and lactation should be expected.
The Journal of Medicine and Philosophy 1311
Thus, in terms of working environment and a significant burden on the body of phosphorus compounds the formation of dysfunction in sexual instinct and mental status in women may be expected.
The analysis shows that a significant inhibition of gonadotropin secretion may be combined with the permeability of the haemato-encephalic barrier for phosphorus complex organic compounds and their direct impact on the hypothalamic-pituitary neuroendocrine complex
Keywords
xenobiotics, progesterone, prolactin, luteotropin, follicle-stimulating hormone, rats
Citation
The influence of phosphorus complex organic mixtures on the content of sexual hormones and gonadotropins in the serum with violations in the reproductive system / A. I. Zharova, I. Yu. Bagmut, A. V. Titkova, D. I. Marakushyn, Yu. K. Rezunenko // The Journal of Medicine and Philosophy. – 2017. – Issue 6 (2), (December), volume 42. – P. 1306–1310.