Кафедра внутрішніх та професійних хвороб
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Browsing Кафедра внутрішніх та професійних хвороб by Subject "left ventricular geometry"
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Item BODE index in patients with chronic obstructive pulmonary disease in combination with hypertensive heart disease(2020-12) Kapustnik, Valeriy; Kostyuk, Inna; Melenevych, Anastasiia; Tverezovskyi, VolodymyrThe prognostic potential of the BODE index in assessing future cardiovascular risk in patients with chronic obstructive pulmonary disease in combination with hypertensive heart disease based on left ventricular geometry has been established. Comparing the BODE index results depending on the type of left ventricular remodeling, a significant (p=0.032) increase in the index was determined in patients with prognostically unfavorable left ventricular remodeling compared to relatively favorable types – 1.73±0.45 scores vs. 1.45±0.63 scores. Patients with comorbid conditions showed a significant decrease in exercise tolerance and a tendency to desaturation. In order to increase the BODE index sensitivity in predicting the course of chronic obstructive pulmonary disease of the GOLD 2 grade, group B in combination with stage II hypertension, we propose to consider the presence of desaturation. That is, to consider a decrease in the saturation levels during a six-minute walk test from the initial value ≥4% as one of the prognostically unfavorable criteria.Item Gender differences in exercise capacity and left ventricular geometry among patients with comorbid pathology – hypertension with chronic obstructive pulmonary disease(2023-09) Melenevych, AnastasiiaHypertension (HT) and chronic obstructive pulmonary disease (COPD) are one of the most common comorbid pathologies associated with the risk of cardiovascular events. As long as the ejection fraction (EF) remains preserved, it is quite challenging to establish signs of heart failure. Dyspnea and exercise intolerance in COPD can mask reduced heart function, especially in hypertensive patients. Our aim was to assess gender differences in exercise capacity using 6-min walk test (6MWT) and left ventricular (LV) geometry among patients with HT and COPD. We found that dyspnea level before and after the 6MWT, drop in SpO2 during the 6MWT as well as the distance walked in the 6MWT showed no significant (p > 0,05) gender differences. LV systolic function was preserved in all patients (EF > 55 %). LV diastolic function echocardiographic parameters didn’t show significant differences between men and women. At the same time, we found that all women had unfavorable types of LV geometry (concentric and eccentric hypertrophy), concentric hypertrophy was predominated. All four types of LV geometry were found among men. Thus, despite the lack of differences in clinical and functional data by gender, the predominance of LV concentric hypertrophy in women was reliably established among the patients with HT and COPD.Item Interleukin-18/interleukin-10 ratio in predicting the further course of chronic obstructive pulmonary disease combined with hypertension(General medicine, 2019) Kapustnik, Valeriy; Kostyuk, Inna; Melenevych, AnastasiiaThe article presents the results of analysis of main prognostically significant criteria depending on the values of interleukin-18/interleukin-10 (IL-18/IL-10) ratio in patients with chronic obstructive pulmonary disease (COPD) combined with hypertension (HT). Growth of IL-18/IL-10 ratio was associated with emphysematous changes in chest X-ray, increase in the degree of dyspnea, decreased exercise tolerance, increased levels of desaturation, lower body mass index, waist and mid-arm circumferences. The results of echocardiography revealed that all patients with comorbid pathology had signs of myocardial overload. Patients of the first tertile (IL-18/IL-10 < 23) had more pronounced signs of an overload of the left heart. Instead, patients of the third tertile (IL-18/IL-10 ≥ 59) had more pronounced signs of an overload of the right heart by pressure. Prognostically unfavorable types of left ventricular geometry (concentric hypertrophy and eccentric hypertrophy) were more common in patients of the first tertile.