Publication:
Monitoring fetal maturation - Objectives, techniques and indices of autonomic function

dc.contributor.authorHoyer, Dirk
dc.contributor.authorŻebrowski, Jan
dc.contributor.authorCysarz, Dirk
dc.contributor.authorGoncalves, Hernani
dc.contributor.authorPytlik, Adelina
dc.contributor.authorAmorim Costa, Célia
dc.contributor.authorBernardes, Joao
dc.contributor.authorAyres-de-Campos, Diogo
dc.contributor.authorWitte, Otto
dc.contributor.authorSchleußner, Ekkehard
dc.contributor.authorStroux, Lisa
dc.contributor.authorRedman, Christopher
dc.contributor.authorGeorgieva, Antoniya
dc.contributor.authorPayne, Stephen
dc.contributor.authorClifford, Gari
dc.contributor.authorSignorini, Maria
dc.contributor.authorMagenes, Giovanni
dc.contributor.authorAndreotti, Fernando
dc.contributor.authorMalberg, Hagen
dc.contributor.authorZaunseder, Sebastian
dc.contributor.authorLakhno, Igor
dc.contributor.authorSchneider, Uwe
dc.date.accessioned2023-04-21T15:43:53Z
dc.date.available2023-04-21T15:43:53Z
dc.date.issued2017-04-18
dc.description.abstractMonitoring the fetal behavior does not only have implications for acute care but also for identifying developmental disturbances that burden the entire later life. The concept, of "fetal programming", also known as "developmental origins of adult disease hypothesis", e.g. applies for cardiovascular, metabolic, hyperkinetic, cognitive disorders. Since the autonomic nervous system is involved in all of those systems, cardiac autonomic control may provide relevant functional diagnostic and prognostic information. The fetal heart rate patterns (HRP) are one of the few functional signals in the prenatal period that relate to autonomic control and, therefore, is predestinated for its evaluation. The development of sensitive markers of fetal maturation and its disturbances requires the consideration of physiological fundamentals, recording technology and HRP parameters of autonomic control. Based on the ESGCO2016 special session on monitoring the fetal maturation we herein report the most recent results on: (i) functional fetal autonomic brain age score (fABAS), Recurrence Quantitative Analysis and Binary Symbolic Dynamics of complex HRP resolve specific maturation periods, (ii) magnetocardiography (MCG) based fABAS was validated for cardiotocography (CTG), (iii) 30 min recordings are sufficient for obtaining episodes of high variability, important for intrauterine growth restriction (IUGR) detection in handheld Doppler, (iv) novel parameters from PRSA to identify Intra IUGR fetuses, (v) Electrocardiographic (ECG) recordings allowed a stable heart beat detection in the maturation periods between 20 to 28 weeks of gestation only, (vi) correlation between maternal and fetal HRV is disturbed in pre-eclampsia. The reported novel developments significantly extend the possibilities for the established CTG methodology. Novel HRP indices improve the accuracy of assessment due to their more appropriate consideration of complex autonomic processes across the recording technologies (CTG, handheld Doppler, MCG, ECG). The ultimate objective is their dissemination into routine practice and studies of fetal developmental disturbances with implications for programming of adult diseases.en_US
dc.identifier.citationMonitoring fetal maturation-objectives, techniques and indices of autonomic function / D. Hoyer, J. Zebrowski, D. Cysarz, H. Goncalves, A. Pytlik, C. Amorim-Costa, J. Bernardes, D. Ayres-de-Campos, O. W. Witte, E. Schleußner, L. Stroux, C. Redman, A. Georgieva, S. Payne, G. Clifford, M. G. Signorini, G. Magenes, F. Andreotti, H. Malberg, S. Zaunseder, I. Lakhno, U. Schneider // Physiol Meas. – 2017. – Vol. 38, No 5. – P. 61–88. – DOI 10.1088/1361-6579/aa5fca.en_US
dc.identifier.otherDOI 10.1088/1361-6579/aa5fca
dc.identifier.urihttps://repo.knmu.edu.ua/handle/123456789/31923
dc.language.isoenen_US
dc.publisherIOP Scienceen_US
dc.subjectfetal developmenten_US
dc.subjectautonomic nervous systemen_US
dc.subjectheart rate variabilityen_US
dc.subjectnonlinear signal analysisen_US
dc.subjectfunctional autonomic brain age scoreen_US
dc.subjectfABASen_US
dc.subjectCTGen_US
dc.subjectMCGen_US
dc.subjectECGen_US
dc.subjectprenatal diagnosisen_US
dc.titleMonitoring fetal maturation - Objectives, techniques and indices of autonomic functionen_US
dc.typeArticleen_US
dspace.entity.typePublication
relation.isAuthorOfPublication515b1fe6-d88e-4687-8de8-707e4fca1a75
relation.isAuthorOfPublication.latestForDiscovery515b1fe6-d88e-4687-8de8-707e4fca1a75

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
nihms902709.pdf
Size:
1.36 MB
Format:
Adobe Portable Document Format
Description:

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
11.22 KB
Format:
Item-specific license agreed upon to submission
Description: