An impact of oligoesters of polyatomic alcohol on the content of cytochromes in microsomal fraction of rats’ liver

Abstract

Study of mechanisms of pathological processes development is actual one in modern science. Impact of xenobiotics on organism is also important and actual study in modern science. Defined ways of organism adaptation to xenobiotics action were formed during evolution, central role in which presents biochemical mechanisms of their decontamination. Samples of OEF-LP 502 (polyoxypropylene glycol) and 503 (polyoxypropylene triol) were used in this work with defined physical and chemical peculiarities. Experiments were done on sexually mature rats of Wistar with body weight (180-220) gram. Long-lasting impact of OEF-LP 502 and 503 in doses 1/10 and 1/100 LD50 is characterized by destruction of functional condition of rats’ liver microsomes that is defined by decrease of cytochrome Р450 and b5 content. Increase of cytochrome level on the 15th day of substances impact is adaptive reaction of organism to xenobiotics intake, which is connected with decontamination process, but on the other hand with generation of active forms of oxygen and products of lipid peroxidation.