Кафедра нейрохірургії
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Item Arteriovenous malformations clinical experience(Euripean Association of Neurosurgical Societies, 2012-10-25) Piatykop, Vladimir; Kotlyarevskiy, Yuriy; Sergienko, Yulia; Pshenichniy, Anton; Naboychenko, AndreyItem Cerebrovascular diseases(2019) Pyatikop, VolodymirThe presentation covers etyology, pathology, clinic and management of cerebrovascular diseases.Item Computed tomography dataset analysis for stereotaxic neurosurgery navigation(2019) Avrunin, Oleg; Tymkovych, Maksym; Semenets, Valerii; Piatykop, VolodimirItem Crryodestruction or radioablation ofadenohypophysis Inin treatmentofofpainin cancercer patients(2015) Tsygankov, Alexander; Msallam, Mohammad; Drubot, Alla; Al-Trawneh, MohamadItem CT-stereotactic biopsy of deep localized brain neoplasms(Euripean Association of Neurosurgical Societies, 2012-10-25) Piatykop, Vladimir; Kutoviy, Igor; Naboychenko, AndreyItem Efficacy potential of combined treatment of metastatic brain tumors(2015) Al-Trawneh, Mohamad; Pyatikop, Vladimir; Tsygankov, Alexander; Kutoviy, Igor; Derimedvid, Lyudmyla; Trubacheva, ElenaItem Functional neurosurgery, low back pain(2020) Pyatikop, VolodymirThe presentation covers fuctional neurosurgery and low back pain syndrome.Item History of neurosurgery, anatomy and phisiology of nervous system, investigation methods(2020) Pyatikop, VolodymirCrash course in history of neurosurgery, neuroanatomy and investigations.Item Morphological characteristics of metastatic brain tumors and their primary sources(2016) Pyatikop, Vladimir; Al-Trawneh, Mohamad; Pliten, OksanaEvaluation of morphological differences between primary tumors and their intracerebral metastases was performed in operational specimens from 41 patients with intracerebral metastases (carcinoma in 80,5±6,19 %, melanoma in 19,5±6,19 %) and primary tumors: skin melanoma (8 cases), lungs carcinoma (17 cases), breast carcinoma (16 cases). Standard basic micromorphological processing was performed. The structure of intracerebral metastatic melanoma foci had similarities with primary foci, but with higher atypicity, vascularity, surrounding by "muffs" of tumor cells, hemorrhagic, inflammatory and necrotic foci. Tumor tissue of lungs-derived metastatic focus repeated the structure of primary tumor, in patches glandular formations go with solid layers of acinar structures in the center, stroma in these places is not prominent giving an evidence of de-differentiation. In primary breast tumors and their brain metastases morphology was almost identical. It was proved that brain metastatic tumor tissue is characterized by lower differentiation comparing with primary tumorItem Neuroinduced mesenchymal stem cells efficiency for reconstruction of rat sciatic nerve defects(2021) Piatykop, V.; Zavgorodnia, N.; Kaliuzhka, V.; Shchegelskaya, E.; Geletka, O.; Markevych, M.Peripheral nerves damage is a frequent pathology with significant socio–economic significance. The aim of research was to study regeneration potential of transplanted biodegradable fibrin matrices filled with neuroinduced mesenchymal stem cells for peripheral nerves damage in rats and evaluate degree of anatomical and functional integrity. The study was carried out on 48 mongrel female rats aged 3–4 months (250±50 g) which were divided into 4 groups. Sciatic nerves of all rats were intersected with formation of 10 mm gap and then reconstituted using autografts, acellular fibrin matrix and fibrin matrix with neuroinduced mesenchymal stem cells. Functional, electrophysiological tests and histological evaluation were performed to analyze functional and anatomical recovery during 2 months after injury. It has been shown that using neuroinduced mesenchymal stem cells for restoration of large size gap and recovery of function of peripheral nerve after its damage is effective method according to functional, electrophysiological, histological results.Item Neurooncology(2019) Pyatikop, Volodymir; Stognii, ArtemPresentation covers primary and secondary brain tumor pathology and its management.Item Neurosurgery Study Guide(AUS Medicine Publishing, 2021-07-01) Pyatikop, Volodymyr; П'ятикоп, Володимир; Piatykop, Iryna; Sergiienko, Yuliia; Zavgorodnya, Nataliia; Kaliuzhka, Vladyslav; П'ятикоп, Ірина; Сергієнко, Юлія; Завгородня, Наталія; Калюжка, ВладиславThe study guide is compiled in accordance with the curriculum in neurosurgery. The basics of diagnosis and treatment of patients with the most common neurological diseases of the brain and spinal cord, spine and its structures, peripheral nerves are highlighted. The publication uses modern European and American protocols for the management of such patients. Each section contains a list of recommended reading. For students of higher medical education establishment, interns.Item Oncology of the nervous system(2019) П'ятикоп, Володимир Олександрович; Pyatikop, VolodymirTopic of this presentation is neurooncology.Item Preoperative endovascular management for hypervascularised intracranial tumors(Euripean Association of Neurosurgical Societies, 2012-10-25) Piatykop, Vladimir; Kotlyarevskiy, Yuriy; Kutoviy, Igor; Sergienko, Yulia; Pshenichniy, Anton; Naboychenko, AndreyItem Structural and biological evaluation of new chitosan membrane for dural closure(2019) П'ятикоп, Володимир Олександрович; Кравцова, Анна Віталіївна; Калінкевич, Оксана В.; Калінкевич, Алексей Н.; Pyatikop, Volodymyr; Kravtsova, Anna; Kalinkevich, Oksana; Kalinkevich, AlekseiObjective: to study the structural and biological evaluation of chitin-chitosan based membrane for dura mater replacement. Materials and methods. Chitosan-based films were made out of 3% solution of chitosan for the research. We used 200, 500 and 700 kDa chitosan (deacetylation rate 80–90 %) to produce chitin-chitosan membrane by using solvent evaporation method. For enhancing mechanical properties and reducing the degradation, chitin particles were added to the chitosan solution. Chitosan and chitin ratio was 80/20. The chitin/chitosan solution in Petri dishes was dried out during 3 days at room temperature. To obtain information about the structure of membrane surface and crosssection scanning, electron microscopy was performed. Hydrolytic degradation was studied by pouring into SBF solution. To determine the rate of enzymatic degradation, trypsin solution was used. To determine the mass loss percentage, we measured the sample weight after 7, 14, 21, 30 and 60 days after being in the appropriate solutions. Relative elongation and strength were measured by digital dynamometer to study membranes mechanical properties such as the strength and elasticity. MLO-A5 cells were used to assess biocompatibility of new materials. Results. Macroscopic view of obtained samples has shown their relative transparency with impregnation of chitin particle that elevated over the membrane surface without any diversity between different chitosan molecular weight samples. Due to scanning electron microscopy, principal diversity between the samples of different molecular weight has being seen: rough pore surface at 200 and 500 kDa and flat with minimal roughness surface of 700 kDa membranes. Cross-section of 500 and 700 kDa membranes are dense with no pores, but 200 kDa membrane are sponge like and it can be prediction for fluid sorption and cell migration during healing process. Chitin-chitosan membranes are biocompatible and degrade in aqueous and enzymatic solutions. Due to polysaccharide nature of chitosan and chitin, enzymatic degradation has shown higher trend compare to the hydrolytic ones. 200 kDa membrane degrades faster with final mass loss 83.2 % and completely due to porous structure that allows fluid sorption. Membrane mechanical parameters strongly depend on their structure. 200 kDa membrane has shown 2-fold higher elongation compared to 500 kDa and 3-fold — compared to 700 kDa ones. The compensation of mechanical forces ensured by porous structure is better than in dense ones. Tensile strength was in 2-fold better in 200 kDa membranes than in 500 and 700 kDa ones. Cell culture experiment has shown the better adhesion at the 3rd day for 200 kDa membrane and minimal cell adhesion for 700 kDa membrane, probably due to smooth surface. The reduction rate between all samples and PCT control differ a lot, except for 200 kDa membrane that has the same proliferation rate as TCP. Conclusion. Chitin-chitosan membranes, made from different molecular weight chitosan, are transparent and has appropriate structure for being used as a dura mater substitute. They are biocompatible and degrade in aqueous and enzymatic solutions. Due to porous structure, excellent mechanical properties as well as better cell adhesion and proliferation, 200 kDa chitosan membrane is more applicable for neurosurgical issues.Item Study of functional disorders of the brain stem in patients with tumors of the posterior cranial fossa and their importance in an operational treatment(2013) Sypitiy, Vitaliy; Pyatikop, Vladimir; Chmut, Viktor; Kutsin, Vladislav; Genkin, A.Цель работы - улучшение результатов лечения, профилактику осложнений у больных с опухолями задней черепной ямки за счет применением микрохирургической техники, малоинвазивного доступа