Кафедра пропедевтики педіатрії № 2
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Browsing Кафедра пропедевтики педіатрії № 2 by Subject "cystic fibrosis"
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Item Cystic fibrosis social aspects in Ukraine(National Health as Determinant of Sustainable Development of Society. Editors: Nadiya DUBROVINA & Stanislav FILIP. Monograph. School of Economics and Management in Public Administration in Bratislava, 2021) Klymenko, Viktoriia; Piontkovska, Oksana; Pasichnyk, Olena; Drobova, NadiiaCystic fibrosis (CF) is a genetically determined pathology. It belongs to the orphan diseases group. CF is an important social problem not only in Ukraine but also all over the world. The main social problems of CF patients in Ukraine are insufficient and late diagnosis of the disease, lack of genetic passport of most patients, severe disease course with psychological problems in the family, lack of access to high-tech treatment algorithms (gene therapy, lung transplantation), short life expectancy and difficult financial position. In recent years, there have been the number of positive changes in the treatment and management of CF patients in Ukraine. Implementation of international standards of treatment and care is the only way to improve the life quality of CF patients.Item Features of Cystic Fibrosis Course in Children Depending on Interleukin-4 Gene Mutation(2018) Drobova, NadiiaCystic fibrosis (CF) course features depend not only on the difference in CF transmembrane conductance regulator gene mutations, but also onother gene modifiers. Interleukin-4 (IL-4) gene is a one of gene modifiers. The aim of the present study was to improve medical care for patients with CF by clarifying the pathogenic role of IL-4 gene polymorphism in the course of the disease. The study involved examination of 42 children with CF and 54 practically healthy children as control group. Patient examination was carried out by the standard methods in the remission period. Determination of C589T polymorphism of IL-4 gene was carried out using polymerase chain reaction inreal time. DNA was isolated from buccal epithelium cells. Patients with IL-4 gene mutation (C589T) were characterized by more frequent primary manifestation of the respiratory signs, Staphylococcus aureus predominance within respiratory pathological microorganisms, the incidences of bronchiectasis and lung fibrosis, more severe liver lesions, elevated total serum immunoglobulin E level, elevated levels of the CD25 lymphocytes, circulating immune complex and reduced immunoglobulin A levels. The data demonstrate features of CF phenotype associated with IL-4 gene polymorphism.