Features of Cystic Fibrosis Course in Children Depending on Interleukin-4 Gene Mutation
Date
2018
Authors
Drobova, Nadiia
Journal Title
Journal ISSN
Volume Title
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Abstract
Cystic fibrosis (CF) course features depend not only on the difference in CF
transmembrane conductance regulator gene mutations, but also onother gene modifiers.
Interleukin-4 (IL-4) gene is a one of gene modifiers. The aim of the present study was to
improve medical care for patients with CF by clarifying the pathogenic role of IL-4 gene
polymorphism in the course of the disease. The study involved examination of 42 children
with CF and 54 practically healthy children as control group. Patient examination was carried
out by the standard methods in the remission period. Determination of C589T polymorphism
of IL-4 gene was carried out using polymerase chain reaction inreal time. DNA was isolated
from buccal epithelium cells. Patients with IL-4 gene mutation (C589T) were characterized
by more frequent primary manifestation of the respiratory signs, Staphylococcus aureus
predominance within respiratory pathological microorganisms, the incidences of
bronchiectasis and lung fibrosis, more severe liver lesions, elevated total serum immunoglobulin
E level, elevated levels of the CD25 lymphocytes, circulating immune complex and reduced
immunoglobulin A levels. The data demonstrate features of CF phenotype associated with
IL-4 gene polymorphism.
Description
Keywords
interleukin-4 gene mutation, children, cystic fibrosis, clinical and paraclinical features
Citation
Drobova N. M. Features of Cystic Fibrosis Course in Children Depending on Interleukin-4 Gene Mutation / N. M. Drobova // Inter Collegas. – 2018. – Vol. 5, N 2. – С. 73–79.