Кафедра радіології та радіаційної медицини
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Item Clinical significance of ultrasonography in evaluation of morphofunctional state of liver and portohepatolienal bloodstream in chronic diffuse liver diseases(2015-06) Fedulenkova, YuliiaAbstract: In randomized three-phase prospective cohort controlled research which included 2564 persons with chronic diffuse liver diseases (1865 cases of fatty liver disease, 462 cases of chronic hepatitis, 100 cases of liver cirrhosis) and 137 healthy controls, the clinical significance of ultrasonography in quantitative evaluation of liver parenchyma morphofunctional state and portohepatolienal bloodstream in patients with chronic diffuse liver diseases was estimated. Twenty-seven ultrasound and two additional, derived from laboratory tests index parameters were testified for the grounding to be included into diagnosis-prognostic algorithm for patients with this pathology, which has been developed, validated and recommended for practical application. Further perspectives are related to fundamental logico-statistical analysis of the data for development of mathematic model of pathologic process and its application to practical health care service.Item Clinico – pathogenetic reasoning of echography and computed tomography role in diagnosis of chronic diffuse liver disease(2015-06) Fedulenkova, YuliiaAbstract: In three-stage prospective cohort controlled research of 2876 persons with chronic diffuse liver diseases (2076 cases of fatty liver disease, 509 cases of chronic hepatitis, 139 cases of liver cirrhosis) and 152 healthy controls the clinical significance of radiation methods of investigation in quantitative evaluation of liver morphofunctional state in patients with chronic diffuse liver diseases was estimated. Diagnosis-prognostic algorithm for patients with this pathology was developed, validated and recommended for practical application. Further perspectives are related to detailed chronic diffuse liver diseases stratification by intensity of steatosis (in fatty liver disease), activity (in chronic hepatitis), fibrosis (in chronic hepatitis and liver cirrhosis).Item Dental radiology(ХНМУ, 2018) Пилипенко, Микола Іванович; Pilipenko, MykolaItem Diagnostic Radiology(KhNMU, Grigoriev's Institute of Medical Radiology, 2008) Pilipenko, Mykola Ivanovich; Vikman, Yan Eduardovich; Slabodchikov, Mykola Egorovich; Gorleku, Filip; Dedjoe, ViktorChapters from the textbook devoted to modern consepts of radiologic imagingItem Experimental evaluation of accurasy in determining the direction to a pulsed sourse of gamma-radiation by a spherical absorber with CdTe detectors in a system of nuclear situation monitoring(Східно-Європейський журнал передових технологій, 2020) Cherniavskiy, I.; Starenky, Vyktor Petrovych; Tiutiunyk, V.; Rolin, I.; Sheptur, O.; Kurtseitov, T.; Tverezovskyi, M.; Salii, O.; Pidhorodetskyi, M.The necessity and possibility of creating a dosimetric channel for determining the direction to the source of penetrating gamma-radiation in the nuclear situation monitoring system have been substantiated. The experimental assessment of a reduced error of the device for determining the direction to pulsed sources of radiation using a spherical absorber and CdTe detectors was carried out. These detectors can be used effectively only if there is appropriate electronic equipment, constructed in accordance with their characteristics and spectral-temporal characteristics of highly intense pulsed radiation. The direction to high-intensity pulsed radiation of linear accelerator Varian Clinac 600C (USA) by telluride-cadmium detectors was determined in the pulsed mode. This allowed conducting an experiment to determine the dependence of the coefficient of proportionality of recording pulses from each detector on the angle of direction to the source of pulsed radiation of the linear accelerator. A reduced error was assessed by comparing the received experimental data with a theoretical dependence based on a physical and mathematical model. It was recommended to divide the entire range of angles from 0° to 360° into five sub-ranges, in which three or two proportionality coefficients are responsible for determining the angle in space on gamma sources. The maximum reduced error does not exceed 10 % and the maximum angle error is not more than 8.4°. The most accurate determining of the angle to a radiation source can be carried out in the presence of a theoretically calculated and experimental database of proportionality coefficients for all angles in space and energy of radiation sourcesItem Radiation Medicine(2013) Pilipenko, Mykola IvanovichItem Item Item Retrospective analysis of the course of thyroid carcinoma with lung metastases after radioiodine therapy(Periódico Tchê Química, 2020) Astapieva, Olha; Fedulenkova, Yuliia; Grushka, Ganna; Paskevych, Olha; Maksimishyn, OleksiiMetastasis of malignant tumors are one of the most acute problems of oncology. Among the organs and systems of the human body in terms of frequency of damage, one of the first places is occupied by the lungs, which is probably closely related to the anatomical features of their structure and physiology. During the first examination of cancer patients, metastases in the lungs are revealed in 6-15%, lymphogenous metastases are observed in 50-81%. With differentiated thyroid carcinoma (thyroid gland), metastases in the lung are most often detected (up to 15% of cases). At the same time, 5- and 10-year survival rates are 50-92.6% and 42-86%, respectively. The use of 131I-sodium iodide is central to the treatment of these patients. The purpose of the paper is to study the effectiveness of radioiodine therapy for metastases of thyroid carcinoma in the lung. We used clinical, laboratory, radiological methods for the diagnosis of thyroid carcinoma and pulmonary metastases. From 1986 to 2010, 68 patients from the clinic of the S.P. Hryhoriev Institute of Medical Radiology of the Academy of Medical Sciences of Ukraine were included in the study. Lung metastases were found in patients with all stages of the disease and with diverse sizes of the primary thyroid tumor. After the surgical treatment of patients, 131Isodium iodide was used in various doses of radioactivity. The full therapeutic effect of radiotherapy was achieved in 5 patients (7.8%) over a 3-year period of treatment, and a 5-year period – in 28 (43.8%); stabilization or partial effect was noted in 24 patients (37.8%), disease progression was observed in 12 patients (17.6%). Mortality from disease progression was 12.5%.Item Some Questions of Methodology for condacting tests of radiation protection of armored objects(Национальный научный центр Харьковский физико-технический институт, 2020) Dovbnya, A.; Starenky, Vyktor Petrovych; Goncharov, I.; Cherniavskiy, I.; Anashkin, O.; Vlasenko, V.; Ovcharenko, K.The results of approbation of the methodology for laboratory testing a materials for armored objects‘ radiation protection by determining their half-value layer for nuclear radiations, which are typical for the main situations of the radiation factor effect in modern conditions, are presentedItem Study of the role of digital radiological examination in the diagnosis of lung changes in Coronavirus disease(2021) Spuziak, Roman; Ulko, Roman; Maksimishyn, Oleksii; Stepanov, Ernst; Спузяк, Роман Михайлович; Улько, Роман Володимирович; Максімішин, Олексій Володимирович; Степанов, Ернст ПавловичWorld Health Organization announced that COVID-19 was a “public health emergency”. Тhe number of patients with COVID-19 and deaths from this disease are increasing every day, so the issue of diagnosis and treatment of this serious pathology remains relevant.Item USE IR-Spectroscopy in treatment oncology patient with bone metastases by 153 Smoxabifor(Национальный научный центр Харьковский физико-технический институт, 2020) Grushka, Ganna; Dikiy, N.; Krasnoselskiy, Nikolai; Bereznyak, E.; Medvedeva, E.Using infrared spectroscopy, we studied the character of intermolecular interactions in the samples blood plasma of oncological patients with bone metastases in the treatment of their modern β-emitter 153Sm-oxabifor. The therapeutic dose of the 153Sm-oxabifor was 1.0 mCi/kg of the patient's body weight. Analysis of the IR-spectra showed that already after the rst course of palliative radionuclide therapy there is a tendency to balance the products of free radical nature and antioxidants, which indicates the e ectiveness of the treatment. Molecular changes in the blood plasma of cancer patients with bone metastases registered using infrared spectroscopy are speci c during palliative therapy.Item The Use of Fullerene C60 to Preserve Testicular Tissue after Cryopreservation(Journal of Nanomaterials, 2021-04) Volkova, Nataliia; Yukhta, Mariia; Goltsev, Anatoliy; Юхта, Марія СергіївнаAutologous transplantation of cryopreserved fragments of an immature testis is an actively developing approach to save fertility in patients facing a gonadotoxic therapy. The use of bioavailable fullerene C60 as a powerful antioxidant opens up a new potential for the prevention and correction of ischemic-reperfusion pathological processes in tissues including those associated with freezing-thawing procedure. In this work, we aimed to study the antioxidant status, apoptotic/necrotic processes, and morphological characteristics of cryopreserved fragments of the seminiferous tubules of testis (CrFSTT) of immature rats after incubation in media with different concentrations of fullerene C60 (10, 15, and 20 μg/mL). Our results indicated that the addition of C60 in a concentration of 15 μg/mL decreased ROS production, cytochrom C release, and degree of histological damage of spermatogenic epithelium as well as increased the activity of the mitochondria, antioxidant defense system, and cell density in histological sections of CrFSTT compared to the control. Fullerene C60 at investigated concentrations did not impact significantly on apoptosis in cells of CrFSTT but, after incubation with 15 μg/mL C60, a percentage of living cells was 1.2-fold higher and a value of necrotic ones in this group was 1.6-fold lower than the control samples (). Relative amount of cells of the spermatogonia germ layer did not differ between the studied concentrations. The general analysis of obtained data showed that the C60 addition in the concentration of 15 μg/mL was the most optimal for the rehabilitation of CrFSTT. The results can be used for the development of an effective rehabilitation medium for the cryopreserved testicular tissue.Item Vitrification of rat testicular tissue using biopolymers(Institute for Problems of Cryobiology and Cryomedicine, 2020) Volkova, N.; Yukhta, Maryia; Goltsev, A.Item Аномальні зображення грудної клітки(ХНМУ, 2019) Пилипенко, Микола ІвановичItem Аномалії дихальних шляхів(ХНМУ, 2019) Пилипенко, Микола ІвановичItem Аномалії зображення грудної клітки(ХНМУ, 2019) Пилипенко, Микола ІвановичItem Багаторічний досвід лікування раку щитоподібної залози в ДУ «інститут медичної рідіології ім. С. П. Григор’єва НАМН України»(Інститут медичної рідіології ім. С.П. Григор’єва НАМН України, 2015-06-16) Ткаченко, Григорій Іванович; Васильєв, Леонід Якович; Астап’єва, Ольга Миколаївна; Грушка, Ганна Василівна; Луховицька, Наталля Ігорівна; Савченко, Антонына Степанівна; Ріяко, В.М.Зростання рівня захворюваності на рак щитоподібної залози (РЩЗ), що простежується останнім часом, призвело до виникнення великої низки соціально-економічних та медичних проявів в Україні. В онкопатологічній статистиці ця хвороба виділена в самостійну статистичну одиницю. Рак щитоподібної залози складає приблизно 1–22 % від усіх злоякісних новоутворів. Онкопатологія цієї локалізації є причиною смертності 1% хворих, які помирають щороку від злоякісних пухлин.Item Базові настанови до субспеціальності рентгенологія(2019-12-11) Пилипенко, Микола Іванович