Browsing by Author "Bodnia, I."

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Clinical predictors of Вlastocystosis treatment efficacy
(Georgian Association of Business Press, 2024-04) Bodnia, I.; Bodnia, K.; Maslova, V.; Ogienko, V.; Pavliy, V.
Improvement of methods and criteria for diagnostics of human blastocystosis and selection of drugs for etiotropic therapy remain urgent scientific tasks of the present day. Clinical manifestations of blastocystosis in humans are diverse, and in this regard, their influential role on the effectiveness of blastocystosis therapy cannot be excluded. Materials and methods: To assess the predictor properties of clinical symptoms, we retrospectively analyzed them in 300 patients with blastocystosis in alternative groups: group A − with good therapeutic effect (n = 162) and group B − with satisfactory effect (n = 138). Group A included patients who had an overall regression rate of clinical symptoms ≥ 33% after 1 month from the start of treatment and ≤ 32% in group B. Results and discussions: Preliminary analysis showed that reliable differences between the groups were established for most clinical symptoms, which provided the basis for the development of a prognostic algorithm using a heterogeneous sequential Wald-Henkin procedure [19]. It was found that high prognostic informativity was shown by liver enlargement (J= 3,38), the presence of heaviness in the right subcostal area (J = 2,45), tachycardia (J = 1,76), decreased efficiency (J = 1,63), the degree of manifestation of clinical symptoms in general (J = 1,74), the nature of body temperature (J = 1,56), the presence of dizziness (J = 1,46) and duration of the disease (J = 1,07). Moderate predictive properties were characterized for the patient's age (J = 0,67) and the presence of vegeto-visceral dysfunction (J = 0,96), joint pain (J = 0,87), headache (J = 0,67), heart pain (J = 0,64), and muscle pain (J = 0,53). Low prognostic informativeness was established with regard to the presence of seizures (J = 0,42), lymphoadenopathy (J = 0,33) and spleen enlargement (J = 0,30). No predictor value was found for symptoms such as abdominal pain syndrome (J = 0,09), memory impairment (J = 0,008), skin manifestations (J = 0,04), jaundice (J = 0,02), and patient gender (J = 0,01). The testing of the predictive algorithm on the training group (n=300) established its high efficiency, as the erroneous predictions amounted to 3% and did not exceed the specified (5%; p < 0.05) level of reliability. Correct predictions amounted to 77% and uncertain predictions amounted to 20% of cases. Conclusions: Using the heterogeneous sequential Wald Genkin procedure, an algorithm was created to predict the effectiveness of therapy for patients with blastocystosis, which determined the values of the prognostic coefficients of each gradation of indicators and their general prognostic information content. The highest prognostic informativeness was found for clinical symptoms such as liver enlargement (J = 3,38), right subcostal heaviness (J = 2,45), tachycardia (J = 1,76), degree of manifestation of clinical symptoms (J = 1,74) and body temperature (J = 1,56). Testing the algorithm at 95% reliability level on the training group (n=300) revealed its high efficiency, as the erroneous predictions amounted to 3% and did not exceed the specified (5%; p < 0,05) reliability level. Correct predictions amounted to 77% and uncertain predictions amounted to 20% of cases.
Distribution and frequency of Blastocystis sp. by methods of microscopy and cultivation in faeces of residents of Kharkov region
(2022-07) Bodnia, I.; Pokhil, S.; Bodnia, K.; Pavliy, V.; Skoryk, L.
Psychological features of rehabilitation of HIV-infected patients
(Georgian Association of Business Press, 2024) Lantukh, I.; Kucheriavchenko, V.; Yurko, K.; Bondarenko, A.; Merkulova, N.; Mohylenets, O.; Gradil, G.; Bondar, O.; Bodnia, I.; Burma, Ya.; Tsyko, O.; Tkachenko, V.
The human immunodeficiency virus (HIV) is one of the major medical problems in the world. For almost forty years, it has had catastrophic effects on the body of infected people with variable pathogenesis of mortality. The purpose of the work is to analyse the importance of psychological assistance for the social adaptation of HIV-infected patients. Materials and methods: The empirical basis of the study was the analysis of 30 medical records of inpatients. The majority were patients of working age, namely 25 people (83.3%), while the average age of the patients was (28.5±5.5) years old. During the study, patients were divided into groups depending on the receipt of psychological help, psychoemotional disorders, and signs of social maladjustment. Results: The first group of patients consisted of 10 (33.3%) patients who refused psychological help. The second group, namely 20 (66.7%) patients, consisted of patients who received psychological help immediately after the diagnosis of HIV infection and had milder disorders. During the research, a set of methods was used: clinical and anamnestic method; to assess the presence of depression in patients, the Montgomery-Asberg Depression Rating Scale (MADRS) was used; the Spielberger-Khanin anxiety questionnaire was used to determine the level of anxiety in patients; patients' adherence to treatment was determined using the Morisky-Goin compliance assessment scale. Conclusions: The issue of adaptation of HIV-infected patients in society is a significant problem caused by the low level of awareness of HIV infection and the ways of its transmission. The obtained results indicate the need for psychological assistance to HIV-infected persons at every stage, both at the time of the announcement of the diagnosis (prevention of the development of depression, suicidal intentions), and during drug treatment (debriefing of the methodology, creation of peer-to-peer support groups), thanks to which the social adaptation of patients and the effectiveness of medical treatment are accelerated.
Relation of the immunologic status of blastocystosis patients with the effectiveness of their therapy
(WHO Office in Azerbaijan, 2024-05) Bodnia, I.; Yurko, K.; Bodnia, K.
To study the presence of a relationship between the state of immunologic homeostasis and the effectiveness of blastocystosis therapy, the values of immunity indices were compared in 300 patients with blastocystosis in alternative groups: group A − with good therapeutic effect (n = 162) and group B − with satisfactory effect (n = 138). Group A included patients who had an overall clinical symptom regression rate of ≥33% after 1 month of treatment, and group B included patients who had an overall regression rate of ≤32%. When comparing the correlation structures of immunity indices in the groups, it was found that they differ significantly (by 90%) in their “portrait” properties (nature of correlation). In patients with a good therapeutic effect in comparison with the alternative group is characterized by a more pronounced antibodyalogenesis of all classes of antibodies (Ig M, Ig A, Ig G and IgE), which indicates their leading role in the formation of protective reactions in patients with blastocystosis. The established significant (90%) differences in the nature of relationships in the groups indicate that in patients depending on the effectiveness of their therapy, fundamentally different pathogenetic matrices of immune homeostasis are formed, which substantiates the possibility of using immune indicators as predictors.