Наукові праці. Кафедра неврології
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Browsing Наукові праці. Кафедра неврології by Subject "cognitive impairment"
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Item New markers for diagnosis and prognosis of cognitive impairment in patient with multiple sclerosis(Kharkiv National Medical UniversityTeslenko O. New markers for diagnosis and prognosis of cognitive impairment in patient with multiple sclerosis / O. Teslenko, O. Tovazhnyanska // Inter Collegas. ─ 2022. ─ Vol. 9, No.1. ─ Р. 14─18., 2022-09-30) Teslenko, Oleksandra; Tovazhnyanska, OlenaThe article presents modern approaches to the diagnosis of brain damage and development of cognitive impairment in patients with multiple sclerosis. Neurodegenerative changes, which take place in the early stages of the disease and play an important role in the formation of irreversible neurological deficits, are considered. Cognitive impairment in patients with multiple sclerosis is quite common, but they are not always noticed, but they significantly reduce patients' quality of life. The article describes the possibilities of neuroimaging methods to identify structural changes in the parts of the brain responsible for cognitive functions. The importance of brain neurotrophic factor (BDNF) as a promising biomarker of multiple sclerosis is presented. Further study of BDNF remains interesting, which will allow to develop algorithms for early diagnosis and pre-diction of disease progression, that will provide an opportunity to deepen the understanding of the place of BDNF in the pathomorphological chain of nervous system damage in multiple sclerosisItem New-onset isolated acalculia as a consequence of right temporo-parieto-occipital junction infarct(2022-09) Nekrasova, Nataliya; Tovazhnyanska, Olena; Singh, Rhea; Rudenko, Serhii; Riznichenko, Olena; Zub, KseniiaAcalculia is defined as a form of cognitive impairment, manifested by the loss of ability to perform calculating operations and use arithmetical concepts because of the damage to some parts of the cerebral cortex, with a subcortical extension. Case presentation. We present a unique case of a 74-year-old right-handed patient with isolated acalculia on a background of ischemic stroke in the right parietal lobe. Physical examination, laboratory tests, and various instrumental and neurological investigations including electroencephalogram and magnetic resonance imaging (MRI) were performed. Brain MRI showed a subacute infarct in the area of the right temporo-parieto-occipital junction and multiple subcortical lesions of vascular origin in the frontal and parietal lobes. The patient was treated with aspirin, enalapril, and atorvastatin, along with cognitive rehabilitation therapy. During subsequent follow-up visits, a decrease in the severity of acalculia was noticed, but complete recovery was yet to be achieved.